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. 1963 Feb;42(2):143–160. doi: 10.1172/JCI104701

OBSERVATIONS CONCERNING THE BINDING OF THYROID HORMONES BY HUMAN SERUM PREALBUMIN*

Sidney H Ingbar 1,
PMCID: PMC289263  PMID: 13956488

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALLISON A. C. Identification of human serum proteins binding iron, copper, and thyroid hormones by starch gel electrophoresis. Experientia. 1959 Jul 15;15:281–284. doi: 10.1007/BF02158085. [DOI] [PubMed] [Google Scholar]
  2. ANDREOLI M., ANDREANI D. L'elettroforesi continua applicata allo studio degli ormoni iodati radioattivi. Minerva Nucl. 1959 May;3(5):161–164. [PubMed] [Google Scholar]
  3. AUSTEN F. K., RUBINI M. E., MERONEY W. H., WOLFF J. Salicylates and thyroid function. I. Depression of thyroid function. J Clin Invest. 1958 Aug;37(8):1131–1143. doi: 10.1172/JCI103703. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BEIERWALTES W. H., ROBBINS J. Familial increase in the thyroxine-binding sites in serum alpha globulin. J Clin Invest. 1959 Oct;38:1683–1688. doi: 10.1172/JCI103946. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BLUMBERG B. S., ROBBINS J. Thyroxine-serum protein complexes: single dimension gel and paper electrophoresis studies. Endocrinology. 1960 Sep;67:368–378. doi: 10.1210/endo-67-3-368. [DOI] [PubMed] [Google Scholar]
  6. CASTOR C. W., BEIERWALTES W. Effect of 2, 4-dinitrophenol on thyroid function in man. J Clin Endocrinol Metab. 1956 Aug;16(8):1026–1031. doi: 10.1210/jcem-16-8-1026. [DOI] [PubMed] [Google Scholar]
  7. CHRISTENSEN L. K., LITONJUA A. D. Is thyroxine binding by pre-albumin of physiologic importance? J Clin Endocrinol Metab. 1961 Jan;21:104–106. doi: 10.1210/jcem-21-1-104. [DOI] [PubMed] [Google Scholar]
  8. CHRISTENSEN L. K. The binding to serum protein of acetic and propionic acid analogues of thyroxine and triiodothyronine. Endocrinology. 1960 Sep;67:407–412. doi: 10.1210/endo-67-3-407. [DOI] [PubMed] [Google Scholar]
  9. CHRISTENSEN L. K. Thyroxine-releasing effect of salicylate and of 2,4-dinitrophenol. Nature. 1959 Apr 25;183(4669):1189–1190. doi: 10.1038/1831189a0. [DOI] [PubMed] [Google Scholar]
  10. CRISPELL K. R., COLEMAN J., HYER H. Factors affecting the binding capacity of human erythrocytes for I131-labeled 1-thyroxine and 1-triiodothyronine. J Clin Endocrinol Metab. 1957 Nov;17(11):1305–1312. doi: 10.1210/jcem-17-11-1305. [DOI] [PubMed] [Google Scholar]
  11. DOWLING J. T., HUTCHINSON D. L., HINDLE W. R., KLEEMAN C. R. Effects of pregnancy of iodine metabolism in the primate. J Clin Endocrinol Metab. 1961 Jul;21:779–791. doi: 10.1210/jcem-21-7-779. [DOI] [PubMed] [Google Scholar]
  12. GAVRILESCO K., COURCON J., HILLION P., URIEL J., LEWIN J., GRABAR P. A study of normal human cerebrospinal fluid by the immuno-electrophoretic mentod. Nature. 1955 Nov 19;176(4490):976–976. doi: 10.1038/176976a0. [DOI] [PubMed] [Google Scholar]
  13. HAMOLSKY M. W., FISCHER D. B., FREEDBERG A. S. Further studies on the plasma protein-thyroid hormone complex. Endocrinology. 1960 May;66:780–783. doi: 10.1210/endo-66-5-780. [DOI] [PubMed] [Google Scholar]
  14. HETZEL B. S., GOOD B. F., WELLBY M. L., BEGG M. W. The effect of salicylate on the plasma protein-bound iodine level in various states of endocrine disorder in man. Australas Ann Med. 1962 Feb;11:34–40. doi: 10.1111/imj.1962.11.1.34. [DOI] [PubMed] [Google Scholar]
  15. HETZEL B. S., GOOD B. F., WELLBY M. L., CHARNOCK J. S. Salicylate-induced fall in plasma protein-bound iodine in hyperthyroidism. Lancet. 1960 Apr 30;1(7131):957–959. doi: 10.1016/s0140-6736(60)90839-4. [DOI] [PubMed] [Google Scholar]
  16. HOCH H., CHANUTIN A. Electrophoretic studies on fast moving components of human serum. J Biol Chem. 1953 Jan;200(1):241–249. [PubMed] [Google Scholar]
  17. HOLLANDER C. S., ODAK V. V., PROUT T. E., ASPER S. P., Jr An evaluation of the role of prealbumin in the binding of thyroxine. J Clin Endocrinol Metab. 1962 Jun;22:617–622. doi: 10.1210/jcem-22-6-617. [DOI] [PubMed] [Google Scholar]
  18. INGBAR S. H., FREINKEL N. Regulation of the peripheral metabolism of the thyroid hormones. Recent Prog Horm Res. 1960;16:353–403. [PubMed] [Google Scholar]
  19. INGBAR S. H. Pre-albumin: a thyroxinebinding protein of human plasma. Endocrinology. 1958 Aug;63(2):256–259. doi: 10.1210/endo-63-2-256. [DOI] [PubMed] [Google Scholar]
  20. INGBAR S. H. The interaction of the thyroid hormones with the proteins of human plasma. Ann N Y Acad Sci. 1960 Apr 23;86:440–453. doi: 10.1111/j.1749-6632.1960.tb42821.x. [DOI] [PubMed] [Google Scholar]
  21. Ingbar S. H. CLINICAL AND PHYSIOLOGICAL OBSERVATIONS IN A PATIENT WITH AN IDIOPATHIC DECREASE IN THE THYROXINE-BINDING GLOBULIN OF PLASMA. J Clin Invest. 1961 Nov;40(11):2053–2063. doi: 10.1172/JCI104431. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. LARSON F. C., ALBRIGHT E. C. The specificity of thyroxine binding by serum alpha globulin. Endocrinology. 1955 Jun;56(6):737–741. doi: 10.1210/endo-56-6-737. [DOI] [PubMed] [Google Scholar]
  23. MYANT N. B., OSORIO C. Paper electrophoresis of thyroxine in tris-maleate buffer. J Physiol. 1960 Jul;152:601–612. doi: 10.1113/jphysiol.1960.sp006511. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. PORATH J. Methodological studies of zone-electrophoresis in vertical columns. I. Fractionation in cellulose powder columns of substances of low molecular weight exemplified by amino acids and related compounds. Biochim Biophys Acta. 1956 Oct;22(1):151–175. doi: 10.1016/0006-3002(56)90234-7. [DOI] [PubMed] [Google Scholar]
  25. POULIK M. D., SMITHIES O. Comparison and combination of the starch-gel and filter-paper electrophoretic methods applied to human sera: two-dimensional electrophoresis. Biochem J. 1958 Apr;68(4):636–643. doi: 10.1042/bj0680636. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. ROBBINS J., RALL J. E. Effects of triiodothyronine and other thyroxine analogues on thyroxine-binding in human serum. J Clin Invest. 1955 Aug;34(8):1331–1336. doi: 10.1172/JCI103180. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. ROBBINS J., RALL J. E. Proteins associated with the thyroid hormones. Physiol Rev. 1960 Jul;40:415–489. doi: 10.1152/physrev.1960.40.3.415. [DOI] [PubMed] [Google Scholar]
  28. ROBBINS J., RALL J. E. The interaction of thyroid hormones and protein in biological fluids. Recent Prog Horm Res. 1957;13:161–208. [PubMed] [Google Scholar]
  29. SCHONENBERGER M., SCHULTZE H. E., SCHWICK G. Uber ein Präalbumin des menschlichen Serums. Biochem Z. 1956;328(4):267–284. [PubMed] [Google Scholar]
  30. SMITHIES O. Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. Biochem J. 1955 Dec;61(4):629–641. doi: 10.1042/bj0610629. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. TANAKA S., STARR P. The binding of thyroxine analogues by human serum protein. Acta Endocrinol (Copenh) 1959 Jun;31(2):161–170. doi: 10.1530/acta.0.xxxi0161. [DOI] [PubMed] [Google Scholar]
  32. TATA J. R. A new aspect of the interaction between thyroxine and proteins. Biochem J. 1959 Jun;72(2):222–229. doi: 10.1042/bj0720222. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. TATA J. R. Nature of thyroxine-binding globulin in human serum. Nature. 1961 Feb 18;189:573–574. doi: 10.1038/189573a0. [DOI] [PubMed] [Google Scholar]
  34. TATA J. R. Prealbumin as a complex in the alpha-globulin fraction in human serum. Nature. 1959 Mar 28;183(4665):877–879. doi: 10.1038/183877a0. [DOI] [PubMed] [Google Scholar]
  35. TATA J. R., WIDNELL C. C., GRATZER W. B. A systematic study of factors affecting the binding of thyroxine and related substances to serum proteins. Clin Chim Acta. 1961 Sep;6:597–612. doi: 10.1016/0009-8981(61)90102-4. [DOI] [PubMed] [Google Scholar]
  36. WOLFF J., AUSTEN F. K. Salicylates and thyroid function. II. The effect on the thyroid-pituitary interrelation. J Clin Invest. 1958 Aug;37(8):1144–1152. doi: 10.1172/JCI103704. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. WOLFF J., STANDAERT M. E., RALL J. E. Thyroxine displacement from serum proteins and depression of serum protein-bound iodine by certain drugs. J Clin Invest. 1961 Aug;40:1373–1379. doi: 10.1172/JCI104368. [DOI] [PMC free article] [PubMed] [Google Scholar]

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