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. 1994 Mar;38(3):534–541. doi: 10.1128/aac.38.3.534

In vitro activities of two glycylcyclines against gram-positive bacteria.

G M Eliopoulos 1, C B Wennersten 1, G Cole 1, R C Moellering 1
PMCID: PMC284494  PMID: 8203851

Abstract

The glycylcyclines designated CL 329,998 and CL 331,002 are N,N-dimethylglycylamido derivatives of minocycline and 6-demethyl-6-deoxytetracycline, respectively. In vitro activities of these two antimicrobial agents were compared with those of tetracycline, minocycline, and seven other antimicrobial agents against 412 gram-positive organisms. Both new drugs were significantly more active than minocycline against methicillin-resistant Staphylococcus aureus (MICs for 90% of isolates tested, 0.25 and 0.5 microgram/ml versus 4 micrograms/ml). CL 329,998 inhibited all streptococci, lactobacilli, and Leuconostoc spp. at concentrations of < or = 0.5 microgram/ml, with CL 331,002 slightly less active against some species. All enterococci, including minocycline-resistant and multidrug-resistant isolates, were inhibited at < or = 0.5- and < or = 1.0-microgram/ml concentrations of the new drugs, respectively. Only bacteriostatic activity was evident by time-kill curves. The two glycylcyclines demonstrated activities in vitro that were superior to those of minocycline against several gram-positive bacterial species, and at relatively low concentrations, they inhibited isolates resistant to both tetracycline and minocycline.

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Selected References

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  1. Chopra I., Hawkey P. M., Hinton M. Tetracyclines, molecular and clinical aspects. J Antimicrob Chemother. 1992 Mar;29(3):245–277. doi: 10.1093/jac/29.3.245. [DOI] [PubMed] [Google Scholar]
  2. Collins L. A., Malanoski G. J., Eliopoulos G. M., Wennersten C. B., Ferraro M. J., Moellering R. C., Jr In vitro activity of RP59500, an injectable streptogramin antibiotic, against vancomycin-resistant gram-positive organisms. Antimicrob Agents Chemother. 1993 Mar;37(3):598–601. doi: 10.1128/aac.37.3.598. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Eliopoulos G. M., Gardella A., Moellering R. C., Jr In-vitro activity of Sch 29482 in comparison with other oral antibiotics. J Antimicrob Chemother. 1982 Feb;9 (Suppl 100):143–152. doi: 10.1093/jac/9.suppl_c.143. [DOI] [PubMed] [Google Scholar]
  4. Eliopoulos G. M. Increasing problems in the therapy of enterococcal infections. Eur J Clin Microbiol Infect Dis. 1993 Jun;12(6):409–412. doi: 10.1007/BF01967433. [DOI] [PubMed] [Google Scholar]
  5. Geslin P., Buu-Hoi A., Frémaux A., Acar J. F. Antimicrobial resistance in Streptococcus pneumoniae: an epidemiological survey in France, 1970-1990. Clin Infect Dis. 1992 Jul;15(1):95–98. doi: 10.1093/clinids/15.1.95. [DOI] [PubMed] [Google Scholar]
  6. Lyon B. R., Skurray R. Antimicrobial resistance of Staphylococcus aureus: genetic basis. Microbiol Rev. 1987 Mar;51(1):88–134. doi: 10.1128/mr.51.1.88-134.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Marton A., Gulyas M., Munoz R., Tomasz A. Extremely high incidence of antibiotic resistance in clinical isolates of Streptococcus pneumoniae in Hungary. J Infect Dis. 1991 Mar;163(3):542–548. doi: 10.1093/infdis/163.3.542. [DOI] [PubMed] [Google Scholar]
  8. Mulligan M. E., Murray-Leisure K. A., Ribner B. S., Standiford H. C., John J. F., Korvick J. A., Kauffman C. A., Yu V. L. Methicillin-resistant Staphylococcus aureus: a consensus review of the microbiology, pathogenesis, and epidemiology with implications for prevention and management. Am J Med. 1993 Mar;94(3):313–328. doi: 10.1016/0002-9343(93)90063-u. [DOI] [PubMed] [Google Scholar]
  9. Muñoz R., Coffey T. J., Daniels M., Dowson C. G., Laible G., Casal J., Hakenbeck R., Jacobs M., Musser J. M., Spratt B. G. Intercontinental spread of a multiresistant clone of serotype 23F Streptococcus pneumoniae. J Infect Dis. 1991 Aug;164(2):302–306. doi: 10.1093/infdis/164.2.302. [DOI] [PubMed] [Google Scholar]
  10. Rhinehart E., Smith N. E., Wennersten C., Gorss E., Freeman J., Eliopoulos G. M., Moellering R. C., Jr, Goldmann D. A. Rapid dissemination of beta-lactamase-producing, aminoglycoside-resistant Enterococcus faecalis among patients and staff on an infant-toddler surgical ward. N Engl J Med. 1990 Dec 27;323(26):1814–1818. doi: 10.1056/NEJM199012273232606. [DOI] [PubMed] [Google Scholar]
  11. Soares S., Kristinsson K. G., Musser J. M., Tomasz A. Evidence for the introduction of a multiresistant clone of serotype 6B Streptococcus pneumoniae from Spain to Iceland in the late 1980s. J Infect Dis. 1993 Jul;168(1):158–163. doi: 10.1093/infdis/168.1.158. [DOI] [PubMed] [Google Scholar]
  12. Speer B. S., Shoemaker N. B., Salyers A. A. Bacterial resistance to tetracycline: mechanisms, transfer, and clinical significance. Clin Microbiol Rev. 1992 Oct;5(4):387–399. doi: 10.1128/cmr.5.4.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Testa R. T., Petersen P. J., Jacobus N. V., Sum P. E., Lee V. J., Tally F. P. In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines. Antimicrob Agents Chemother. 1993 Nov;37(11):2270–2277. doi: 10.1128/aac.37.11.2270. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Wadsworth S. J., Kim K. H., Satishchandran V., Axelrod P., Truant A. L., Suh B. Development of new antibiotic resistance in methicillin-resistant but not methicillin-susceptible Staphylococcus aureus. J Antimicrob Chemother. 1992 Dec;30(6):821–826. doi: 10.1093/jac/30.6.821. [DOI] [PubMed] [Google Scholar]
  15. Yuk J. H., Dignani M. C., Harris R. L., Bradshaw M. W., Williams T. W., Jr Minocycline as an alternative antistaphylococcal agent. Rev Infect Dis. 1991 Sep-Oct;13(5):1023–1024. doi: 10.1093/clinids/13.5.1023. [DOI] [PubMed] [Google Scholar]

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