Skip to main content
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1959 Jul;38(7):1086–1095. doi: 10.1172/JCI103885

THE MECHANISM OF CLOT DISSOLUTION BY PLASMIN*

Norma Alkjaersig 1, Anthony P Fletcher 1, Sol Sherry 1
PMCID: PMC293256  PMID: 13664784

Full text

PDF
1087

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALKJAERSIG N., FLETCHER A. P., SHERRY S. The activation of human plasminogen. I. Spontaneous activation in glycerol. J Biol Chem. 1958 Jul;233(1):81–85. [PubMed] [Google Scholar]
  2. ALKJAERSIG N., FLETCHER A. P., SHERRY S. The activation of human plasminogen. II. A kinetic study of activation with trypsin, urokinase, and streptokinase. J Biol Chem. 1958 Jul;233(1):86–90. [PubMed] [Google Scholar]
  3. ALKJAERSIG N., FLETCHER A. P., SHERRY S. xi-Aminocaproic acid: an inhibitor of plasminogen activation. J Biol Chem. 1959 Apr;234(4):832–837. [PubMed] [Google Scholar]
  4. ASTRUP T. Fibrinolysis in the organism. Blood. 1956 Sep;11(9):781–806. [PubMed] [Google Scholar]
  5. ASTRUP T. The activation of a proteolytic enzyme in blood by animal tissue. Biochem J. 1951 Nov;50(1):5–11. doi: 10.1042/bj0500005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. FLETCHER A. P., ALKJAERSIG N., SHERRY S. The maintenance of a sustained thrombolytic state in man. I. Induction and effects. J Clin Invest. 1959 Jul;38(7):1096–1110. doi: 10.1172/JCI103886. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. JOHNSON A. J., TILLETT W. S. The lysis in rabbits of intravascular blood clots by the streptococcal fibrinolytic system (streptokinase). J Exp Med. 1952 May 1;95(5):449–464. doi: 10.1084/jem.95.5.449. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. KJELDGAARD N. O., PLOUG J. Urokinase an activator of plasminogen from human urine. II. Mechanism of plasminogen activation. Biochim Biophys Acta. 1957 May;24(2):283–289. doi: 10.1016/0006-3002(57)90195-6. [DOI] [PubMed] [Google Scholar]
  9. KLINE D. L., FISHMAN J. B. Plasmin, the humoral protease. Ann N Y Acad Sci. 1957 Aug 30;68(1):25–37. doi: 10.1111/j.1749-6632.1957.tb42609.x. [DOI] [PubMed] [Google Scholar]
  10. LASSEN M. Heat denaturation of plasminogen in the fibrin plate method. Acta Physiol Scand. 1953 Feb 28;27(4):371–376. doi: 10.1111/j.1748-1716.1953.tb00951.x. [DOI] [PubMed] [Google Scholar]
  11. MULLERTZ S. Fibrinolytic and Fibrino genolytic methods for estimating plasmin and trypsin. Acta Physiol Scand. 1952 Sep 10;26(2-3):174–182. doi: 10.1111/j.1748-1716.1952.tb00899.x. [DOI] [PubMed] [Google Scholar]
  12. MULLERTZ S. Formation and properties of the activator of plasminogen and of human and bovine plasmin. Biochem J. 1955 Nov;61(3):424–434. doi: 10.1042/bj0610424. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. MULLERTZ S., LASSEN M. An activator system in blood indispensable for formation of plasmin by streptokinase. Proc Soc Exp Biol Med. 1953 Feb;82(2):264–268. doi: 10.3181/00379727-82-20087. [DOI] [PubMed] [Google Scholar]
  14. RATNOFF O. D., MENZIE C. A new method for the determination of fibrinogen in small samples of plasma. J Lab Clin Med. 1951 Feb;37(2):316–320. [PubMed] [Google Scholar]
  15. REMMERT L. F., COHEN P. P. Partial purification and properties of a proteolytic enzyme of human serum. J Biol Chem. 1949 Nov;181(1):431–448. [PubMed] [Google Scholar]
  16. SHERRY S., FLETCHER A. P., ALKJAERSIG N. Fibrinolysis and fibrinolytic activity in man. Physiol Rev. 1959 Apr;39(2):343–382. doi: 10.1152/physrev.1959.39.2.343. [DOI] [PubMed] [Google Scholar]
  17. SHERRY S., LINDEMEYER R. I., FLETCHER A. P., ALKJAERSIG N. Studies on enhanced fibrinolytic activity in man. J Clin Invest. 1959 May;38(5):810–822. doi: 10.1172/JCI103863. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. SHERRY S., TITCHENER A., GOTTESMAN L., WASSERMAN P., TROLL W. The enzymatic dissolution of experimental arterial thrombi in the dog by trypsin, chymotrypsin and plasminogen activators. J Clin Invest. 1954 Oct;33(10):1303–1313. doi: 10.1172/JCI103006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. SHERRY S. The fibrinolytic activity of streptokinase activated human plasmin. J Clin Invest. 1954 Jul;33(7):1054–1063. doi: 10.1172/JCI102973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. TROLL W., SHERRY S. The activation of human plasminogen by streptokinase. J Biol Chem. 1955 Apr;213(2):881–891. [PubMed] [Google Scholar]
  21. TROLL W., SHERRY S., WACHMAN J. The action of plasmin on synthetic substrates. J Biol Chem. 1954 May;208(1):85–93. [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES