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. 1960 Mar;39(3):447–454. doi: 10.1172/JCI104057

SUPPRESSION OF URIC ACID SYNTHESIS IN THE GOUTY HUMAN BY THE USE OF 6-DIAZO-5-OXO-L-NORLEUCINE*

Arthur I Grayzel 1, J E Seegmiller 1, Ethel Love 1
PMCID: PMC293323  PMID: 13829149

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENEDICT J. D., FORSHAM P. H., STETTEN D., Jr The metabolism of uric acid in the normal and gouty human studied with the aid of isotopic uric acid. J Biol Chem. 1949 Nov;181(1):183–193. [PubMed] [Google Scholar]
  2. BENEDICT J. D., ROCHE M., YU T. F., BIEN E. J., GUTMAN A. B., STETTEN D., Jr Incorporation of glycine nitrogen into uric acid in normal and gouty man. Metabolism. 1952 Jan;1(1):3–12. [PubMed] [Google Scholar]
  3. BIEN E. J., YU T. F., BENEDICT J. D., GUTMAN A. B., STETTEN D., Jr The relation of dietary nitrogen consumption to the rate of uric acid synthesis in normal and gouty man. J Clin Invest. 1953 Aug;32(8):778–780. doi: 10.1172/JCI102792. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. ELLISON R. R., KARNOFSKY D. A., STERNBERG S. S., MURPHY M. L., BURCHENAL J. H. Clinical trials of O-diazoacetyl-L-serine (azaserine) in neoplastic disease. Cancer. 1954 Jul;7(4):801–814. doi: 10.1002/1097-0142(195407)7:4<801::aid-cncr2820070419>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  5. GUTMAN A. B., YU T. F., BLACK H., YALOW R. S., BERSON S. A. Incorporation of glycine-1-C14, glycine-2-C14 and glycine-N15 into uric acid in normal and gouty subjects. Am J Med. 1958 Dec;25(6):917–932. doi: 10.1016/0002-9343(58)90063-9. [DOI] [PubMed] [Google Scholar]
  6. KRAKOFF I. H., BALIS M. E. Studies of the uricogenic effect of 2-substituted thiadiazoles in man. J Clin Invest. 1959 Jun;38(6):907–915. doi: 10.1172/JCI103873. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. KRAKOFF I. H., KARNOFSKY D. A. Inhibition of uric acid biosynthesis in birds by o-diazoacetyl-L-serine (azaserine) and 6-diazo-5-oxo-L-norleucine (DON). Am J Physiol. 1958 Oct;195(1):244–250. doi: 10.1152/ajplegacy.1958.195.1.244. [DOI] [PubMed] [Google Scholar]
  8. LEVENBERG B., MELNICK I., BUCHANAN J. M. Biosynthesis of the purines. XV. The effect of aza-L-serine and 6-diazo-5-oxo-L-norleucine on inosinic acid biosynthesis de novo. J Biol Chem. 1957 Mar;225(1):163–176. [PubMed] [Google Scholar]
  9. LIDDLE L., SEEGMILLER J. E., LASTER L. The enzymatic spectrophotometric method for determination of uric acid. J Lab Clin Med. 1959 Dec;54:903–913. [PubMed] [Google Scholar]
  10. MAGILL G. B., MYERS W. P., REILLY H. C., PUTNAM R. C., MAGILL J. W., SYKES M. P., ESCHER G. C., KARNOFSKY D. A., BURCHENAL J. H. Pharmacological and initial therapeutic observations on 6-diazo-5-oxo-1-norleucine (DON) in human neoplastic disease. Cancer. 1957 Nov-Dec;10(6):1138–1150. doi: 10.1002/1097-0142(195711/12)10:6<1138::aid-cncr2820100608>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]
  11. PARDEE A. B., YATES R. A. Control of pyrimidine biosynthesis in Escherichia coli by a feed-back mechanism. J Biol Chem. 1956 Aug;221(2):757–770. [PubMed] [Google Scholar]
  12. SEEGMILLER J. E., GRAYZEL A. I., LIDDLE L. Excessive uric acid production in the human induced by 2-ethylamino-1,3,4-thiadiazole. Nature. 1959 May 23;183(4673):1463–1464. doi: 10.1038/1831463a0. [DOI] [PubMed] [Google Scholar]
  13. SEEGMILLER J. E., LASTER L., LIDDLE L. V. Failure to detect consistent overincorporation of glycine-1-C14 into uric acid in primary gout. Metabolism. 1958 Jul;7(4 Pt 1):376–377. [PubMed] [Google Scholar]
  14. SEEGMILLER J. E., LASTER L., STETTEN D., Jr Incorporation of 4-amino-5-imidazolecarboxamide-4-C13 into uric acid in the normal human. J Biol Chem. 1955 Oct;216(2):653–662. [PubMed] [Google Scholar]
  15. SOLOWAY S., STETTEN D., Jr The metabolism of choline and its conversion to glycine in the rat. J Biol Chem. 1953 Sep;204(1):207–214. [PubMed] [Google Scholar]
  16. TAUSSKY H. H. A microcolorimetric determination of creatine in urine by the Jaffe reaction. J Biol Chem. 1954 Jun;208(2):853–861. [PubMed] [Google Scholar]
  17. WYNGAARDEN J. B., ASHTON D. M. The regulation of activity of phosphoribosyl-pyrophosphate amidotransferase by purine ribonacleotides: a potential feedback control of purine biosyntoesis. J Biol Chem. 1959 Jun;234(6):1492–1496. [PubMed] [Google Scholar]
  18. WYNGAARDEN J. B. Overproduction of uric acid as the cause of hyperuricemia in primary gout. J Clin Invest. 1957 Oct;36(10):1508–1515. doi: 10.1172/JCI103547. [DOI] [PMC free article] [PubMed] [Google Scholar]

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