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. 1965 Sep;44(9):1505–1513. doi: 10.1172/JCI105257

Aldosterone Secretion Rate in Congenital Adrenal Hyperplasia. A Discussion of the Theories on the Pathogenesis of the Salt-losing Form of the Syndrome*

Avinoam Kowarski 1,2,†, Jordan W Finkelstein 1,2,†, John S Spaulding 1,2,†, Gerald H Holman 1,2, Claude J Migeon 1,2,‡
PMCID: PMC292632  PMID: 14332163

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARNETT H. L., McNAMARA H. Electrolyte balances in a male infant with adrenocortical insufficiency and virilism; the effect of desoxycorticosterone acetate and salt therapy with special reference to potassium. J Clin Invest. 1949 Nov;28(6 Pt 2):1498–1506. doi: 10.1172/JCI102215. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BARTTER F. C., ALBRIGHT F., FORBES A. P., LEAF A., DEMPSEY E., CARROLL E. The effects of adrenocorticotropic hormone and cortisone in the adrenogenital syndrome associated with congenital adrenal hyperplasia: an attempt to explain and correct its disordered hormonal pattern. J Clin Invest. 1951 Mar;30(3):237–251. doi: 10.1172/JCI102438. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BLIZZARD R. M., LIDDLE G. W., MIGEON C. J., WILKINS L. Aldosterone excretion in virilizing adrenal hyperplasia. J Clin Invest. 1959 Aug;38(8):1442–1451. doi: 10.1172/JCI103921. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BONGIOVANNI A. M. In vitro hydroxylation of steroids by whole adrenal homogenates of beef, normal man, and patients with the adrenogenital syndrome. J Clin Invest. 1958 Oct;37(10):1342–1347. doi: 10.1172/JCI103723. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. CRIGLER J. F., Jr, SILVERMAN S. H., WILKINS L. Further studies on the treatment of congenital adrenal hyperplasia with cortisone. IV. Effect of cortisone and compound B in infants with disturbed electrolyte metabolism. Pediatrics. 1952 Oct;10(4):397–413. [PubMed] [Google Scholar]
  6. EBERLEIN W. R., BONGIOVANNI A. M. Partial characterization of urinary adrenocortical steroids in adrenal hyperplasia. J Clin Invest. 1955 Aug;34(8):1337–1343. doi: 10.1172/JCI103181. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. EBERLEIN W. R. The salt-losing form of congenital adrenal hyperplasia. Pediatrics. 1958 Apr;21(4):667–672. [PubMed] [Google Scholar]
  8. FINKELSTEIN J. W., KOWARSKI A., SPAULDING J. S., MIGEON C. J. EFFECT OF VARIOUS PREPARATIONS OF HUMAN GROWTH HORMONE ON ALDOSTERONE SECRETION RATE OF HYPOPITUITARY DWARFS. Am J Med. 1965 Apr;38:517–521. doi: 10.1016/0002-9343(65)90129-4. [DOI] [PubMed] [Google Scholar]
  9. FUKUSHIMA D. K., GALLAGHER T. F. Steroid isolation studies in congenital adrenal hyperplasia. J Biol Chem. 1957 Nov;229(1):85–92. [PubMed] [Google Scholar]
  10. JACOBS D. R., VAN DER POLL J., GABRILOVE J. L., SOFFER L. J. 17alpha-Hydroxyprogesterone--a salt-losing steroid: relation to congenital adrenal hyperplasia. J Clin Endocrinol Metab. 1961 Aug;21:909–922. doi: 10.1210/jcem-21-8-909. [DOI] [PubMed] [Google Scholar]
  11. JAILER J. H., LOUCHART J., CAHILL G. F. Adrenal virilism. II. Metabolic studies. J Clin Invest. 1952 Oct;31(10):880–884. doi: 10.1172/JCI102675. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. KENNY F. M., MALVAUX P., MIGEON C. J. Cortisol production rate in newborn babies, older infants, and children. Pediatrics. 1963 Mar;31:360–373. [PubMed] [Google Scholar]
  13. KLEIN R. Evidence for and against the existence of a salt-losing hormone. J Pediatr. 1960 Sep;57:452–460. doi: 10.1016/s0022-3476(60)80253-3. [DOI] [PubMed] [Google Scholar]
  14. KLEIN R., TAYLOR P., PAPADATOS C., LARON Z., KEELE D., FORTUNATO J., BYERS C., BILLINGS C. Sodium losing material in human urine. Proc Soc Exp Biol Med. 1958 Aug-Sep;98(4):863–866. doi: 10.3181/00379727-98-24210. [DOI] [PubMed] [Google Scholar]
  15. KLIMAN B., PETERSON R. E. Double isotope derivative assay of aldosterone in biological extracts. J Biol Chem. 1960 Jun;235:1639–1648. [PubMed] [Google Scholar]
  16. LANDAU R. L., BERGENSTAL D. M., LUGIBIHL K., KASCHT M. E. The metabolic effects of progesterone in man. J Clin Endocrinol Metab. 1955 Oct;15(10):1194–1215. doi: 10.1210/jcem-15-10-1194. [DOI] [PubMed] [Google Scholar]
  17. LANDAU R. L., LUGIBIHL K., BERGENSTAL D. M., DIMICK D. F. The metabolic effects of progesterone in man: dose response relationships. J Lab Clin Med. 1957 Oct;50(4):613–620. [PubMed] [Google Scholar]
  18. LANDAU R. L., LUGIBIHL K. Inhibition of the sodium-retaining influence of aldosterone by progesterone. J Clin Endocrinol Metab. 1958 Nov;18(11):1237–1245. doi: 10.1210/jcem-18-11-1237. [DOI] [PubMed] [Google Scholar]
  19. MATTOX V. R., HAYLES A. B., SALASSA R. M., DION F. R. URINARY STEROID PATTERNS AND LOSS OF SALT IN CONGENITAL ADRENAL HYPERPLASIA. J Clin Endocrinol Metab. 1964 Jun;24:517–527. doi: 10.1210/jcem-24-6-517. [DOI] [PubMed] [Google Scholar]
  20. MIGEON C. J., GREEN O. C., ECKERT J. P. STUDY OF ADRENOCORTICAL FUNCTION IN OBESITY. Metabolism. 1963 Aug;12:718–739. [PubMed] [Google Scholar]
  21. PRADER A., SPAHR A., NEHER R. Erhöhte Aldosteronausscheidung beim kongenitalen adrenogenitalen Syndrom; ein Beitrag zur Pathogenese des Syndroms. Schweiz Med Wochenschr. 1955 Nov 5;85(45):1085–1088. [PubMed] [Google Scholar]
  22. WILKINS L., CRIGLER J. F., Jr, SILVERMAN S. H., GARDNER L. I., MIGEON C. J. Further studies on the treatment of congenital adrenal hyperplasia with cortisone. II. The effects of cortisone on sexual and somatic development, with an hypothesis concerning the mechanism of feminization. J Clin Endocrinol Metab. 1952 Mar;12(3):277–295. doi: 10.1210/jcem-12-3-277. [DOI] [PubMed] [Google Scholar]
  23. de GRAEFF, MOOLENAAR A. J. Effect of cortisone on the excretion of aldosterone in virilising adrenal hyperplasia. Lancet. 1960 Apr 16;1(7129):854–855. doi: 10.1016/s0140-6736(60)90735-2. [DOI] [PubMed] [Google Scholar]

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