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. 1984 Aug;26(2):272–274. doi: 10.1128/aac.26.2.272

Imipenem antagonism of the in vitro activity of piperacillin against Pseudomonas aeruginosa.

M A Bertram, L S Young
PMCID: PMC284137  PMID: 6435517

Abstract

The MICs of imipenem and piperacillin, alone and in combination, against Pseudomonas aeruginosa were determined in a checkerboard titration microdilution assay. A dramatic, one-way antagonism of imipenem for piperacillin was demonstrated in 28 of the 35 strains examined; antagonism was associated with the induction of a beta-lactamase.

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Selected References

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