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. 1962 Jan;41(1):67–79. doi: 10.1172/JCI104468

HUMAN LEUKOCYTE METABOLISM IN VITRO. I. INCORPORATION OF ADENINE-8-C14 AND FORMATE-C14 INTO THE NUCLEIC ACIDS OF LEUKEMIC LEUKOCYTES

James L Scott 1
PMCID: PMC289195  PMID: 13909938

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AMOS H., MAGASANIK B. Uridine as precursor of bacteriophage thymidylic acid. J Biol Chem. 1957 Dec;229(2):653–657. [PubMed] [Google Scholar]
  2. ATHENS J. W., MAUER A. M., ASHENBRUCKER H., CARTWRIGHT G. E., WINTROBE M. M. Leukokinetic studies. I. A method for labeling leukocytes with diisopropyl-fluorophosphate (DFP32). Blood. 1959 Apr;14(4):303–333. [PubMed] [Google Scholar]
  3. BOLINDER A., REICHARD P. The biosynthesis of deoxyribonucleic acid by the chick embryo. III. Influence of vitamin B12 deficiency. J Biol Chem. 1959 Oct;234:2723–2727. [PubMed] [Google Scholar]
  4. BOND V. P., FLIEDNER T. M., CRONKITE E. P., RUBINI J. R., BRECHER G., SCHORK P. K. Proliferative potentials of bone marrow and blood cells studied by in vitro uptake of H3-thymidine. Acta Haematol. 1959 Jan;21(1):1–15. doi: 10.1159/000205651. [DOI] [PubMed] [Google Scholar]
  5. BROCKMAN R. W. A mechanism of resistance to 6-mercaptopurine: metabolism of hypoxanthine and 6-mercaptopurine by sensitive and resistant neoplasms. Cancer Res. 1960 Jun;20:643–653. [PubMed] [Google Scholar]
  6. CHAKRABORTY K. P., LORING H. S. Incorporation of uracil-2-C14 into the nucleic acids of Neurospora crassa. J Biol Chem. 1960 Jul;235:2122–2126. [PubMed] [Google Scholar]
  7. CONZELMAN G. M., Jr, MANDEL H. G., SMITH P. K. The incorporation of radiocarbon from 4-amino-5-imidazolecarboxamide into the purines of tumor-bearing mice. J Biol Chem. 1953 Mar;201(1):329–334. [PubMed] [Google Scholar]
  8. CRADDOCK C. G., Jr, PERRY S., LAWRENCE J. S. The dynamics of leukopoiesis and leukocytosis, as studied by leukopheresis and isotopic techniques. J Clin Invest. 1956 Mar;35(3):285–296. doi: 10.1172/JCI103276. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. CRADDOCK C. G., Jr The physiology of granulocytic cells in normal and leukemic states. Am J Med. 1960 May;28:711–725. doi: 10.1016/0002-9343(60)90129-7. [DOI] [PubMed] [Google Scholar]
  10. DAVIDSON J. D. Studies on the mechanism of action of 6-mercaptopurine in sensitive and resistant L1210 leukemia in vitro. Cancer Res. 1960 Feb;20:225–232. [PubMed] [Google Scholar]
  11. DAVIDSON J. N., LESLIE I., WHITE J. C. The nucleic-acid content of the cell. Lancet. 1951 Jun 16;1(6668):1287–1290. doi: 10.1016/s0140-6736(51)91768-0. [DOI] [PubMed] [Google Scholar]
  12. DUERST M. L., JUMP M. E., OSGOOD E. E., RIGAS D. A. The nucleic acids and other phosphorus compounds of human leukemic leukocytes: relation to cell maturity. J Lab Clin Med. 1956 Sep;48(3):356–378. [PubMed] [Google Scholar]
  13. ELION G. B., BIEBER S., HITCHINGS G. H. The fate of 6-mercaptopurine in mice. Ann N Y Acad Sci. 1954 Dec 6;60(2):297–303. doi: 10.1111/j.1749-6632.1954.tb40020.x. [DOI] [PubMed] [Google Scholar]
  14. FRENSTER J. H., BEST W. R., WINZLER R. J. Metabolism of human leukocytes in vitro. V. Inhibition by human serum of formate and glycine incorporations. Proc Soc Exp Biol Med. 1958 Aug-Sep;98(4):887–890. doi: 10.3181/00379727-98-24218. [DOI] [PubMed] [Google Scholar]
  15. FRIEDKIN M., ROBERTS D. Conversion of uracil deoxyriboside to thymidine of deoxyribonucleic acid. J Biol Chem. 1956 Jun;220(2):653–660. [PubMed] [Google Scholar]
  16. GAVOSTO F., MARAINI G., PILERI A. Proliferative capacity of acute leukaemia cells. Nature. 1960 Aug 13;187:611–612. doi: 10.1038/187611a0. [DOI] [PubMed] [Google Scholar]
  17. GREULICH R. C., CAMERON I. L., THRASHER J. D. Stimulation of mitosis in adult mice by administration of thymidine. Proc Natl Acad Sci U S A. 1961 Jun 15;47:743–748. doi: 10.1073/pnas.47.6.743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. HARTMAN S. C., BUCHANAN J. M. Nucleic acids, purines, pyrimidines (nucleotide synthesis). Annu Rev Biochem. 1959;28:365–410. doi: 10.1146/annurev.bi.28.070159.002053. [DOI] [PubMed] [Google Scholar]
  19. HEINRICH M. R., WILSON D. W. The biosynthesis of nucleic acid components studied with C14. I. Purines and pyrimidines in the rat. J Biol Chem. 1950 Oct;186(2):447–460. [PubMed] [Google Scholar]
  20. LAJTHA L. G. Bone marrow cell metabolism. Physiol Rev. 1957 Jan;37(1):50–65. doi: 10.1152/physrev.1957.37.1.50. [DOI] [PubMed] [Google Scholar]
  21. MALEY F., MALEY G. F. Nucleotide interconversions. II. Elevation of deoxycytidylate deaminase and thymidylate synthetase in regenerating rat liver. J Biol Chem. 1960 Oct;235:2968–2970. [PubMed] [Google Scholar]
  22. PILERI A., MARAINI G., GAVOSTO F. Interrelationship between RNA and protein metabolism in human normal bone marrow cells. Exp Cell Res. 1960 Sep;20:645–646. doi: 10.1016/0014-4827(60)90148-8. [DOI] [PubMed] [Google Scholar]
  23. SALZMAN N. P., EAGLE H., SEBRING E. D. The utilization of glutamine, glutamic acid, and ammonia for the biosynthesis of nucleic acid bases in mammalian cell cultures. J Biol Chem. 1958 Feb;230(2):1001–1012. [PubMed] [Google Scholar]
  24. SMITH L. H., Jr, BAKER F. A., SULLIVAN M. Pyrimidine metabolism in man. II. Studies of leukemic cells. Blood. 1960 Mar;15:360–369. [PubMed] [Google Scholar]
  25. THOMAS E. D., LOCHTE H. L., Jr Desoxyribonucleic acid synthesis by bone marrow cells in vitro. Blood. 1957 Dec;12(12):1086–1095. [PubMed] [Google Scholar]
  26. WELLS W., WINZLER R. J. Metabolism of human leukocytes in vitro. III. Incorporation of formate-C14 into cellular components of leukemic human leukocytes. Cancer Res. 1959 Nov;19:1086–1090. [PubMed] [Google Scholar]
  27. WILLIAMS A. M., LEPAGE G. A. Purine metabolism in mouse ascites tumor cells. II. In vitro incorporation of performed purines into nucleotides and polynucleotides. Cancer Res. 1958 Jun;18(5):554–561. [PubMed] [Google Scholar]
  28. WINZLER R. J. Differences in nucleic acid metabolism between normal and leukemic human leukocytes. Ann N Y Acad Sci. 1958 Oct 13;75(1):37–44. doi: 10.1111/j.1749-6632.1958.tb36849.x. [DOI] [PubMed] [Google Scholar]
  29. WINZLER R. J., WILLIAMS A. D., BEST W. R. Metabolism of human leukocytes in vitro. I. Effects of A-methopterin on formate-C14 incorporation. Cancer Res. 1957 Feb;17(2):108–116. [PubMed] [Google Scholar]
  30. WYNGAARDEN J. B. Intermediary purine metabolism and the metabolic defects of gout. Metabolism. 1957 May;6(3):244–268. [PubMed] [Google Scholar]

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