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. 1980 Jul;18(1):125–129. doi: 10.1128/aac.18.1.125

Inhibition of dengue virus replication by amantadine hydrochloride.

W C Koff, J L Elm Jr, S B Halstead
PMCID: PMC283951  PMID: 7416739

Abstract

The effect of amantadine hydrochloride (1-adamantanamine hydrochloride) on dengue virus replication was examined in vitro. Amantadine decreased the titers of all four types of dengue viruses grown in LLC-MK2 cells by greater than 90% at concentrations of 50 micrograms/ml. There was no evidence for any cytopathic effect of the drug at concentrations less than 100 micrograms/ml. Studies of the time of addition showed that the antiviral effect was maximal when drug was added to virus cultures immediately after the viral adsorption period. In addition, amantadine caused a marked reduction in the growth of dengue virus type 2 in both human and rhesus peripheral blood leukocytes without affecting cell viabili ty. These findings demonstrate that amantadine significantly inhibits the replication of dengue viruses in vitro and indicate a need to determine the efficacy of this drug against dengue virus infections in vivo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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