Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1962 Apr;41(4):871–883. doi: 10.1172/JCI104544

PYRIMIDINE METABOLISM IN MAN. V. THE MEASUREMENT IN VIVO OF THE BIOCHEMICAL EFFECT OF ANTINEOPLASTIC AGENTS IN ANIMAL AND HUMAN SUBJECTS*

Mitchell T Rabkin 1,2, Elizabeth W Frederick 1,2, Myron Lotz 1,2,†, Lloyd H Smith Jr 1,2
PMCID: PMC290989  PMID: 14489640

Full text

PDF
873

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADAMS W. S., DAVIS F., NAKATANI M. Purine and pyrimidine excretion in normal and leukemic subjects. Am J Med. 1960 May;28:726–734. doi: 10.1016/0002-9343(60)90130-3. [DOI] [PubMed] [Google Scholar]
  2. CANELLAKIS E. S. Pyrimidine metabolism. I. Enzymatic pathways of uracil and thymine degradation. J Biol Chem. 1956 Jul;221(1):315–322. [PubMed] [Google Scholar]
  3. CANELLAKIS E. S. Pyrimidine metabolism. II. Enzymatic pathways of uracil anabolism. J Biol Chem. 1957 Jul;227(1):329–338. [PubMed] [Google Scholar]
  4. CHAUDHURI N. K., MONTAG B. J., HEIDELBERGER C. Studies on fluorinated pyrimidines. III. The metabolism of 5-fluorouracil-2-C14 and 5-fluoroorotic-2-C14 acid in vivo. Cancer Res. 1958 Apr;18(3):318–328. [PubMed] [Google Scholar]
  5. CLARKE D. A., PHILIPS F. S., STERNBERG S. S., STOCK C. C., ELION G. B., HITCHINGS G. H. 6-Mercaptopurine: effects in mouse sarcoma 180 and in normal animals. Cancer Res. 1953 Aug;13(8):593–604. [PubMed] [Google Scholar]
  6. FERNANDES J. F., CASTELLANI O., PLESE M. Biosynthesis of histamine ribotide and imidazoleacetate ribotide. Biochem Biophys Res Commun. 1960 Dec;3:679–684. doi: 10.1016/0006-291x(60)90086-3. [DOI] [PubMed] [Google Scholar]
  7. FINK R. M., MCGAUGHEY C., CLINE R. E., FINK K. Metabolism of intermediate pyrimidine reduction products in vitro. J Biol Chem. 1956 Jan;218(1):1–7. [PubMed] [Google Scholar]
  8. GOTS J. S., GOLLUB E. G. Purine analogs as feedback inhibitors. Proc Soc Exp Biol Med. 1959 Aug-Sep;101:641–643. doi: 10.3181/00379727-101-25045. [DOI] [PubMed] [Google Scholar]
  9. HABERMANN V. Elimination by the urine of orotic acid and orotidine in man after application of 6-azauracil. Biochim Biophys Acta. 1960 Sep 9;43:137–138. doi: 10.1016/0006-3002(60)90420-0. [DOI] [PubMed] [Google Scholar]
  10. HANDSCHUMACHER R. E. Orotidylic acid decarboxylase: inhibition studies with azauridine 5'-phosphate. J Biol Chem. 1960 Oct;235:2917–2919. [PubMed] [Google Scholar]
  11. HANDSCHUMACHER R. E., PASTERNAK C. A. Inhibition of orotidylic acid decarboxylase, a primary site of carcinostasis by 6-azauracil. Biochim Biophys Acta. 1958 Nov;30(2):451–452. doi: 10.1016/0006-3002(58)90088-x. [DOI] [PubMed] [Google Scholar]
  12. HEIDELBERGER C., CHAUDHURI N. K., DANNEBERG P., MOOREN D., GRIESBACH L., DUSCHINSKY R., SCHNITZER R. J., PLEVEN E., SCHEINER J. Fluorinated pyrimidines, a new class of tumour-inhibitory compounds. Nature. 1957 Mar 30;179(4561):663–666. doi: 10.1038/179663a0. [DOI] [PubMed] [Google Scholar]
  13. HIATT H. H. Studies of ribose metabolism. V. Factors influencing in vivo ribose synthesis in the rat. J Clin Invest. 1958 Oct;37(10):1453–1460. doi: 10.1172/JCI103736. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. HURLBERT R. B., POTTER V. R. A survey of the metabolism of orotic acid in the rat. J Biol Chem. 1952 Mar;195(1):257–270. [PubMed] [Google Scholar]
  15. IMSANDE J., HANDLER P. Biosynthesis of diphosphopyridine nucleotide. III. Nicotinic acid mononucleotide pyrophos-phorylase. J Biol Chem. 1961 Feb;236:525–530. [PubMed] [Google Scholar]
  16. KAPLAN N. O., GOLDIN A., HUMPHREYS S. R., CIOTTI M. M., STOLZENBACH F. E. Pyridine nucleotide synthesis in the mouse. J Biol Chem. 1956 Mar;219(1):287–298. [PubMed] [Google Scholar]
  17. KRAKOFF I. H., BALIS M. E. Studies of the uricogenic effect of 2-substituted thiadiazoles in man. J Clin Invest. 1959 Jun;38(6):907–915. doi: 10.1172/JCI103873. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. KUPIECKI F. P., COON M. J. The enzymatic synthesis of beta-aminoisobutyrate, a product of valine metabolism, and of beta-alanine, a product of beta-hydroxypropionate metabolism. J Biol Chem. 1957 Dec;229(2):743–754. [PubMed] [Google Scholar]
  19. LIEBERMAN I., KORNBERG A., SIMMS E. S. Enzymatic synthesis of pyrimidine nucleotides; orotidine-5'-phosphate and uridine-5'-phosphate. J Biol Chem. 1955 Jul;215(1):403–451. [PubMed] [Google Scholar]
  20. MOORE E. C., LEPAGE G. A. In vivo sensitivity of normal and neoplastic mouse tissues to azaserine. Cancer Res. 1957 Sep;17(8):804–808. [PubMed] [Google Scholar]
  21. PASTERNAK C. A., HANDSCHUMACHER R. E. The biochemical activity of 6-azauridine: interference with pyrimidine metabolism in transplantable mouse tumors. J Biol Chem. 1959 Nov;234:2992–2997. [PubMed] [Google Scholar]
  22. RUBINI J. R., CRONKITE E. P., BOND V. P., FLIEDNER T. M. The metabolism and fate of tritiated thymidine in man. J Clin Invest. 1960 Jun;39:909–918. doi: 10.1172/JCI104111. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. SALSER J. S., HUTCHISON D. J., BALIS M. E. Studies on the mechanism of action of 6-mercaptopurine in cell-free preparations. J Biol Chem. 1960 Feb;235:429–432. [PubMed] [Google Scholar]
  24. SCHAR B., LOUSTALOT P., GROSS F. Demecolcin (Substanz F), ein neues, aus Colchicum autumnale isoliertes Alkaloid mit starker antimitotischer Wirkung. Klin Wochenschr. 1954 Jan 15;32(3-4):49–57. doi: 10.1007/BF01493523. [DOI] [PubMed] [Google Scholar]
  25. SEGAL S., BERMAN M., BLAIR A. The metabolism of variously C14-labeled glucose in man and an estimation of the extent of glucose metabolism by the hexose monophosphate pathway. J Clin Invest. 1961 Jul;40:1263–1279. doi: 10.1172/JCI104356. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. SMITH L. H., Jr, BAKER F. A. Pyrimidine metabolism in man. I. The biosynthesis of orotic acid. J Clin Invest. 1959 May;38(5):798–809. doi: 10.1172/JCI103862. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. SMITH L. H., Jr, SULLIVAN M. Feedback inhibition by fluorinated pyrimidines. Biochim Biophys Acta. 1960 Apr 22;39:554–557. doi: 10.1016/0006-3002(60)90218-3. [DOI] [PubMed] [Google Scholar]
  28. STONE J. E., POTTER V. R. Biochemical screening of pyrimidine antimetabolites. III. The testing of drugs against a system with a non-oxidative energy source. Cancer Res. 1957 Sep;17(8):800–803. [PubMed] [Google Scholar]
  29. Smith L. H., Sullivan M., Huguley C. M. PYRIMIDINE METABOLISM IN MAN. IV. THE ENZYMATIC DEFECT OF OROTIC ACIDURIA. J Clin Invest. 1961 Apr;40(4):656–664. doi: 10.1172/JCI104298. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. WELCH A. D., HANDSCHUMACHER R. E., FINCH S. C., JAFFE J. J., CARDOSO S. S., CALABRESI P. A synopsis of recent investigations of 6-azauridine (NSC-32074). Cancer Chemother Rep. 1960 Nov;9:39–46. [PubMed] [Google Scholar]
  31. WINZLER R. J. Differences in nucleic acid metabolism between normal and leukemic human leukocytes. Ann N Y Acad Sci. 1958 Oct 13;75(1):37–44. doi: 10.1111/j.1749-6632.1958.tb36849.x. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES