Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1971 Oct;50(10):2022–2032. doi: 10.1172/JCI106695

Relationship between plasma sodium concentration and vascular reactivity in man

Donald D Heistad 1,2, Francois M Abboud 1,2, Dennis R Ballard 1,2
PMCID: PMC292135  PMID: 4330003

Abstract

Experiments were done to study the effects of acute changes in plasma sodium concentration [Na] on vasoconstrictor responses to norepinephrine and to reflex sympathetic stimulation in man. [Na] in the venous return from the forearm of each of 21 normal subjects was reduced (to an average of 118 mEq/liter), increased (147 mEq/liter), and maintained within the normal range (140 mEq/liter) by means of infusions into the brachial artery of three solutions containing different [Na]. Mannitol or sucrose and disodium sulfate were substituted for sodium chloride to produce the desired changes in [Na] without changing blood osmolarity.

Blood flow to the forearm (plethysmograph) increased during infusion of the three solutions, but the increase in flow was not related to [Na]. Vasoconstrictor responses to injections of norepinephrine and angiotensin into the brachial artery were reduced at low [Na] and augmented at high [Na]. Reflex vasoconstriction, activated by lower body negative pressure, was similarly affected by changes in [Na]. In the isolated, perfused gracilis muscle of dog vasoconstrictor responses to norepinephrine and to nerve stimulation were attenuated, and the extraction of norepinephrine by this muscle was smaller when plasma [Na] was reduced.

Full text

PDF
2027

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abboud F. M., Hood J., Hodges R. E., Mayer H. E. Autonomic reflexes and vascular reactivity in experimental scurvy in man. J Clin Invest. 1970 Feb;49(2):298–307. doi: 10.1172/JCI106239. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Avakian O. V., Gillespie J. S. Uptake of noradrenaline by adrenergic nerves, smooth muscle and connective tissue in isolated perfused arteries and its correlation with the vasoconstrictor response. Br J Pharmacol Chemother. 1968 Jan;32(1):168–184. doi: 10.1111/j.1476-5381.1968.tb00441.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BIHLER I., CRANE R. K. Studies on the mechanism of intestinal absorption of sugars. V. The influence of several cations and anions on the active transport of sugars, in vitro, by various preparations of hamster small intestine. Biochim Biophys Acta. 1962 May 7;59:78–93. doi: 10.1016/0006-3002(62)90699-6. [DOI] [PubMed] [Google Scholar]
  4. BOHR D. F., BRODIE D. C., CHEU D. H. Effect of electrolytes on arterial muscle contraction. Circulation. 1958 Apr;17(4 Pt 2):746–749. doi: 10.1161/01.cir.17.4.746. [DOI] [PubMed] [Google Scholar]
  5. BOHR D. F. ELECTROLYTES AND SMOOTH MUSCLE CONTRACTION. Pharmacol Rev. 1964 Mar;16:85–127. [PubMed] [Google Scholar]
  6. Ballard D. R., Abboud F. M., Mayer H. E. Release of a humoral vasodilator substance during neurogenic vasodilatation. Am J Physiol. 1970 Nov;219(5):1451–1457. doi: 10.1152/ajplegacy.1970.219.5.1451. [DOI] [PubMed] [Google Scholar]
  7. Bogdanski D. F., Brodie B. B. Role of sodium and potassium ions in storage of norepinephrine by sympathetic nerve endings. Life Sci. 1966 Sep;5(17):1563–1569. doi: 10.1016/0024-3205(66)91025-3. [DOI] [PubMed] [Google Scholar]
  8. CSAKAY T. Z. A possible link between active transport of electrolytes and nonelectrolyes. Fed Proc. 1963 Jan-Feb;22:3–7. [PubMed] [Google Scholar]
  9. Friedman S. M., Friedman C. L. The ionic matrix of vasoconstriction. Circ Res. 1967 Jul;21(1 Suppl):147+–147+. [PubMed] [Google Scholar]
  10. HINKE J. A., WILSON M. L. Effects of electrolytes on contractility of artery segments in vitro. Am J Physiol. 1962 Dec;203:1161–1166. doi: 10.1152/ajplegacy.1962.203.6.1161. [DOI] [PubMed] [Google Scholar]
  11. Horst W. D., Kopin I. J., Ramey E. R. Influence of sodium and calcium on norepinephrine uptake by isolated perfused rat hearts. Am J Physiol. 1968 Oct;215(4):817–822. doi: 10.1152/ajplegacy.1968.215.4.817. [DOI] [PubMed] [Google Scholar]
  12. Lightman S. L., Iversen L. L. The role of uptake2 in the extraneuronal metabolism of catecholamines in the isolated rat heart. Br J Pharmacol. 1969 Nov;37(3):638–649. doi: 10.1111/j.1476-5381.1969.tb08502.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. MOLNAR J. I., SCOTT J. B., FROHLICH E. D., HADDY F. J. Local effects of various anions and H ions on dog limb and coronary vascular resistances. Am J Physiol. 1962 Jul;203:125–132. doi: 10.1152/ajplegacy.1962.203.1.125. [DOI] [PubMed] [Google Scholar]
  14. Overbeck H. W., Grega G. J. Response of the limb vascular bed in man to intrabrachial arterial infusions of hypertonic dextrose or hypertonic sodium chloride solutions. Circ Res. 1970 Jun;26(6):717–731. doi: 10.1161/01.res.26.6.717. [DOI] [PubMed] [Google Scholar]
  15. RAAB W., HUMPHREYS R. J., LEPESCHKIN E. Potentiation of pressor effects of nor-epinephrine and epinephrine in man by desoxycorticosterone acetate. J Clin Invest. 1950 Oct;29(10):1397–1404. doi: 10.1172/JCI102377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Schmid P. G., Eckstein J. W., Abboud F. M. Comparison of effects of deoxycorticosterone and dexamethasone on cardiovascular responses to norepinephrine. J Clin Invest. 1967 Apr;46(4):590–598. doi: 10.1172/JCI105560. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. TOBIAN L., FOX A. The effect of norepinephrine on the electrolyte composition of arterial smooth muscle. J Clin Invest. 1956 Mar;35(3):297–301. doi: 10.1172/JCI103277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. TOBIAN L. Interrelationship of electrolytes, juxtaglomerular cells and hypertension. Physiol Rev. 1960 Apr;40:280–312. doi: 10.1152/physrev.1960.40.2.280. [DOI] [PubMed] [Google Scholar]
  19. Von Euler U. S. Some factors affecting catecholamine uptake, storage, and release in adrenergic nerve granules. Circ Res. 1967 Dec;21(6 Suppl):5–11. [PubMed] [Google Scholar]
  20. YAMABAYASHI H., HAMILTON W. F. Effect of sodium ion on contractility of the dog's aortic strip in response to catecholamines. Am J Physiol. 1959 Nov;197:993–996. doi: 10.1152/ajplegacy.1959.197.5.993. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES