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. 1971 May;106(2):297–300. doi: 10.1128/jb.106.2.297-300.1971

Differential Recovery of Auxotrophs After Penicillin Enrichment in Escherichia coli

John J Rossi 1, Claire M Berg 1
PMCID: PMC285095  PMID: 4929854

Abstract

Various auxotrophs are recovered from a penicillin enrichment cycle with differing efficiencies. Reconstruction experiments indicate that, under starvation conditions in the presence of penicillin, most auxotrophs undergo some death, whereas prolineless mutants are virtually immune to penicillin-induced killing.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baich A. Inhibitory effect of penicillin on proline synthesis in Escherichia coli. J Bacteriol. 1969 Nov;100(2):969–973. doi: 10.1128/jb.100.2.969-973.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. CURTIS S. R., 3rd CHROMOSOMAL ABERRATIONS ASSOCIATED WITH MUTATIONS TO BACTERIOPHAGE RESISTANCE IN ESCHERICHIA COLI. J Bacteriol. 1965 Jan;89:28–40. doi: 10.1128/jb.89.1.28-40.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Curtiss R., 3rd, Charamella L. J., Berg C. M., Harris P. E. Kinetic and genetic analyses of D-cycloserine inhibition and resistance in Escherichia coli. J Bacteriol. 1965 Nov;90(5):1238–1250. doi: 10.1128/jb.90.5.1238-1250.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Davis B. D. The Isolation of Biochemically Deficient Mutants of Bacteria by Means of Penicillin. Proc Natl Acad Sci U S A. 1949 Jan;35(1):1–10. doi: 10.1073/pnas.35.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. GALE E. F. Assimilation of amino acids by Gram-positive bacteria and some actions of antibiotics thereon. Adv Protein Chem. 1953;8:285–391. doi: 10.1016/s0065-3233(08)60094-7. [DOI] [PubMed] [Google Scholar]
  6. GOTS J. S., KOH W. Y., HUNT G. R., Jr Tryptophan metabolism and its relation to phage resistance in Escherichia coli. J Gen Microbiol. 1954 Aug;11(1):7–16. doi: 10.1099/00221287-11-1-7. [DOI] [PubMed] [Google Scholar]
  7. Kaback H. R., Stadtman E. R. Proline uptake by an isolated cytoplasmic membrane preparation of Escherichia coli. Proc Natl Acad Sci U S A. 1966 Apr;55(4):920–927. doi: 10.1073/pnas.55.4.920. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. LENNOX E. S. Transduction of linked genetic characters of the host by bacteriophage P1. Virology. 1955 Jul;1(2):190–206. doi: 10.1016/0042-6822(55)90016-7. [DOI] [PubMed] [Google Scholar]
  9. Lederberg J. BACTERIAL PROTOPLASTS INDUCED BY PENICILLIN. Proc Natl Acad Sci U S A. 1956 Sep;42(9):574–577. doi: 10.1073/pnas.42.9.574. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lieb M. Forward and Reverse Mutation in a Histidine-Requiring Strain of Escherichia Coli. Genetics. 1951 Sep;36(5):460–477. doi: 10.1093/genetics/36.5.460. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. PARK J. T., STROMINGER J. L. Mode of action of penicillin. Science. 1957 Jan 18;125(3238):99–101. doi: 10.1126/science.125.3238.99. [DOI] [PubMed] [Google Scholar]
  12. PRESTIDGE L. S., PARDEE A. B. Induction of bacterial lysis by penicillin. J Bacteriol. 1957 Jul;74(1):48–59. doi: 10.1128/jb.74.1.48-59.1957. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Signer E. R. Interaction of prophages at the att80 site with the chromosome of Escherichia coli. J Mol Biol. 1966 Jan;15(1):243–255. doi: 10.1016/s0022-2836(66)80224-3. [DOI] [PubMed] [Google Scholar]
  14. TRUCCO R. E., PARDEE A. B. Synthesis of Escherichia coli cell walls in the presence of penicillin. J Biol Chem. 1958 Jan;230(1):435–446. [PubMed] [Google Scholar]
  15. Taylor A. L. Current linkage map of Escherichia coli. Bacteriol Rev. 1970 Jun;34(2):155–175. doi: 10.1128/br.34.2.155-175.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. VOGEL H. J., BONNER D. M. Acetylornithinase of Escherichia coli: partial purification and some properties. J Biol Chem. 1956 Jan;218(1):97–106. [PubMed] [Google Scholar]
  17. Wise E. M., Jr, Park J. T. Penicillin: its basic site of action as an inhibitor of a peptide cross-linking reaction in cell wall mucopeptide synthesis. Proc Natl Acad Sci U S A. 1965 Jul;54(1):75–81. doi: 10.1073/pnas.54.1.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. YANOFSKY C., LENNOX E. S. Transduction and recombination study of linkage relationships among the genes controlling tryptophan synthesis in Escherichia coli. Virology. 1959 Aug;8:425–447. doi: 10.1016/0042-6822(59)90046-7. [DOI] [PubMed] [Google Scholar]

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