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. 1973 Jun;114(3):1068–1073. doi: 10.1128/jb.114.3.1068-1073.1973

Cyclic Adenosine 3′,5′-Monophosphate in Escherichia coli

M J Buettner a,1, Eva Spitz a, H V Rickenberg a
PMCID: PMC285366  PMID: 4351386

Abstract

The concentration of cyclic adenosine 3′,5′-monophosphate (c-AMP) in Escherichia coli growing on different sources of carbon was studied. Cultures utilizing a source of carbon that supported growth relatively poorly had consistently higher concentrations of c-AMP than did cultures utilizing sugars that supported rapid growth. This relationship was also observed in strains defective in c-AMP phosphodiesterase and simultaneously resistant to catabolite repression; in such strains the c-AMP concentration was slightly higher for several sources of carbon tested. Cultures continued to synthesize c-AMP and secreted it into the medium, under conditions that brought about an inhibition of the intracellular accumulation of the cyclic nucleotide. Transient repression of the synthesis of β-galactosidase was not associated with an abrupt decrease in the cellular concentration of c-AMP.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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