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. 1961 Sep;40(9):1597–1620. doi: 10.1172/JCI104383

IMMUNOREACTIONS INVOLVING PLATELETS. V. POST-TRANSFUSION PURPURA DUE TO A COMPLEMENT-FIXING ANTIBODY AGAINST A GENETICALLY CONTROLLED PLATELET ANTIGEN. A PROPOSED MECHANISM FOR THROMBOCYTOPENIA AND ITS RELEVANCE IN “AUTOIMMUNITY”*

N Raphael Shulman 1, Richard H Aster 1, Alfred Leitner 1, Merilyn C Hiller 1
PMCID: PMC290853  PMID: 16695867

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Selected References

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  1. ACKROYD J. F. Platelet agglutinins and lysins in the pathogenesis of thrombocytopenic purpura, with a note on platelet groups. Br Med Bull. 1955;11(1):28–35. doi: 10.1093/oxfordjournals.bmb.a069441. [DOI] [PubMed] [Google Scholar]
  2. ACKROYD J. F. The cause of thrombocytopenia in sedormid purpura. Clin Sci. 1949 Dec 19;8(4):269-89, incl pl. [PubMed] [Google Scholar]
  3. ALEXANDER W. R. The application of the fluorescent-antibody technique to haemagglutinating systems. Immunology. 1958 Jul;1(3):217–223. [PMC free article] [PubMed] [Google Scholar]
  4. ARIMURA G., HARRINGTON W. J., MINNICH V. The autoimmune thrombocytopenias. Prog Hematol. 1956;1:166–192. [PubMed] [Google Scholar]
  5. BILLINGHAM R. E., BRENT L., MEDAWAR P. B. Actively acquired tolerance of foreign cells. Nature. 1953 Oct 3;172(4379):603–606. doi: 10.1038/172603a0. [DOI] [PubMed] [Google Scholar]
  6. BRECHER G., CRONKITE E. P. Morphology and enumeration of human blood platelets. J Appl Physiol. 1950 Dec;3(6):365–377. doi: 10.1152/jappl.1950.3.6.365. [DOI] [PubMed] [Google Scholar]
  7. DAMESHEK W., SCHWARTZ R. S. Leukemia and auto-immunization- some possible relationships. Blood. 1959 Oct;14:1151–1158. [PubMed] [Google Scholar]
  8. DRAY S. Three gamma-globulins in normal human serum revealed by monkey precipitins. Science. 1960 Nov 4;132(3436):1313–1314. doi: 10.1126/science.132.3436.1313. [DOI] [PubMed] [Google Scholar]
  9. DUNSFORD I., BOWLEY C. C., HUTCHISON A. M., THOMPSON J. S., SANGER R., RACE R. R. A human blood-group chimera. Br Med J. 1953 Jul 11;2(4827):81–81. doi: 10.1136/bmj.2.4827.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. FUDENBERG H. H., KUNKEL H. G. Physical properties of the red cell agglutinins in acquired hemolytic anemia. J Exp Med. 1957 Nov 1;106(5):689–702. doi: 10.1084/jem.106.5.689. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. GILES C. M., MOURANT A. E., PARKIN D. M., HORLEY J. F., TAPSON K. J. A weak B antigen, probably acquired. Br Med J. 1959 Jul 11;2(5140):32–34. doi: 10.1136/bmj.2.5140.32. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. HILL T. L. Immunoreactions involving platelets. II. Theoretical analysis of the model. J Exp Med. 1958 May 1;107(5):691–695. doi: 10.1084/jem.107.5.691. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. HUGH-JONES K., MANFIELD P. A., BREWER H. F. Congenital thrombocytopenic purpura. Arch Dis Child. 1960 Apr;35:146–152. doi: 10.1136/adc.35.180.146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. MARSHALL J. D., EVELAND W. C., SMITH C. W. Superiority of fluorescein isothiocyanate (Riggs) for fluorescent-antibody technic with a modification of its application. Proc Soc Exp Biol Med. 1958 Aug-Sep;98(4):898–900. doi: 10.3181/00379727-98-24222. [DOI] [PubMed] [Google Scholar]
  15. MASOUREDIS S. P. Relationship between RhO(D) genotype and quantity of 1131 anti-RhO(D) bound to red cells. J Clin Invest. 1960 Sep;39:1450–1462. doi: 10.1172/JCI104164. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. MIESCHER P., MIESCHER A. Die Sedormid-Anaphylaxie. Schweiz Med Wochenschr. 1952 Dec 13;82(50):1279–1282. [PubMed] [Google Scholar]
  17. MORGAN W. T., WATKINS W. M. Some aspects of the biochemistry of the human blood-group substances. Br Med Bull. 1959 May;15(2):109–113. doi: 10.1093/oxfordjournals.bmb.a069732. [DOI] [PubMed] [Google Scholar]
  18. RIGGS J. L., SEIWALD R. J., BURCKHALTER J. H., DOWNS C. M., METCALF T. G. Isothiocyanate compounds as fluorescent labeling agents for immune serum. Am J Pathol. 1958 Nov-Dec;34(6):1081–1097. [PMC free article] [PubMed] [Google Scholar]
  19. SERCARZ E., COONS A. H. Specific inhibition of antibody formation during immunological paralysis and unresponsiveness. Nature. 1959 Oct 3;184(Suppl 14):1080–1082. doi: 10.1038/1841080a0. [DOI] [PubMed] [Google Scholar]
  20. SHEPPARD P. M. Blood groups and natural selection. Br Med Bull. 1959 May;15(2):134–139. doi: 10.1093/oxfordjournals.bmb.a069737. [DOI] [PubMed] [Google Scholar]
  21. SHULMAN N. R. Immunoreactions involving platelets. I. A steric and kinetic model for formation of a complex from a human antibody, quinidine as a haptene, and platelets; and for fixation of complement by the complex. J Exp Med. 1958 May 1;107(5):665–690. doi: 10.1084/jem.107.5.665. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. SHULMAN N. R. Immunoreactions involving platelets. III. Quantitative aspects of platelet agglutination, inhibition of clot retraction, and other reactions caused by the antibody of quinidine purpura. J Exp Med. 1958 May 1;107(5):697–710. doi: 10.1084/jem.107.5.697. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. SHULMAN N. R. Immunoreactions involving platelets. IV. Studies on the pathogenesis of thrombocytopenia in drug purpura using test doses of quinidine in sensitized individuals; their implications in idiopathic thrombocytopenic purpura. J Exp Med. 1958 May 1;107(5):711–729. doi: 10.1084/jem.107.5.711. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. SILBER R., BENITEZ R., EVELAND W. C., AKEROYD J. H., DUNNE C. J. The application of fluorescent antibody methods to the study of platelets. Blood. 1960 Jul;16:958–967. [PubMed] [Google Scholar]
  25. STEFFEN C. Results obtained with the antiglobulin consumption test and investigations of autoantibody eluates in immunohematology. J Lab Clin Med. 1960 Jan;55:9–28. [PubMed] [Google Scholar]
  26. Stormont C. Acquisition of the J Substance by the Bovine Erythrocyte. Proc Natl Acad Sci U S A. 1949 May;35(5):232–237. doi: 10.1073/pnas.35.5.232. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. VAZQUEZ J. J., LEWIS J. H. Immunocytochemical studies on platelets. The demonstration of a common antigen in human platelets and megakaryocytes. Blood. 1960 Jul;16:968–974. [PubMed] [Google Scholar]
  28. WARAVDEKAR V. S., SASLAW L. D. A method of estimation of 2-deoxyribose. Biochim Biophys Acta. 1957 May;24(2):439–439. doi: 10.1016/0006-3002(57)90224-x. [DOI] [PubMed] [Google Scholar]
  29. ZUCKER M. B., LEY A. B., BORRELLI J., MAYER K., FIRMAT J. Thrombocytopenia with a circulating platelet agglutinin, platelet agglutinin, platelet lysin and clot retraction inhibitor. Blood. 1959 Feb;14(2):148–161. [PubMed] [Google Scholar]

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