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. 1967 Oct;46(10):1589–1595. doi: 10.1172/JCI105650

Brain Metabolism during Fasting*

O E Owen 1,2, A P Morgan 1,2, H G Kemp 1,2, J M Sullivan 1,2, M G Herrera 1,2, G F Cahill Jr 1,2,‡
PMCID: PMC292907  PMID: 6061736

Abstract

Catheterization of cerebral vessels in three obese patients undergoing 5-6 wk of starvation demonstrated that β-hydroxybutyrate and acetoacetate replaced glucose as the predominant fuel for brain metabolism. A strikingly low respiratory quotient was also observed, suggesting a carboxylation mechanism as a means of disposing of some of the carbon of the consumed substrates.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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