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. 1980 Jan;39(1):58–67. doi: 10.1128/aem.39.1.58-67.1980

Critical Reactions in Fluorobenzoic Acid Degradation by Pseudomonas sp. B13

A Schreiber 1, M Hellwig 1, E Dorn 1, W Reineke 1, H-J Knackmuss 1
PMCID: PMC291284  PMID: 16345496

Abstract

3-Chlorobenzoate-grown cells of Pseudomonas sp. B13 readily cometabolized monofluorobenzoates. A catabolic pathway for the isomeric fluorobenzoates is proposed on the basis of key metabolites isolated. Only 4-fluorobenzoate was utilized and totally degraded after a short period of adaptation. The isoenzymes for total degradation of chlorocatechols, being found during growth with 3-chlorobenzoate or 4-chlorophenol, were not induced in the presence of fluorobenzoates. Correspondingly, only the ordinary enzymes of the benzoate pathway were detected in 4-fluorobenzoate-grown cells. Ring cleavage of 3-fluorocatechol was recognized as a critical step in 3-fluorobenzoate degradation. 2-Fluoro-cis,cis-muconic acid was identified as a dead-end metabolite from 2- and 3-fluorobenzoate catabolism. During 2-fluorobenzoate cometabolism, fluoride is eliminated by the initial dioxygenation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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