Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1961 Apr;40(4):656–664. doi: 10.1172/JCI104298

PYRIMIDINE METABOLISM IN MAN. IV. THE ENZYMATIC DEFECT OF OROTIC ACIDURIA*

Lloyd H Smith Jr 1,2, Margaret Sullivan 1,2, Charles M Huguley Jr 1,2
PMCID: PMC290771  PMID: 16695858

Full text

PDF
664

Images in this article

661Image
on p.661

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLAIR D. G., STONE J. E., POTTER V. R. Formation of orotidine 5'-phosphate by enzymes from rat liver. J Biol Chem. 1960 Aug;235:2379–2386. [PubMed] [Google Scholar]
  2. FINCHAM J. R. Genetically controlled differences in enzyme activity. Adv Enzymol Relat Subj Biochem. 1960;22:1–43. doi: 10.1002/9780470122679.ch1. [DOI] [PubMed] [Google Scholar]
  3. HANDSCHUMACHER R. E. Orotidylic acid decarboxylase: inhibition studies with azauridine 5'-phosphate. J Biol Chem. 1960 Oct;235:2917–2919. [PubMed] [Google Scholar]
  4. HEPPEL L. A., HILMORE R. J. Purification and properties of 5-nucleotidase. J Biol Chem. 1951 Feb;188(2):665–676. [PubMed] [Google Scholar]
  5. HOLMES W. L. Studies on the mode of action of analogues of orotic acid; 6-uracilsulfonic acid, 6-uracilsulfonamide, and 6-uracil methyl sulfone. J Biol Chem. 1956 Dec;223(2):677–686. [PubMed] [Google Scholar]
  6. HUGULEY C. M., Jr, BAIN J. A., RIVERS S. L., SCOGGINS R. B. Refractory megaloblastic anemia associated with excretion of orotic acid. Blood. 1959 Jun;14(6):615–634. [PubMed] [Google Scholar]
  7. KORNBERG A., LIEBERMAN I., SIMMS E. S. Enzymatic synthesis and properties of 5-phosphoribosylpyrophosphate. J Biol Chem. 1955 Jul;215(1):389–402. [PubMed] [Google Scholar]
  8. LIEBERMAN I., KORNBERG A., SIMMS E. S. Enzymatic synthesis of pyrimidine nucleotides; orotidine-5'-phosphate and uridine-5'-phosphate. J Biol Chem. 1955 Jul;215(1):403–451. [PubMed] [Google Scholar]
  9. PARDEE A. B., YATES R. A. Pyrimidine biosynthesis in Escherichia coli. J Biol Chem. 1956 Aug;221(2):743–756. [PubMed] [Google Scholar]
  10. RAMOT B., FISHER S., SZEINBERG A., ADAM A., SHEBA C., GAFNI D. A study of subjects with erythrocyte glucose-6-phosphate dehydrogenase deficiency. II. Investigation of leukocyte enzymes. J Clin Invest. 1959 Dec;38:2234–2237. doi: 10.1172/JCI104004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. RAMOT B., SHEBA C., ADAM A., ASHKENASI I. Erythrocyte glucose-6-phosphate dehydrogenase-deficient subjects: enzyme-level in saliva. Nature. 1960 Mar 26;185:931–931. doi: 10.1038/185931a0. [DOI] [PubMed] [Google Scholar]
  12. REICHARD P., SKOLD O. Enzymes of uracil metabolism in the Ehrlich ascites tumour and mammalian liver. Biochim Biophys Acta. 1958 May;28(2):376–385. doi: 10.1016/0006-3002(58)90485-2. [DOI] [PubMed] [Google Scholar]
  13. SMITH L. H., Jr, BAKER F. A. Pyrimidine metabolism in man. I. The biosynthesis of orotic acid. J Clin Invest. 1959 May;38(5):798–809. doi: 10.1172/JCI103862. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. SMITH L. H., Jr, BAKER F. A. Pyrimidine metabolism in man. III. Studies on leukocytes and erythrocytes in pernicious anemia. J Clin Invest. 1960 Jan;39:15–20. doi: 10.1172/JCI104013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. YATES R. A., PARDEE A. B. Control by uracil of formation of enzymes required for orotate synthesis. J Biol Chem. 1957 Aug;227(2):677–692. [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES