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. 1963 Dec;42(12):1913–1921. doi: 10.1172/JCI104877

STUDIES ON NORMAL AND LEUKEMIC LEUKOCYTES. VI. THYMIDYLATE SYNTHETASE AND DEOXYCYTIDYLATE DEAMINASE*

Robert Silber 1,, Beverly W Gabrio 1, F M Huennekens 1,
PMCID: PMC289479  PMID: 14086778

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARNER H. D., COHEN S. S. Virus-induced acquisition of metabolic function. IV. Thymidylate synthetase in thymine-requiring Escherichia coli infected by T2 and T5 bacteriophages. J Biol Chem. 1959 Nov;234:2987–2991. [PubMed] [Google Scholar]
  2. BERTINO J. R., SILBER R., FREEMAN M., ALENTY A., ALBRECHT M., GABRIO B. W., HUENNEKENS F. M. STUDIES ON NORMAL AND LEUKEMIC LEUKOCYTES. IV. TETRAHYDROFOLATE-DEPENDENT ENZYME SYSTEMS AND DIHYDROFOLIC REDUCTASE. J Clin Invest. 1963 Dec;42:1899–1907. doi: 10.1172/JCI104875. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BIANCHI P. A. Thymidine phosphorylation and deoxyribonucleic acid synthesis in human leukaemic cells. Biochim Biophys Acta. 1962 Apr 2;55:547–549. doi: 10.1016/0006-3002(62)90989-7. [DOI] [PubMed] [Google Scholar]
  4. BLAKLEY R. L., McDOUGALL B. M. The biosynthesis of thymidylic acid. III. Purification of thymidylate synthetase and its spectrophotometric assay. J Biol Chem. 1962 Mar;237:812–818. [PubMed] [Google Scholar]
  5. CRADDOCK C. G., NAKAI G. S. Leukemic cell proliferation as determined by in vitro deoxyribonucleic acid synthesis. J Clin Invest. 1962 Feb;41:360–369. doi: 10.1172/JCI104490. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. FLAKS J. G., COHEN S. S. Virus-induced acquisition of metabolic function. I. Enzymatic formation of 5-hydroxymethyldeoxycytidylate. J Biol Chem. 1959 Jun;234(6):1501–1506. [PubMed] [Google Scholar]
  7. GAVOSTO F., MARAINI G., PILERI A. Proliferative capacity of acute leukaemia cells. Nature. 1960 Aug 13;187:611–612. doi: 10.1038/187611a0. [DOI] [PubMed] [Google Scholar]
  8. HARTMANN K. U., HEIDELBERGER C. Studies on fluorinated pyrimidines. XIII. Inhibition of thymidylate synthetase. J Biol Chem. 1961 Nov;236:3006–3013. [PubMed] [Google Scholar]
  9. MALEY F., MALEY G. F. Nucleotide interconversions. II. Elevation of deoxycytidylate deaminase and thymidylate synthetase in regenerating rat liver. J Biol Chem. 1960 Oct;235:2968–2970. [PubMed] [Google Scholar]
  10. MALEY G. F., MALEY F. Nucleotide interconversions in embryonic and neoplastic tissues. I. The conversion of deoxycytidylic acid to deoxyuridylic acid and thymidylic acid. J Biol Chem. 1959 Nov;234:2975–2980. [PubMed] [Google Scholar]
  11. MCDOUGALL B. M., BLAKLEY R. L. The biosynthesis of thymidylic acid. I. Preliminary studies with extracts of Streptococcus faecalis R. J Biol Chem. 1961 Mar;236:832–837. [PubMed] [Google Scholar]
  12. O'BRIEN J. S. The role of the folate coenzymes in cellular division. A review. Cancer Res. 1962 Apr;22:267–281. [PubMed] [Google Scholar]
  13. REICHARD P. Biochemical changes during treatment with 5-fluorouracil. Cancer Chemother Rep. 1962 Feb;16:347–352. [PubMed] [Google Scholar]
  14. SCOTT J. L. Human leukocyte metabolism in vitro. I. Incorporation of adenine-8-C-14 and formate-C-14 into the nucleic acids of leukemic leukocytes. J Clin Invest. 1962 Jan;41:67–79. doi: 10.1172/JCI104468. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. SMITH L. H., Jr, BAKER F. A., SULLIVAN M. Pyrimidine metabolism in man. II. Studies of leukemic cells. Blood. 1960 Mar;15:360–369. [PubMed] [Google Scholar]
  16. WAHBA A. J., FRIEDKIN M. The enzymatic synthesis of thymidylate. I. Early steps in the purification of thymidylate synthetase of Escherichia coli. J Biol Chem. 1962 Dec;237:3794–3801. [PubMed] [Google Scholar]
  17. WINZLER R. J., WILLIAMS A. D., BEST W. R. Metabolism of human leukocytes in vitro. I. Effects of A-methopterin on formate-C14 incorporation. Cancer Res. 1957 Feb;17(2):108–116. [PubMed] [Google Scholar]

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