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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1969 Sep;64(1):95–99. doi: 10.1073/pnas.64.1.95

NERVE MEMBRANE CURRENT NOISE: DIRECT MEASUREMENTS UNDER VOLTAGE CLAMP*

Denis J M Poussart 1,†
PMCID: PMC286131  PMID: 5263026

Abstract

Fluctuations in the steady-state current of the membrane of the lobster giant axon have been measured under voltage-clamp conditions. These fluctuations have a power density spectrum that is inversely proportional to frequency. The magnitude of the fluctuations is determined largely by the potassium component of the membrane current.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRINLEY F. J., Jr SODIUM, POTASSIUM, AND CHLORIDE CONCENTRATIONS AND FLUXES IN THE ISOLATED GIANT AXON OF HOMARUS. J Neurophysiol. 1965 Jul;28:742–772. doi: 10.1152/jn.1965.28.4.742. [DOI] [PubMed] [Google Scholar]
  2. Blaustein M. P., Goldman D. E. Competitive action of calcium and procaine on lobster axon. A study of the mechanism of action of certain local anesthetics. J Gen Physiol. 1966 May;49(5):1043–1063. doi: 10.1085/jgp.49.5.1043. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Derksen H. E. Axon membrane voltage fluctuations. Acta Physiol Pharmacol Neerl. 1965;13(4):373–466. [PubMed] [Google Scholar]
  4. Derksen H. E., Verveen A. A. Fluctuations of resting neural membrane potential. Science. 1966 Mar 18;151(3716):1388–1389. doi: 10.1126/science.151.3716.1388. [DOI] [PubMed] [Google Scholar]
  5. FRANKENHAEUSER B. The effect of calcium on the myelinated nerve fibre. J Physiol. 1957 Jul 11;137(2):245–260. doi: 10.1113/jphysiol.1957.sp005809. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. JULIAN F. J., MOORE J. W., GOLDMAN D. E. Membrane potentials of the lobster giant axon obtained by use of the sucrose-gap technique. J Gen Physiol. 1962 Jul;45:1195–1216. doi: 10.1085/jgp.45.6.1195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Junge D., Moore G. P. Interspike interval fluctuations in aplysia pacemaker neurons. Biophys J. 2008 Dec 31;6(4):411–434. doi: 10.1016/S0006-3495(66)86667-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Moore G. P., Perkel D. H., Segundo J. P. Statistical analysis and functional interpretation of neuronal spike data. Annu Rev Physiol. 1966;28:493–522. doi: 10.1146/annurev.ph.28.030166.002425. [DOI] [PubMed] [Google Scholar]
  9. Verveen A. A., Derksen H. E., Schick K. L. Voltage fluctuations of neural membrane. Nature. 1967 Nov 11;216(5115):588–589. doi: 10.1038/216588a0. [DOI] [PubMed] [Google Scholar]

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