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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1970 Jan;65(1):200–205. doi: 10.1073/pnas.65.1.200

Topological Relationship of Prophage λ to the Bacterial Chromosome in Lysogenic Cells

David Freifelder 1,2, Matthew Meselson 1,2
PMCID: PMC286210  PMID: 4905668

Abstract

X irradiation converts bacterial sex factor DNA covalent circles to more slowly sedimenting forms according to first order kinetics. The rate of conversion is greater for sex factors carrying λ prophage than it is for nonlysogenized sex factors. The magnitude of the difference and the absence of covalent circular DNA from the product show that the prophage DNA is linearly inserted into the sex factor, as predicted by Campbell's model for lysogenization.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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