Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1980 Jul;18(1):27–36. doi: 10.1128/aac.18.1.27

Inhibition of clinically significant bacterial organisms in vitro by 2-acetylpyridine thiosemicarbazones.

A S Dobek, D L Klayman, E T Dickson Jr, J P Scovill, E C Tramont
PMCID: PMC283934  PMID: 7416748

Abstract

Antibacterial activity of 65 2-acetylpyridine thiosemicarbazones and related compounds was determined by using clinical isolates of nine bacterial genera. Minimal inhibitory concentrations (MICs) of 0.002 to 0.062 micrograms/ml were obtained with 23% of the compounds for Neisseria gonorrhoeae and 0.016 to 0.062 micrograms/ml with 17% of the compounds for N. meningitidis. Staphylococcus aureus was inhibited in the MIC range of 0.125 to 0.5 micrograms/ml by 18% of the thiosemicarbazones, whereas 26% inhibited group D enterococcus with an MIC of 0.25 to 2.0 micrograms/ml. Poor antibacterial activity was shown toward the gram-negative bacilli, i.e., Pseudomonas, Klebsiella-Enterobacter, Shigella, Escherichia coli, and Proteus.

Full text

PDF
31

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. FORMAL S. B., LABREC E. H., KENT T. H., FALKOW S. ABORTIVE INTESTINAL INFECTION WITH AN ESCHERICHIA COLI-SHIGELLA FLEXNERI HYBRID STRAIN. J Bacteriol. 1965 May;89:1374–1382. doi: 10.1128/jb.89.5.1374-1382.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. GERHARDT P., HEDEN C. G. Concentrated culture of gonococci in clear liquid medium. Proc Soc Exp Biol Med. 1960 Oct;105:49–51. doi: 10.3181/00379727-105-26005. [DOI] [PubMed] [Google Scholar]
  3. Klayman D. L., Bartosevich J. F., Griffin T. S., Mason C. J., Scovill J. P. 2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents. J Med Chem. 1979 Jul;22(7):855–862. doi: 10.1021/jm00193a020. [DOI] [PubMed] [Google Scholar]
  4. Klaymann D. L., Scovill J. P., Bartosevich J. F., Mason C. J. 2-Acetylpyridine thiosemicarbazones. 2. N4,N4-Disubstituted derivatives as potential antimalarial agents. J Med Chem. 1979 Nov;22(11):1367–1373. doi: 10.1021/jm00197a017. [DOI] [PubMed] [Google Scholar]
  5. LIDWELL O. M. Apparatus for phagetyping of Staphylococcus aureus. Mon Bull Minist Health Public Health Lab Serv. 1959 Mar;18:49–52. [PubMed] [Google Scholar]
  6. Protivinsky R. Chemotherapeutics with tuberculostatic action. Antibiot Chemother (1971) 1971;17:101–121. doi: 10.1159/000392367. [DOI] [PubMed] [Google Scholar]
  7. Rees R. J. Leprosy. A preliminary review of the experimental evaluation of drugs for the treatment of leprosy. Trans R Soc Trop Med Hyg. 1967;61(4):581–595. doi: 10.1016/0035-9203(67)90111-3. [DOI] [PubMed] [Google Scholar]
  8. WHITE L. A., KELLOGG D. S., Jr NEISSERIA GONORRHOEAE IDENTIFICATION IN DIRECT SMEARS BY A FLUORESCENT ANTIBODY-COUNTERSTAIN METHOD. Appl Microbiol. 1965 Mar;13:171–174. doi: 10.1128/am.13.2.171-174.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Wagner W. H., Winkelmann E. Untersuchungen über die tuberkulostatische Wirksamkeit neuartiger Benzaldehyd- und Thiophenaldehyd-Thiosemicarbazone in vitro and in vivo. Arzneimittelforschung. 1972 Oct;22(10):1713–1716. [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES