Abstract
1 The effect of N-desmethyldiazepam (nordiazepam, 5 and 10 mg) and potassium clorazepate (15 mg, a precursor of nordiazepam) on sleep was studied in six healthy adult males. Electroencephalography (EEG) was used for sleep measures, and analogue scales were used for subjective assessments of well-being and sleep quality. 2 Effects on total sleep time were limited to the night of ingestion. There were increases with nordiazepam (5 and 10 mg) (P = 0.05) and 0.001 respectively), and with clorazepate (15 mg) (P = 0.01). Sleep onset latencies were shortened, particularly with nordiazepam, and awakening to stage 0 activity was reduced, by both drugs. The latency to stage 3 was reduced by nordiazepam (5 and 10 mg) (P = 0.05). 3 There were no effects of nordiazepam (5 mg) on the duration (min) of sleep stages. Nordiazepam (10 mg) and clorazepate (15 mg) reduced the duration of stage 0 and stage 1, and there were increases in stage 2. Reduced stage 1 and increased stage 2 sleep were observed during the recovery night. No effects were observed with stage 3, but there was evidence that stage 4 activity was depressed on the recovery night only. No effects were observed on REM sleep, except that the appearnace of the first REM period was delayed with clorazepate (15 mg) P = 0.01). The effect of nordiazepam (10 mg) and clorazepate (15 mg) were comparable, and each modified sleep for about 28-30 h after ingestion. 4 With nordiazepam (10 mg) and clorazepate (15 mg) the subjects, as a group, reported improved sleep, but subjective assessments of well-being were not altered. Correlations were calculated for sleep measures and subjective assessments.
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- Borland R. G., Nicholson A. N. Comparison of the residual effects of two benzodiazepines (nitrazepam and flurazepam hydrochloride) and pentobarbitone sodium on human performance. Br J Clin Pharmacol. 1975 Feb;2(1):9–17. doi: 10.1111/j.1365-2125.1975.tb00465.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Borland R. G., Nicholson A. N. Human performance after a barbiturate (heptabarbitone). Br J Clin Pharmacol. 1974 Jun;1(3):209–215. doi: 10.1111/j.1365-2125.1974.tb00238.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Borland R. G., Nicholson A. N. Immediate effects on human performance of a 1,5-genzodiazepine (clobazam) compared with the 1,4-benzodiazepines, chlordiazepoxide hydrochloride and diazepam. Br J Clin Pharmacol. 1975 Jun;2(3):215–221. doi: 10.1111/j.1365-2125.1975.tb01578.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Borland R. G., Nicholson A. N., Wright C. M. Behavioural sequelae of methaqualone in man and in the monkey (Macaca mulatta). Br J Clin Pharmacol. 1975 Apr;2(2):131–141. doi: 10.1111/j.1365-2125.1975.tb01568.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Itil T. M., Saletu B., Marasa J. Digital computer analyzed sleep electroencephalogram (sleep prints) in predicting anxiolytic properties of clorazepate dipotassium (tranxene). Curr Ther Res Clin Exp. 1972 Aug;14(8):415–427. [PubMed] [Google Scholar]
- Tansella M., Siciliani O., Burti L., Schiavon M., Zimmermann C., Gerna M., Tognoni G., Morselli P. L. N-desmethyldiazepam and amylobarbitone sodium as hypnotics in anxious patients. Plasma levels, clinical efficacy and residual effects. Psychopharmacologia. 1975;41(2):81–85. doi: 10.1007/BF00421061. [DOI] [PubMed] [Google Scholar]
- Tansella M., Zimmermann-Tansella C., Lader M. The residual effects of N-desmethyldiazepam in patients. Psychopharmacologia. 1974;38(1):81–90. doi: 10.1007/BF00421290. [DOI] [PubMed] [Google Scholar]
- Tognoni G., Gomeni R., De Maio D., Alberti G. G., Franciosi P., Scieghi G. Pharmacokinetics of N-demethyldiazepam in patients suffering from insomnia and treated with nortriptyline. Br J Clin Pharmacol. 1975 Jun;2(3):227–232. doi: 10.1111/j.1365-2125.1975.tb01580.x. [DOI] [PMC free article] [PubMed] [Google Scholar]