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. 1986 Nov;60(2):431–435. doi: 10.1128/jvi.60.2.431-435.1986

Prevention of simian acquired immune deficiency syndrome with a formalin-inactivated type D retrovirus vaccine.

P A Marx, N C Pedersen, N W Lerche, K G Osborn, L J Lowenstine, A A Lackner, D H Maul, H S Kwang, J D Kluge, C P Zaiss, et al.
PMCID: PMC288910  PMID: 3021978

Abstract

Experimental induction of simian acquired immune deficiency syndrome (SAIDS) by inoculation of juvenile rhesus monkeys with a type D retrovirus was prevented by immunization with Formalin-killed whole SAIDS retrovirus serotype 1 containing the adjuvant threonyl muramyl-dipeptide. All six immunized animals developed neutralizing antibody after three injections, while six age-matched cagemates receiving adjuvant alone were antibody free. All 12 monkeys were challenged intravenously with a potentially lethal dose of SAIDS retrovirus serotype 1. The six immunized animals failed to develop persistent viremia and remained clinically normal 8 months postchallenge. In contrast, five of six nonvaccinates developed persistent viremia, four of six developed clinical SAIDS, and two of six died with SAIDS at 10 weeks and 8 months postchallenge, respectively. These results show that prevention of a common spontaneous retrovirus-induced immunosuppressive disease in macaques is now possible by vaccination.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bryant M. L., Marx P. A., Shiigi S. M., Wilson B. J., McNulty W. P., Gardner M. B. Distribution of type D retrovirus sequences in tissues of macaques with simian acquired immune deficiency and retroperitoneal fibromatosis. Virology. 1986 Apr 15;150(1):149–160. doi: 10.1016/0042-6822(86)90274-6. [DOI] [PubMed] [Google Scholar]
  2. Bryant M. L., Yamamoto J., Luciw P., Munn R., Marx P., Higgins J., Pedersen N., Levine A., Gardner M. B. Molecular comparison of retroviruses associated with human and simian AIDS. Hematol Oncol. 1985 Jul-Sep;3(3):187–197. doi: 10.1002/hon.2900030307. [DOI] [PubMed] [Google Scholar]
  3. Daniel M. D., King N. W., Letvin N. L., Hunt R. D., Sehgal P. K., Desrosiers R. C. A new type D retrovirus isolated from macaques with an immunodeficiency syndrome. Science. 1984 Feb 10;223(4636):602–605. doi: 10.1126/science.6695172. [DOI] [PubMed] [Google Scholar]
  4. Daniel M. D., Letvin N. L., King N. W., Kannagi M., Sehgal P. K., Hunt R. D., Kanki P. J., Essex M., Desrosiers R. C. Isolation of T-cell tropic HTLV-III-like retrovirus from macaques. Science. 1985 Jun 7;228(4704):1201–1204. doi: 10.1126/science.3159089. [DOI] [PubMed] [Google Scholar]
  5. Gonda M. A., Wong-Staal F., Gallo R. C., Clements J. E., Narayan O., Gilden R. V. Sequence homology and morphologic similarity of HTLV-III and visna virus, a pathogenic lentivirus. Science. 1985 Jan 11;227(4683):173–177. doi: 10.1126/science.2981428. [DOI] [PubMed] [Google Scholar]
  6. Henrickson R. V., Maul D. H., Osborn K. G., Sever J. L., Madden D. L., Ellingsworth L. R., Anderson J. H., Lowenstine L. J., Gardner M. B. Epidemic of acquired immunodeficiency in rhesus monkeys. Lancet. 1983 Feb 19;1(8321):388–390. doi: 10.1016/s0140-6736(83)91503-9. [DOI] [PubMed] [Google Scholar]
  7. Kanki P. J., Alroy J., Essex M. Isolation of T-lymphotropic retrovirus related to HTLV-III/LAV from wild-caught African green monkeys. Science. 1985 Nov 22;230(4728):951–954. doi: 10.1126/science.2997923. [DOI] [PubMed] [Google Scholar]
  8. Kanki P. J., McLane M. F., King N. W., Jr, Letvin N. L., Hunt R. D., Sehgal P., Daniel M. D., Desrosiers R. C., Essex M. Serologic identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III. Science. 1985 Jun 7;228(4704):1199–1201. doi: 10.1126/science.3873705. [DOI] [PubMed] [Google Scholar]
  9. Letvin N. L., Eaton K. A., Aldrich W. R., Sehgal P. K., Blake B. J., Schlossman S. F., King N. W., Hunt R. D. Acquired immunodeficiency syndrome in a colony of macaque monkeys. Proc Natl Acad Sci U S A. 1983 May;80(9):2718–2722. doi: 10.1073/pnas.80.9.2718. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Levy J. A., Hoffman A. D., Kramer S. M., Landis J. A., Shimabukuro J. M., Oshiro L. S. Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS. Science. 1984 Aug 24;225(4664):840–842. doi: 10.1126/science.6206563. [DOI] [PubMed] [Google Scholar]
  11. Marx P. A., Maul D. H., Osborn K. G., Lerche N. W., Moody P., Lowenstine L. J., Henrickson R. V., Arthur L. O., Gilden R. V., Gravell M. Simian AIDS: isolation of a type D retrovirus and transmission of the disease. Science. 1984 Mar 9;223(4640):1083–1086. doi: 10.1126/science.6695196. [DOI] [PubMed] [Google Scholar]
  12. Maul D. H., Lerche N. W., Osborn K. G., Marx P. A., Zaiss C., Spinner A., Kluge J. D., MacKenzie M. R., Lowenstine L. J., Bryant M. L. Pathogenesis of simian AIDS in rhesus macaques inoculated with the SRV-1 strain of type D retrovirus. Am J Vet Res. 1986 Apr;47(4):863–868. [PubMed] [Google Scholar]
  13. Munn R. J., Marx P. A., Yamamoto J. K., Gardner M. B. Ultrastructural comparison of the retroviruses associated with human and simian acquired immunodeficiency syndromes. Lab Invest. 1985 Aug;53(2):194–199. [PubMed] [Google Scholar]
  14. Murphey-Corb M., Martin L. N., Rangan S. R., Baskin G. B., Gormus B. J., Wolf R. H., Andes W. A., West M., Montelaro R. C. Isolation of an HTLV-III-related retrovirus from macaques with simian AIDS and its possible origin in asymptomatic mangabeys. Nature. 1986 May 22;321(6068):435–437. doi: 10.1038/321435a0. [DOI] [PubMed] [Google Scholar]
  15. Osborn K. G., Prahalada S., Lowenstine L. J., Gardner M. B., Maul D. H., Henrickson R. V. The pathology of an epizootic of acquired immunodeficiency in rhesus macaques. Am J Pathol. 1984 Jan;114(1):94–103. [PMC free article] [PubMed] [Google Scholar]
  16. Power M. D., Marx P. A., Bryant M. L., Gardner M. B., Barr P. J., Luciw P. A. Nucleotide sequence of SRV-1, a type D simian acquired immune deficiency syndrome retrovirus. Science. 1986 Mar 28;231(4745):1567–1572. doi: 10.1126/science.3006247. [DOI] [PubMed] [Google Scholar]
  17. Shiigi S. M., Wilson B. J., Malley A., Howard C. F., Jr, McNulty W. P., Olson L., Olson S., Regan D., Burger D., Marx P. A. Virus-associated deficiencies in the mitogen reactivity in celebes black macaques (Macaca nigra). Clin Immunol Immunopathol. 1985 May;35(2):200–210. doi: 10.1016/0090-1229(85)90066-2. [DOI] [PubMed] [Google Scholar]
  18. Sonigo P., Alizon M., Staskus K., Klatzmann D., Cole S., Danos O., Retzel E., Tiollais P., Haase A., Wain-Hobson S. Nucleotide sequence of the visna lentivirus: relationship to the AIDS virus. Cell. 1985 Aug;42(1):369–382. doi: 10.1016/s0092-8674(85)80132-x. [DOI] [PubMed] [Google Scholar]
  19. Sonigo P., Barker C., Hunter E., Wain-Hobson S. Nucleotide sequence of Mason-Pfizer monkey virus: an immunosuppressive D-type retrovirus. Cell. 1986 May 9;45(3):375–385. doi: 10.1016/0092-8674(86)90323-5. [DOI] [PubMed] [Google Scholar]
  20. Stromberg K., Benveniste R. E., Arthur L. O., Rabin H., Giddens W. E., Jr, Ochs H. D., Morton W. R., Tsai C. C. Characterization of exogenous type D retrovirus from a fibroma of a macaque with simian AIDS and fibromatosis. Science. 1984 Apr 20;224(4646):289–282. doi: 10.1126/science.6200929. [DOI] [PubMed] [Google Scholar]

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