Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1964 May;43(5):797–809. doi: 10.1172/JCI104966

Effect of Serotonin on Glycogen Metabolism in Isolated Rat Liver*

Robert A Levine 1,2,†, Leroy A Pesch 1,2,‡, Gerald Klatskin 1,2, Nicholas J Giarman 1,2
PMCID: PMC289559  PMID: 14169509

Full text

PDF
799

Images in this article

801Image
on p.801
805Image
on p.805

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AMIN A. H., CRAWFORD T. B., GADDUM J. H. The distribution of substance P and 5-hydroxytryptamine in the central nervous system of the dog. J Physiol. 1954 Dec 10;126(3):596–618. doi: 10.1113/jphysiol.1954.sp005229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BRAUER R. W. Liver circulation and function. Physiol Rev. 1963 Jan;43:115–213. doi: 10.1152/physrev.1963.43.1.115. [DOI] [PubMed] [Google Scholar]
  3. CHIANDUSSI L., GRECO F., INDOVINA D., CESANO L., VACCARINO A., MURATORI F. Effect of drug infusion on splanchnic circulation. II. Serotonin infusion in normal and cirrhotic subjects. Proc Soc Exp Biol Med. 1963 Feb;112:326–328. doi: 10.3181/00379727-112-28031. [DOI] [PubMed] [Google Scholar]
  4. COLOMBO J. P., WEBER J. W., GUIDOTTI G., KANAMEISHI D., FOA P. P. Liver phosphorylase in normal and adrenalectomized dogs treated with serotonin. Endocrinology. 1960 Nov;67:693–697. doi: 10.1210/endo-67-5-693. [DOI] [PubMed] [Google Scholar]
  5. CORRELL J. T., LYTH F., LONG S., VANDERPOEL J. C. Some physiologic responses to 5-hydroxytryptamine creatinine sulfate. Am J Physiol. 1952 Jun;169(3):537–544. doi: 10.1152/ajplegacy.1952.169.3.537. [DOI] [PubMed] [Google Scholar]
  6. FELDBERG W., SMITH A. N. Release of histamine by tryptamine and 5-hydroxytryptamine. Br J Pharmacol Chemother. 1953 Dec;8(4):406–411. doi: 10.1111/j.1476-5381.1953.tb01338.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. GALANSINO G., D'AMICO G., KANAMEISHI D., BERLINGER F. G., FOA P. P. Hyperglycemic substances orginating in the pancreatoduodenal area. Am J Physiol. 1960 May;198:1059–1062. doi: 10.1152/ajplegacy.1960.198.5.1059. [DOI] [PubMed] [Google Scholar]
  8. GREEN M., MILLER L. L. Protein catabolism and protein synthesis in perfused livers of normal and alloxan-diabetic rats. J Biol Chem. 1960 Nov;235:3202–3208. [PubMed] [Google Scholar]
  9. HADDY F. J., FLEISHMAN M., EMANUEL D. A. Effect of epinephrine, norepinephrine and serotonin upon systemic small and large vessel resistance. Circ Res. 1957 May;5(3):247–251. doi: 10.1161/01.res.5.3.247. [DOI] [PubMed] [Google Scholar]
  10. HAGEN P. The storage and release of catecholamines. Pharmacol Rev. 1959 Jun;11(2 Pt 2):361–373. [PubMed] [Google Scholar]
  11. HESSE R., DEMLING L., ZICHA L., SCHMID E. [Experimental animal studies on the portal circulation]. Gastroenterologia. 1960;94:102–113. [PubMed] [Google Scholar]
  12. JINKS R., MIRSKY I. A., PERISUTTI G. The hypoglycemic action of metabolic derivatives of L-tryptophan by mouth. Endocrinology. 1957 Feb;60(2):318–324. doi: 10.1210/endo-60-2-318. [DOI] [PubMed] [Google Scholar]
  13. KOBAYASHI B., UI M., WARASHINA Y. The role of serotonin in carbohydrate metabolism. I. Glycemic effect of serotonin in rats. Endocrinol Jpn. 1960 Sep;7:225–238. doi: 10.1507/endocrj1954.7.225. [DOI] [PubMed] [Google Scholar]
  14. KOBAYASHI B., UI M., WARASHINA Y. The role of serotonin in carbohydrate metabolism. II. The effect of serotonin on glycogen content of liver, heart and diaphragm in rats. Endocrinol Jpn. 1960 Sep;7:239–248. doi: 10.1507/endocrj1954.7.239. [DOI] [PubMed] [Google Scholar]
  15. MANSOUR T. E. Effect of serotonin on glycolysis in homogenates from the liver fluke Fasciola hepatica. J Pharmacol Exp Ther. 1962 Jan;135:94–101. [PubMed] [Google Scholar]
  16. MANSOUR T. E., MANSOUR J. M. Effects of serotonin (5-hydroxytryptamine) and adenosine 3',5'-phosphate on phosphofructokinase from the liver fluke Fasciola hepatica. J Biol Chem. 1962 Mar;237:629–634. [PubMed] [Google Scholar]
  17. MANSOUR T. E., SUTHERLAND E. W., RALL T. W., BUEDING E. The effect of serotonin (5-hydroxytryptamine) on the formation of adenosine 3',5'-phosphate by tissue particles from the liver fluke, Fasciola hepatica. J Biol Chem. 1960 Feb;235:466–470. [PubMed] [Google Scholar]
  18. MANSOUR T. E. The effect of serotonin and related compounds on the carbohydrate metabolism of the liver fluke, Fasciola hepatica. J Pharmacol Exp Ther. 1959 Jul;126(3):212–216. [PubMed] [Google Scholar]
  19. MILLER L. L., BLY C. G., WATSON M. L., BALE W. F. The dominant role of the liver in plasma protein synthesis; a direct study of the isolated perfused rat liver with the aid of lysine-epsilon-C14. J Exp Med. 1951 Nov;94(5):431–453. doi: 10.1084/jem.94.5.431. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. REID G. Circulatory effects of 5-hydroxytryptamine. J Physiol. 1952 Dec;118(4):435–453. doi: 10.1113/jphysiol.1952.sp004806. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. SCALTRINI G. C. Il quadro emocitario periferico e la glicemia dopo 5-idrossitriptamina. Haematologica. 1956;41(9):681–687. [PubMed] [Google Scholar]
  22. SIREK A. Nature and site of origin of the hyperglycaemic substance released following an injection of growth hormone. Nature. 1957 Feb 16;179(4555):376–376. doi: 10.1038/179376a0. [DOI] [PubMed] [Google Scholar]
  23. SOKAL J. E., MILLER L. L., SARCIONE E. J. Glycogen metabolism in the isolated liver. Am J Physiol. 1958 Nov;195(2):295–300. doi: 10.1152/ajplegacy.1958.195.2.295. [DOI] [PubMed] [Google Scholar]
  24. TWAROG B. M., PAGE I. H. Serotonin content of some mammalian tissues and urine and a method for its determination. Am J Physiol. 1953 Oct;175(1):157–161. doi: 10.1152/ajplegacy.1953.175.1.157. [DOI] [PubMed] [Google Scholar]
  25. VAUGHAN M. Effect of hormones on phosphorylase activity in adipose tissue. J Biol Chem. 1960 Nov;235:3049–3053. [PubMed] [Google Scholar]
  26. WEITZEL G., ROESTER U., BUDDECKE E., STRECKER F. J. Zinkgehalt und blutzuckersteigernde Wirkung von Organextrakten. Hoppe Seylers Z Physiol Chem. 1956 Mar 17;303(3-6):161–175. [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES