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. 1971 Nov;50(11):2368–2375. doi: 10.1172/JCI106735

Immunoglobulins on the surface of lymphocytes

IV. Distribution in hypogammaglobulinemia, cellular immune deficiency, and chronic lymphatic leukemia

Howard M Grey 1,2, Enrique Rabellino 1,2, Bernard Pirofsky 1,2
PMCID: PMC292179  PMID: 4999540

Abstract

The distribution of peripheral blood lymphocytes that contain surface Ig has been studied by means of immunofluorescence in humans. Normal individuals, individuals with sex-linked and acquired agammaglobulinemia, selective IgA deficiency, cellular immune deficiencies, and individuals with chronic lymphatic leukemia (CLL) were studied. Approximately 28% of the peripheral blood lymphocytes from normal individuals contained surface Ig. On an average 15% contained IgG, 6%, IgA, and 8%, IgM; and the kappa: lambda ratio was 2:1. Lymphocytes from patients with CLL appeared to be “monoclonal” in that the cells from a given individual had a single Ig associated with them (e.g., kappa IgM). In three-quarters of the cases the H chain class was IgM; in the remaining one-quarter no H chain could be detected on the cell surface. The L chain class was kappa in 12 cases and lambda in 8. Four patients with sex-linked agammaglobulinemia and one with “acquired” agammaglobulinemia had markedly decreased numbers of cells with surface Ig (0-4%). In contrast, the three patients with selective IgA deficiency and no detectable serum IgA contained normal numbers of cells (6-8%) with surface IgA. Five patients with cellular deficiency states, including two with Wiskott-Aldrich syndrome, contained a normal or low percentage of cells with surface Ig.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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