Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1963 Oct;42(10):1619–1631. doi: 10.1172/JCI104847

SECRETION RATE OF ALDOSTERONE IN NORMAL PREGNANCY*

Mamoru Watanabe 1,2,3,†, C Irving Meeker 1,2,3,‡, Mary Jane Gray 1,2,3, Ethan A H Sims 1,2,3, Samuel Solomon 1,2,3
PMCID: PMC289441  PMID: 14074356

Full text

PDF
1623

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARNES A. C., QUILLIGAN E. J. Measurements of aldosterone in the eclamptogenic toxemias of pregnancy. Am J Obstet Gynecol. 1956 Mar;71(3):670–682. doi: 10.1016/0002-9378(56)90492-6. [DOI] [PubMed] [Google Scholar]
  2. BAULIEU E. E., DE VIGAN M., BRICAIRE H., JAYLE M. F. Lack of plasma cortisol and urinary aldosterone in a pregnant woman with Addison's disease. J Clin Endocrinol Metab. 1957 Dec;17(12):1478–1482. doi: 10.1210/jcem-17-12-1478. [DOI] [PubMed] [Google Scholar]
  3. CHART J. J., SHIPLEY E. G., GORDON E. S. Evidence for a sodium retaining factor in toxemia of pregnancy. Proc Soc Exp Biol Med. 1951 Oct;78(1):244–246. doi: 10.3181/00379727-78-19035. [DOI] [PubMed] [Google Scholar]
  4. CHRISTY N. P., JAILER J. W. Failure to demonstrate hydrocortisone and aldosterone during pregnancy in Addison's disease. J Clin Endocrinol Metab. 1959 Feb;19(2):263–266. doi: 10.1210/jcem-19-2-263. [DOI] [PubMed] [Google Scholar]
  5. COPPAGE W. S., Jr, ISLAND D. P., COONER A. E., LIDDLE G. W. The metabolism of aldosterone in normal subjects and in patients with hepatic cirrhosis. J Clin Invest. 1962 Aug;41:1672–1680. doi: 10.1172/JCI104624. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. DAVEY D. A., O'SULLIVAN W. J., BROWNE J. C. Total exchangeable sodium in normal pregnancy and in preeclampsia. Lancet. 1961 Mar 11;1(7176):519–523. doi: 10.1016/s0140-6736(61)91597-5. [DOI] [PubMed] [Google Scholar]
  7. DAVIS J. O., BALL W. C., Jr Effects of a body cast on aldosterone and sodium excretion in dogs with experimental ascites. Am J Physiol. 1958 Mar;192(3):538–542. doi: 10.1152/ajplegacy.1958.192.3.538. [DOI] [PubMed] [Google Scholar]
  8. DAVIS J. O., KLIMAN B., YANKOPOULOS N. A., PETERSON R. E. Increased aldosterone secretion following acute constriction of the inferior vena cava. J Clin Invest. 1958 Dec;37(12):1783–1790. doi: 10.1172/JCI103771. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. DIECKMANN W. J., POTTINGER R. E. Etiology of pre-eclampsia-eclampsia. V. Extra- and intracellular fluid changes and electrolyte balances. Am J Obstet Gynecol. 1955 Oct;70(4):822–860. doi: 10.1016/s0002-9378(16)37838-3. [DOI] [PubMed] [Google Scholar]
  10. FLOOD C., LAYNE D. S., RAMCHARAN S., ROSSIPAL E., TAIT J. F., TAIT S. A. An investigation of the urinary metabolites and secretion rates of aldosterone and cortisol in man and a description of methods for their measurement. Acta Endocrinol (Copenh) 1961 Feb;36:237–264. doi: 10.1530/acta.0.0360237. [DOI] [PubMed] [Google Scholar]
  11. GEMZELL C. A. Blood levels of 17-hydroxycorticosteroids in normal pregnancy. J Clin Endocrinol Metab. 1953 Aug;13(8):898–902. doi: 10.1210/jcem-13-8-898. [DOI] [PubMed] [Google Scholar]
  12. GORDON E. S., CHART J. J., HAGEDORN D., SHIPLEY E. G. Mechanism of sodium retention in preeclamptic toxemia. Obstet Gynecol. 1954 Jul;4(1):39–50. [PubMed] [Google Scholar]
  13. HARE R. S. Endogenous creatinine in serum and urine. Proc Soc Exp Biol Med. 1950 May;74(1):148–151. doi: 10.3181/00379727-74-17837. [DOI] [PubMed] [Google Scholar]
  14. JONES K. M., LLOYD-JONES R., RIONDEL A., TAIT J. F., TAIT S. A., BULBROOK R. D., GREENWOOD F. C. Aldosterone secretion and metabolism in normal men and women and in pregnancy. Acta Endocrinol (Copenh) 1959 Mar;30(3):321–342. doi: 10.1530/acta.0.0300321. [DOI] [PubMed] [Google Scholar]
  15. KOCZOREK K. R., WOLFF H. P., BEER M. L. Uber die Aldosteronausscheidung bei Schwangerschaften und bei Schwangerschaftstoxikosen. Klin Wochenschr. 1957 May 15;35(10):497–502. doi: 10.1007/BF01480886. [DOI] [PubMed] [Google Scholar]
  16. KUMAR D., FELTHAM L. A., GORNALL A. G. Aldosterone excretion and tissue electrolytes in normal pregnancy and pre-eclampsia. Lancet. 1959 Mar 14;1(7072):541–545. doi: 10.1016/s0140-6736(59)92309-8. [DOI] [PubMed] [Google Scholar]
  17. LAIDLAW J. C., COHEN M., GORNALL A. G. Studies on the origin of aldosterone during human pregnancy. J Clin Endocrinol Metab. 1958 Feb;18(2):222–225. doi: 10.1210/jcem-18-2-222. [DOI] [PubMed] [Google Scholar]
  18. LAIDLAW J. C., RUSE J. L., GORNALL A. G. The influence of estrogen and progesterone on aldosterone excretion. J Clin Endocrinol Metab. 1962 Feb;22:161–171. doi: 10.1210/jcem-22-2-161. [DOI] [PubMed] [Google Scholar]
  19. LANDAU R. L., BERGENSTAL D. M., LUGIBIHL K., KASCHT M. E. The metabolic effects of progesterone in man. J Clin Endocrinol Metab. 1955 Oct;15(10):1194–1215. doi: 10.1210/jcem-15-10-1194. [DOI] [PubMed] [Google Scholar]
  20. LANDAU R. L., LUGIBIHL K., BERGENSTAL D. M., DIMICK D. F. The metabolic effects of progesterone in man: dose response relationships. J Lab Clin Med. 1957 Oct;50(4):613–620. [PubMed] [Google Scholar]
  21. LANDAU R. L., LUGIBIHL K. Inhibition of the sodium-retaining influence of aldosterone by progesterone. J Clin Endocrinol Metab. 1958 Nov;18(11):1237–1245. doi: 10.1210/jcem-18-11-1237. [DOI] [PubMed] [Google Scholar]
  22. LANDAU R. L., PLOTZ E. J., LUGIBIHL K. Effect of pregnancy on the metabolic influence of administered progesterone. J Clin Endocrinol Metab. 1960 Dec;20:1561–1567. doi: 10.1210/jcem-20-12-1561. [DOI] [PubMed] [Google Scholar]
  23. LAYNE D. S., MEYER C. J., VAISHWANAR P. S., PINCUS G. The secretion and metabolism of cortisol and aldosterone in normal and in steroid-treated women. J Clin Endocrinol Metab. 1962 Feb;22:107–118. doi: 10.1210/jcem-22-2-107. [DOI] [PubMed] [Google Scholar]
  24. LICHTON I. J. Salt saving in the pregnant rat. Am J Physiol. 1961 Nov;201:765–768. doi: 10.1152/ajplegacy.1961.201.5.765. [DOI] [PubMed] [Google Scholar]
  25. LUETSCHER J. A., DOWDY A. J., CALLAGHAN A. M., COHN A. P. Studies of secretion and metabolism of aldosterone and cortisol. Trans Assoc Am Physicians. 1962;75:293–300. [PubMed] [Google Scholar]
  26. LUETSCHER J. A., Jr, AXELRAD B. J. Increased aldosterone output during sodium deprivation in normal men. Proc Soc Exp Biol Med. 1954 Dec;87(3):650–653. doi: 10.3181/00379727-87-21472. [DOI] [PubMed] [Google Scholar]
  27. MARTIN J. D., MILLS I. H. Aldosterone excretion in normal and toxaemic pregnancies. Br Med J. 1956 Sep 8;2(4992):571–573. doi: 10.1136/bmj.2.4992.571. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. MILLS J. N. Aldosterone secretion in man. Br Med Bull. 1962 May;18:170–173. doi: 10.1093/oxfordjournals.bmb.a069960. [DOI] [PubMed] [Google Scholar]
  29. NOWACZYNSKI W., GOLDNER M., GENEST J. Microdetermination of corticosteroids with tetrazolium derivatives. J Lab Clin Med. 1955 May;45(5):818–821. [PubMed] [Google Scholar]
  30. PEARLMAN W. H., CERCEO E. The isolation of progesterone from human placenta. J Biol Chem. 1952 Sep;198(1):79–83. [PubMed] [Google Scholar]
  31. PLENTL A. A., GRAY M. J. Total body water, sodium space, and total exchangeable sodium in normal and toxemic pregnant women. Am J Obstet Gynecol. 1959 Sep;78:472–478. doi: 10.1016/0002-9378(59)90515-0. [DOI] [PubMed] [Google Scholar]
  32. RINSLER M. G., RIGBY B. Function of aldosterone in the metabolism of sodium and water in pregnancy. Br Med J. 1957 Oct 26;2(5051):966–969. doi: 10.1136/bmj.2.5051.966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. SIMS E. A., KRANTZ K. E. Serial studies of renal function during pregnancy and the puerperium in normal women. J Clin Invest. 1958 Dec;37(12):1764–1774. doi: 10.1172/JCI103769. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. SKEGGS L. T., Jr An automatic method for colorimetric analysis. Am J Clin Pathol. 1957 Sep;28(3):311–322. doi: 10.1093/ajcp/28.3_ts.311. [DOI] [PubMed] [Google Scholar]
  35. SLAUNWHITE W. R., Jr, SANDBERG A. A. Transcortin: a corticosteroid-binding protein of plasma. J Clin Invest. 1959 Feb;38(2):384–391. doi: 10.1172/JCI103812. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. TYSOE F. W., LOWENSTEIN L., SIMON F. Blood volume and hematologic studies in pregnancy and the puerperium. Am J Obstet Gynecol. 1950 Dec;60(6):1187–1205. doi: 10.1016/0002-9378(50)90001-9. [DOI] [PubMed] [Google Scholar]
  37. ULICK S., LARAGH J. H., LIEBERMAN S. The isolation of a urinary metabolite of aldosterone and its use to measure the rate of secretion of aldosterone by the adrenal cortex of man. Trans Assoc Am Physicians. 1958;71:225–235. [PubMed] [Google Scholar]
  38. ULICK S. Stereospecificity in the metabolism of aldosterone in man. J Biol Chem. 1961 Mar;236:680–684. [PubMed] [Google Scholar]
  39. VENNING E. H., DYRENFURTH I. Aldosterone excretion in pregnancy. J Clin Endocrinol Metab. 1956 Mar;16(3):426–428. doi: 10.1210/jcem-16-3-426. [DOI] [PubMed] [Google Scholar]
  40. VENNING E. H., DYRENFURTH I., LOWENSTEIN L., BECK J. Metabolic studies in pregnancy and the puerperium. J Clin Endocrinol Metab. 1959 Apr;19(4):403–424. doi: 10.1210/jcem-19-4-403. [DOI] [PubMed] [Google Scholar]
  41. VENNING E. H., PRIMROSE T., CALIGARIS L. C., DYRENFURTH I. Aldosterone excretion in pregnancy. J Clin Endocrinol Metab. 1957 Apr;17(4):473–482. doi: 10.1210/jcem-17-4-473. [DOI] [PubMed] [Google Scholar]
  42. VENNING E. H., SINGER B., SIMPSON G. A. Adrenocortical function in toxemia of pregnancy. Am J Obstet Gynecol. 1954 Mar;67(3):542–548. doi: 10.1016/0002-9378(54)90044-7. [DOI] [PubMed] [Google Scholar]
  43. VENNING E. H., SYBULSKI S., POLLAK V. E., RYAN R. J. Aldosterone excretion in two adrenalectomized pregnant women. J Clin Endocrinol Metab. 1959 Nov;19:1486–1491. doi: 10.1210/jcem-19-11-1486. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES