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. 1992 Nov;36(11):2569–2572. doi: 10.1128/aac.36.11.2569

Molecular basis of the efficacy of cefaclor against Haemophilus influenzae.

M Picard 1, F Malouin 1
PMCID: PMC284379  PMID: 1489208

Abstract

Cefaclor sustained its inhibitory activity against a beta-lactamase-producing strain of Haemophilus influenzae. Although a relatively high permeability coefficient was calculated for ampicillin compared with that calculated for cefaclor, the resulting periplasmic concentration of cefaclor was 5.7 times that of ampicillin. The efficacy of cefaclor may be due to its higher beta-lactamase resistance, which allows it to achieve a greater periplasmic concentration and adequate binding to crucial penicillin-binding proteins.

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Selected References

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