Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1961 Jul;40(7):1304–1314. doi: 10.1172/JCI104360

URIC ACID PRODUCTION IN GOUT

J E Seegmiller 1, Arthur I Grayzel 1, Leonard Laster 1, Lois Liddle 1
PMCID: PMC290843  PMID: 13749616

Full text

PDF
1307

Images in this article

1306Image
on p.1306
1306Image
on p.1306
1308Image
on p.1308

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARONOFF A. Acute gouty arthritis precipitated by chlorothiazide. N Engl J Med. 1960 Apr 14;262:767–769. doi: 10.1056/NEJM196004142621507. [DOI] [PubMed] [Google Scholar]
  2. BENEDICT J. D., FORSHAM P. H., ROCHE M., SOLOWAY S., STETTEN D., Jr The effect of salicylates and adrenocorticotropic hormone upon the miscible pool of uric acid in gout. J Clin Invest. 1950 Aug;29(8):1104–1111. doi: 10.1172/JCI102343. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BENEDICT J. D., FORSHAM P. H., STETTEN D., Jr The metabolism of uric acid in the normal and gouty human studied with the aid of isotopic uric acid. J Biol Chem. 1949 Nov;181(1):183–193. [PubMed] [Google Scholar]
  4. BENEDICT J. D., KALINSKY H. J., SCARRONE L. A., WERTBEIM A. R., STETTEN D., Jr The origin of urinary creatine in progressive muscular dystrophy. J Clin Invest. 1955 Jan;34(1):141–145. doi: 10.1172/JCI103057. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BENEDICT J. D., ROCHE M., YU T. F., BIEN E. J., GUTMAN A. B., STETTEN D., Jr Incorporation of glycine nitrogen into uric acid in normal and gouty man. Metabolism. 1952 Jan;1(1):3–12. [PubMed] [Google Scholar]
  6. BENEDICT J. D., YU T. F., BIEN E. J., GUTMAN A. B., STETTEN D., Jr A further study of the utilization of dietary glycine nitrogen for uric acid synthesis in gout. J Clin Invest. 1953 Aug;32(8):775–777. doi: 10.1172/JCI102791. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. BIEN E. J., ZUCKER M. Uricolysis in normal and gouty individuals. Ann Rheum Dis. 1955 Dec;14(4):409–411. doi: 10.1136/ard.14.4.409. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. BISHOP C., GARNER W., TALBOTT J. H. Pool size, turnover rate, and rapidity of equilibration of injected isotopic uric acid in normal and pathological subjects. J Clin Invest. 1951 Aug;30(8):879–888. doi: 10.1172/JCI102504. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. CULLEN J. H., LEVINE M., FIORE J. M. Studies of hyperuricemia produced by pyrazinamide. Am J Med. 1957 Oct;23(4):587–595. doi: 10.1016/0002-9343(57)90229-2. [DOI] [PubMed] [Google Scholar]
  10. GRAYZEL A. I., SEEGMILLER J. E., LOVE E. Suppression of uric acid synthesis in the gouty human by the use of 6-diazo-5-oxo-L-norleucine. J Clin Invest. 1960 Mar;39:447–454. doi: 10.1172/JCI104057. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. GUTMAN A. B., YU T. F., BLACK H., YALOW R. S., BERSON S. A. Incorporation of glycine-1-C14, glycine-2-C14 and glycine-N15 into uric acid in normal and gouty subjects. Am J Med. 1958 Dec;25(6):917–932. doi: 10.1016/0002-9343(58)90063-9. [DOI] [PubMed] [Google Scholar]
  12. GUTMAN A. B., YU T. F. Renal function in gout; with a commentary on the renal regulation of urate excretion, and the role of the kidney in the pathogenesis of gout. Am J Med. 1957 Oct;23(4):600–622. doi: 10.1016/0002-9343(57)90231-0. [DOI] [PubMed] [Google Scholar]
  13. HANDLER J. S. The role of lactic acid in the reduced excretion of uric acid in toxemia of pregnancy. J Clin Invest. 1960 Oct;39:1526–1532. doi: 10.1172/JCI104172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. HEALEY L. A., MAGID G. J., DECKER J. L. Uric acid retention due to hydrochlorothiazide. N Engl J Med. 1959 Dec 31;261:1358–1362. doi: 10.1056/NEJM195912312612702. [DOI] [PubMed] [Google Scholar]
  15. LIDDLE L., SEEGMILLER J. E., LASTER L. The enzymatic spectrophotometric method for determination of uric acid. J Lab Clin Med. 1959 Dec;54:903–913. [PubMed] [Google Scholar]
  16. NUGENT C. A., TYLER F. H. The renal excretion of uric acid in patients with gout and in nongouty subjects. J Clin Invest. 1959 Nov;38:1890–1898. doi: 10.1172/JCI103966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. OREN B. G., RICH M., BELLE M. S. Chlorothiazide (diuril) as a hyperuricaci'emic agent. J Am Med Assoc. 1958 Dec 20;168(16):2128–2129. doi: 10.1001/jama.1958.63000160005010a. [DOI] [PubMed] [Google Scholar]
  18. SEEGMILLER J. E., LASTER L., LIDDLE L. V. Failure to detect consistent overincorporation of glycine-1-C14 into uric acid in primary gout. Metabolism. 1958 Jul;7(4 Pt 1):376–377. [PubMed] [Google Scholar]
  19. SHAPIRO M., HYDE L. Hyperuricemia due to pyrazinamide. Am J Med. 1957 Oct;23(4):596–599. doi: 10.1016/0002-9343(57)90230-9. [DOI] [PubMed] [Google Scholar]
  20. SORENSEN L. B. Degradation of uric acid in man. Metabolism. 1959 Sep;8:687–703. [PubMed] [Google Scholar]
  21. WATTS R. W., CRAWHALL J. C. The first glycine metabolic pool in man. Biochem J. 1959 Oct;73:277–286. doi: 10.1042/bj0730277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. WYNGAARDEN J. B. Normal glycine-C14-incorporation into uric acid in primary gout. Metabolism. 1958 Jul;7(4 Pt 1):374–375. [PubMed] [Google Scholar]
  23. WYNGAARDEN J. B. Overproduction of uric acid as the cause of hyperuricemia in primary gout. J Clin Invest. 1957 Oct;36(10):1508–1515. doi: 10.1172/JCI103547. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. YU T. F., SIROTA J. H., BERGER L., HALPERN M., GUTMAN A. B. Effect of sodium lactate infusion on urate clearance in man. Proc Soc Exp Biol Med. 1957 Dec;96(3):809–813. doi: 10.3181/00379727-96-23616. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES