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. 1994 Sep;38(9):2054–2058. doi: 10.1128/aac.38.9.2054

Metronidazole is bactericidal to dormant cells of Mycobacterium tuberculosis.

L G Wayne 1, H A Sramek 1
PMCID: PMC284683  PMID: 7811018

Abstract

Very abrupt exposure to anaerobic conditions has a lethal effect on actively growing cultures of Mycobacterium tuberculosis. However, incubation under conditions in which oxygen is depleted gradually causes M. tuberculosis to shift down from active replication to dormancy. The dormant bacilli are resistant to the bactericidal effects of anaerobiosis and also exhibit partial or complete resistance to the bactericidal effects of isoniazid and rifampin. On the other hand, metronidazole, a drug specific for anaerobes, kills dormant tubercle bacilli under anaerobic conditions, but it has no effect on actively growing aerobic cultures. The lethal effect of metronidazole under anaerobic conditions is enhanced by rifampin. The possible implications of these findings on the phenomenon of latency in tuberculosis are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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