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. 1994 Aug;38(8):1834–1837. doi: 10.1128/aac.38.8.1834

Albendazole inhibits Pneumocystis carinii proliferation in inoculated immunosuppressed mice.

M S Bartlett 1, T D Edlind 1, C H Lee 1, R Dean 1, S F Queener 1, M M Shaw 1, J W Smith 1
PMCID: PMC284645  PMID: 7986016

Abstract

Albendazole, a benzimidazole derivative widely used for treating helminth infections, was successfully used to treat and prevent development of Pneumocystis carinii pneumonia in transtracheally inoculated immunosuppressed mice. For treatment, 3 weeks postinoculation, albendazole at 300 and 600 mg/kg of body weight per day was administered in food for 3 weeks. For prophylaxis, albendazole was begun on the same day as inoculation at 300 mg/kg/day for 7 days, and then the dose was reduced to 150 mg/kg/day for 35 additional days. With these regimens, albendazole was effective both for treatment and prophylaxis. Both dexamethasone-immunosuppressed and L3T4+ monoclonal antibody-immunosuppressed mouse models were used, and albendazole inhibited P. carinii infection in both.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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