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. 1965 Apr;44(4):629–642. doi: 10.1172/JCI105176

The Mechanism of Action of Adenine in Red Cell Preservation*

Yoshiki Sugita 1,2,, Ernest R Simon 1,2,
PMCID: PMC292538  PMID: 14278179

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARTLETT G. R., BARNET H. N. Changes in the phosphate compounds of the human red blood cell during blood bank storage. J Clin Invest. 1960 Jan;39:56–61. doi: 10.1172/JCI104026. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BARTLETT G. R. Human red cell glycolytic intermediates. J Biol Chem. 1959 Mar;234(3):449–458. [PubMed] [Google Scholar]
  3. BARTLETT G. R., SHAFER A. W. Phosphorylated carbohydrate intermediates of the human erythrocyte during storage in acid citrate dextrose. II. Effect of the addition of inosine late in storage. J Clin Invest. 1961 Jul;40:1185–1193. doi: 10.1172/JCI104348. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BEUTLER E., DURON O. EFFECT OF PH ON PRESERVATION OF RED CELL ATP. Transfusion. 1965 Jan-Feb;5:17–24. doi: 10.1111/j.1537-2995.1965.tb01131.x. [DOI] [PubMed] [Google Scholar]
  5. BISHOP C. Changes in the nucleotides of stored or incubated human blood. Transfusion. 1961 Nov-Dec;1:349–354. doi: 10.1111/j.1537-2995.1961.tb00073.x. [DOI] [PubMed] [Google Scholar]
  6. BISHOP C., RANKINE D. M., TALBOTT J. H. The nucleotides in normal human blood. J Biol Chem. 1959 May;234(5):1233–1237. [PubMed] [Google Scholar]
  7. BISHOP C. SOME IN VITRO EFFECTS OF ADENINE ADDED TO STORED BLOOD. Transfusion. 1964 Jul-Aug;4:265–270. doi: 10.1111/j.1537-2995.1964.tb02870.x. [DOI] [PubMed] [Google Scholar]
  8. BOWMAN H. S. RED CELL PRESERVATION IN CITRATE-PHOSPHATE-DEXTROSE AND IN ACID-CITRATE-DEXTROSE: COMPARISON OF ERYTHROCYTE VIABILITY AFTER 28 DAYS REFRIGERATED STORAGE. Transfusion. 1963 Sep-Oct;3:364–367. doi: 10.1111/j.1537-2995.1963.tb04658.x. [DOI] [PubMed] [Google Scholar]
  9. CLARKE D. A., DAVOLL J., PHILIPS F. S., BROWN G. B. Enzymatic deamination and vasodepressor effects of adenosine analogs. J Pharmacol Exp Ther. 1952 Nov;106(3):291–302. [PubMed] [Google Scholar]
  10. CROUCH S. K., BISHOP C. THE MAINTENANCE OF ATP IN STORED BLOOD BY ADENOSINE AND INOSINE. Transfusion. 1963 Sep-Oct;3:349–355. doi: 10.1111/j.1537-2995.1963.tb04655.x. [DOI] [PubMed] [Google Scholar]
  11. Conway E. J., Cooke R. The deaminases of adenosine and adenylic acid in blood and tissues. Biochem J. 1939 Apr;33(4):479–492. doi: 10.1042/bj0330479. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. DENSTEDT O. F., RUBINSTEIN D. The metabolism of the erythrocyte. XIV. Metabolism of nucleosides by the erythrocyte. Can J Biochem Physiol. 1956 Sep;34(5):927–937. [PubMed] [Google Scholar]
  13. DEVERDIER C. H., GARBY L., HJELM M., HOEGMAN C. ADENINE IN BLOOD PRESERVATION: POSTTRANSFUSION VIABILITY AND BIOCHEMICAL CHANGES. Transfusion. 1964 Sep-Oct;4:331–338. doi: 10.1111/j.1537-2995.1964.tb02883.x. [DOI] [PubMed] [Google Scholar]
  14. DEVERDIER C. H., HOEGMAN C., GARBY L., KILLANDER J. STORAGE OF HUMAN RED BLOOD CELLS. II. THE EFFECT OF PH AND OF THE ADDITION OF ADENINE. Acta Physiol Scand. 1964 Jan-Feb;60:141–149. doi: 10.1111/j.1748-1716.1964.tb02877.x. [DOI] [PubMed] [Google Scholar]
  15. FERBER E., FISCHER H. [Studies on improved cell preservation. III. The effect of purine nucleosides and steroids on the mechanical resistance of fresh and stored erythrocytes]. Klin Wochenschr. 1963 May 1;41:427–433. doi: 10.1007/BF01483306. [DOI] [PubMed] [Google Scholar]
  16. GABRIO B. W., FINCH C. A., HUENNEKENS F. M. Erythrocyte preservation: a topic in molecular biochemistry. Blood. 1956 Feb;11(2):103–113. [PubMed] [Google Scholar]
  17. GABRIO B. W., HUENNEKENS F. M., NURK E. Erythrocyte metabolism. I. Purine nucleoside phosphorylase. J Biol Chem. 1956 Aug;221(2):971–981. [PubMed] [Google Scholar]
  18. GABRIO B. W., HUENNEKENS F. M. The role of nucleoside phosphorylase in erythrocyte preservation. Biochim Biophys Acta. 1955 Dec;18(4):585–586. doi: 10.1016/0006-3002(55)90163-3. [DOI] [PubMed] [Google Scholar]
  19. GIBSON J. G., 2nd, REES S. B., McMANUS T. J., SCHEITLIN W. A. A cltrate-phosphatedextrose solution for the preservation of human blood. Am J Clin Pathol. 1957 Dec;28(6):569–578. doi: 10.1093/ajcp/28.6.569. [DOI] [PubMed] [Google Scholar]
  20. HASHIMOTO T., ISHI Y., TATIBANA M., YOSHIKAWA H. The presence of adenylyl 2,3-diphosphoglyceric acid in human and rabbit blood. J Biochem. 1961 Nov;50:471–472. doi: 10.1093/oxfordjournals.jbchem.a127477. [DOI] [PubMed] [Google Scholar]
  21. HASHIMOTO T., YOSHIKAWA H. Further studies on adenylyl 2, 3-diphosphoglyceric acid. J Biochem. 1963 Mar;53:219–226. doi: 10.1093/oxfordjournals.jbchem.a127682. [DOI] [PubMed] [Google Scholar]
  22. HEPPEL L. A., HILMORE R. J. Purification and properties of 5-nucleotidase. J Biol Chem. 1951 Feb;188(2):665–676. [PubMed] [Google Scholar]
  23. HURLBERT R. B., SCHMITZ H., BRUMM A. F., POTTER V. R. Nucleotide metabolism. II. Chromatographic separation of acid-soluble nucleotides. J Biol Chem. 1954 Jul;209(1):23–39. [PubMed] [Google Scholar]
  24. JORGENSEN S., OVERGAARD-HANSEN K., PRAETORIUS E. Rephosphorylation produced by inosine and adenosine of adenosine monophosphate and adenosine diphosphate in human erythrocytes. Nature. 1957 Jan 19;179(4551):152–153. doi: 10.1038/179152a0. [DOI] [PubMed] [Google Scholar]
  25. KASHKET S., DENSTEDT O. F. The metabolism of the erythrocyte. XV. Adenylate kinase of the erythrocyte. Can J Biochem Physiol. 1958 Oct;36(10):1057–1064. [PubMed] [Google Scholar]
  26. KASHKET S., RUBINSTEIN D., DENSTEDT O. F. Studies on the preservation of blood. V. The influence of the hydrogen ion concentration on certain changes in blood during storage. Can J Biochem Physiol. 1957 Oct;35(10):827–834. [PubMed] [Google Scholar]
  27. KLEINE N., SCHMITT H. [New viewpoints and data on the storage of preserved blood]. Blut. 1962 May;8:145–157. doi: 10.1007/BF01631168. [DOI] [PubMed] [Google Scholar]
  28. KORNBERG A., LIEBERMAN I., SIMMS E. S. Enzymatic synthesis of purine nucleotides. J Biol Chem. 1955 Jul;215(1):417–427. [PubMed] [Google Scholar]
  29. KORN E. D., BUCHANAN J. M. Biosynthesis of the purines. VI. Purification of liver nucleoside phosphorylase and demonstration of nucleoside synthesis from 4-amino-5-imidazolecarboxamide, adenine, and 2, 6-diaminopurine. J Biol Chem. 1955 Nov;217(1):183–191. [PubMed] [Google Scholar]
  30. KOZEK W., BISHOP C. COMPARISON OF BLOOD STORED IN ACD AND IN A SOLUTION CONTAINING HEPARIN, PHOSPHATE, GLUCOSE AND ADENINE. Transfusion. 1964 Jul-Aug;4:271–276. doi: 10.1111/j.1537-2995.1964.tb02871.x. [DOI] [PubMed] [Google Scholar]
  31. LOWY B. A., WILLIAMS M. K., LONDON I. M. Enzymatic deficiencies of purine nucleotide synthesis in the human erythrocyte. J Biol Chem. 1962 May;237:1622–1625. [PubMed] [Google Scholar]
  32. MILLS G. C., SUMMERS L. B. The metabolism of nucleotides and other phosphate esters in erythrocytes during in vitro incubation at 37 degrees. Arch Biochem Biophys. 1959 Sep;84:7–14. doi: 10.1016/0003-9861(59)90548-x. [DOI] [PubMed] [Google Scholar]
  33. MOLLISON P. L., ROBINSON M. A. Observations on the effects of purine nucleosides on red-cell preservation. Br J Haematol. 1959 Oct;5:331–343. doi: 10.1111/j.1365-2141.1959.tb04043.x. [DOI] [PubMed] [Google Scholar]
  34. NAKAO K., WADA T., KAMIYAMA T., NAKAO M., NAGANO K. A direct relationship between adenosine triphosphate-level and in vivo viability of erythrocytes. Nature. 1962 Jun 2;194:877–878. doi: 10.1038/194877a0. [DOI] [PubMed] [Google Scholar]
  35. NAKAO M., MOTEGI T., NAKAO T., YAMAZOE S., YOSHIKAWA H. A positive feedback mechanism of adenosine triphosphate synthesis in erythrocytes. Nature. 1961 Jul 15;191:283–284. doi: 10.1038/191283a0. [DOI] [PubMed] [Google Scholar]
  36. NAKAO M., NAKAO T., TATIBANA M., YOSHIKAWA H., ABE T. Effect of inosine and adenine on adenosine triphosphate regeneration and shape transformation in long-stored erythrocyts. Biochim Biophys Acta. 1959 Apr;32:564–565. doi: 10.1016/0006-3002(59)90640-7. [DOI] [PubMed] [Google Scholar]
  37. OVERGAARD-HANSEN K. Rejuvenation of adenosine triphosphate in human erythrocytes by purine nucleosides. Acta Pharmacol Toxicol (Copenh) 1957;14(1):67–76. doi: 10.1111/j.1600-0773.1957.tb01143.x. [DOI] [PubMed] [Google Scholar]
  38. PREISS J., HANDLER P. Enzymatic synthesis of nicotinamide mononucleotide. J Biol Chem. 1957 Apr;225(2):759–770. [PubMed] [Google Scholar]
  39. RAPOPORT S., DIETZE F., SAUER G. QUANTITATIVE ASPEKTE DES PHOSPHOGLYCERATZYKLUS IN ROTEN BLUTZELLEN. Acta Biol Med Ger. 1964;13:693–702. [PubMed] [Google Scholar]
  40. RUBINSTEIN D., KASHKET S., DENSTEDT O. F. Studies on the preservation of blood. IV. The influence of adenosine on the glycolytic activity of the erythrocyte during storage at 4 degrees C. Can J Biochem Physiol. 1956 Jan;34(1):61–74. [PubMed] [Google Scholar]
  41. RUBINSTEIN D., KASHKET S., DENSTEDT O. F. Studies on the preservation of blood. VI. The influence of adenosine and inosine on the metabolism of the erythrocyte. Can J Biochem Physiol. 1958 Dec;36(12):1269–1276. [PubMed] [Google Scholar]
  42. SANDBERG A. A., LEE G. R., CARTWRIGHT G. E., WINTROBE M. M. Purine nucleoside phosphorylase activity of blood. I. Erythrocytes. J Clin Invest. 1955 Dec;34(12):1823–1829. doi: 10.1172/JCI103238. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. SHAFER A. W., BARTLETT G. R. Phosphorylated carbohydrate intermediates of the human erythrocyte during storage in acid citrate dextrose. III. Effect of incubation at 37 degrees C. with inosine, inosine plus adenine, and adenosine after storage for 6, 10, 14 and 18 weeks. J Clin Invest. 1962 Apr;41:690–695. doi: 10.1172/JCI104526. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. SHAFER A. W., TROMBOLD J. S. PHOSPHORYLATED CARBOHYDRATE INTERMEDIATES OF THE HUMAN ERYTHROCYTE DURING STORAGE IN ACID CITRATE DEXTROSE. IV. EFFECT OF ADDITION OF ADENINE, INOSINE, INOSINE-ADENINE AND ADENOSINE AT THE BEGINNING OF STORAGE. Transfusion. 1964 Mar-Apr;4:120–123. doi: 10.1111/j.1537-2995.1964.tb02842.x. [DOI] [PubMed] [Google Scholar]
  45. SIMON E. R., CHAPMAN R. G., FINCH C. A. Adenine in red cell preservation. J Clin Invest. 1962 Feb;41:351–359. doi: 10.1172/JCI104489. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. SIMON E. R. Red cell preservation: further studies with adenine. Blood. 1962 Oct;20:485–491. [PubMed] [Google Scholar]
  47. TSUBOI K. K., HUDSON P. B. Enzymes of the human erythrocyte. I. Purine nucleoside phosphorylase; isolation procedure. J Biol Chem. 1957 Feb;224(2):879–887. [PubMed] [Google Scholar]

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