Abstract
Acrylate monomers with pendant biguanide groups were successfully synthesized, and their homopolymers and copolymers were prepared with acrylamide. These cationic disinfectants of polymeric forms exhibited high antibacterial activity against gram-positive bacteria, whereas they were less active against gram-negative bacteria. It was found that the activity of the polymeric disinfectants was much higher than that of the monomeric species, and the difference in activity between the polymers and the monomers was discussed on the basis of their contributions to each elementary process of the lethal action.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bernard E., Faucon J. F., Dufourcq J. Phase separation induced by melittin in negatively-charged phospholipid bilayers as detected by fluorescence polarization and differential scanning calorimetry. Biochim Biophys Acta. 1982 May 21;688(1):152–162. doi: 10.1016/0005-2736(82)90590-9. [DOI] [PubMed] [Google Scholar]
- Costerton J. W., Cheng K. J. The role of the bacterial cell envelope in antibiotic resistance. J Antimicrob Chemother. 1975 Dec;1(4):363–377. doi: 10.1093/jac/1.4.363. [DOI] [PubMed] [Google Scholar]
- Davies A., Bentley M., Field B. S. Comparison of the action of vantocil, cetrimide and chlorhexidine on Escherichia coli and its spheroplasts and the protoplasts of gram positive bacteria. J Appl Bacteriol. 1968 Dec;31(4):448–461. doi: 10.1111/j.1365-2672.1968.tb00394.x. [DOI] [PubMed] [Google Scholar]
- El Mashak E. M., Tocanne J. F. Polymyxin B-phosphatidylglycerol interactions. A monolayer (pi, delta V) study. Biochim Biophys Acta. 1980 Feb 28;596(2):165–179. doi: 10.1016/0005-2736(80)90351-x. [DOI] [PubMed] [Google Scholar]
- Ikeda T., Ledwith A., Bamford C. H., Hann R. A. Interaction of a polymeric biguanide biocide with phospholipid membranes. Biochim Biophys Acta. 1984 Jan 11;769(1):57–66. doi: 10.1016/0005-2736(84)90009-9. [DOI] [PubMed] [Google Scholar]
- Ikeda T., Tazuke S., Watanabe M. Interaction of biologically active molecules with phospholipid membranes. I. Fluorescence depolarization studies on the effect of polymeric biocide bearing biguanide groups in the main chain. Biochim Biophys Acta. 1983 Nov 23;735(3):380–386. doi: 10.1016/0005-2736(83)90152-9. [DOI] [PubMed] [Google Scholar]
- Sixl F., Galla H. J. Polymyxin interaction with negatively charged lipid bilayer membranes and the competitive effect of Ca2+. Biochim Biophys Acta. 1981 May 20;643(3):626–635. doi: 10.1016/0005-2736(81)90358-8. [DOI] [PubMed] [Google Scholar]