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. 1971 Sep;50(9):1985–1991. doi: 10.1172/JCI106690

Amino acid oxidase of leukocytes in relation to H2O2-mediated bacterial killing

Marlene R Eckstein 1,2, Robert L Baehner 1,2, David G Nathan 1,2
PMCID: PMC292124  PMID: 4397948

Abstract

D-Amino acid oxidase and L-amino acid oxidase have been measured in sucrose homogenates of polymorphonuclear leukocytes (PMN) obtained from guinea pigs and humans. Subcellular distribution patterns and studies on latency indicate that these oxidases are soluble enzymes. Their hydrogen peroxide-generating capacity was verified. Chronic granulomatous disease PMN, which lack a respiratory burst and fail to generate H2O2 during phagocytosis and do not kill catalase positive bacteria, had peroxide-generating amino acid oxidase activity equal to that found in PMN homogenates from patients with bacterial infections. The precise metabolic and bactericidal role of amino acid oxidases in PMN remains uncertain.

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1991

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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