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. 1990 Apr;85(4):983–987. doi: 10.1172/JCI114574

Islets of Langerhans: the puzzle of intraislet interactions and their relevance to diabetes.

G C Weir 1, S Bonner-Weir 1
PMCID: PMC296525  PMID: 1969425

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahrén B., Taborsky G. J., Jr, Porte D., Jr Neuropeptidergic versus cholinergic and adrenergic regulation of islet hormone secretion. Diabetologia. 1986 Dec;29(12):827–836. doi: 10.1007/BF00870137. [DOI] [PubMed] [Google Scholar]
  2. Asplin C. M., Paquette T. L., Palmer J. P. In vivo inhibition of glucagon secretion by paracrine beta cell activity in man. J Clin Invest. 1981 Jul;68(1):314–318. doi: 10.1172/JCI110251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bolli G. B., Tsalikian E., Haymond M. W., Cryer P. E., Gerich J. E. Defective glucose counterregulation after subcutaneous insulin in noninsulin-dependent diabetes mellitus. Paradoxical suppression of glucose utilization and lack of compensatory increase in glucose production, roles of insulin resistance, abnormal neuroendocrine responses, and islet paracrine interactions. J Clin Invest. 1984 Jun;73(6):1532–1541. doi: 10.1172/JCI111359. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bonner-Weir S. Morphological evidence for pancreatic polarity of beta-cell within islets of Langerhans. Diabetes. 1988 May;37(5):616–621. doi: 10.2337/diab.37.5.616. [DOI] [PubMed] [Google Scholar]
  5. Bonner-Weir S., Orci L. New perspectives on the microvasculature of the islets of Langerhans in the rat. Diabetes. 1982 Oct;31(10):883–889. doi: 10.2337/diab.31.10.883. [DOI] [PubMed] [Google Scholar]
  6. Fukuda M., Tanaka A., Tahara Y., Ikegami H., Yamamoto Y., Kumahara Y., Shima K. Correlation between minimal secretory capacity of pancreatic beta-cells and stability of diabetic control. Diabetes. 1988 Jan;37(1):81–88. doi: 10.2337/diab.37.1.81. [DOI] [PubMed] [Google Scholar]
  7. Halban P. A., Powers S. L., George K. L., Bonner-Weir S. Spontaneous reassociation of dispersed adult rat pancreatic islet cells into aggregates with three-dimensional architecture typical of native islets. Diabetes. 1987 Jul;36(7):783–790. doi: 10.2337/diab.36.7.783. [DOI] [PubMed] [Google Scholar]
  8. Henderson J. R. Why are the islets of Langerhans? Lancet. 1969 Aug 30;2(7618):469–470. doi: 10.1016/s0140-6736(69)90171-8. [DOI] [PubMed] [Google Scholar]
  9. Hermansen K., Schmitz O., Orskov H. Reversal of D- and A-cell insensitivity to glucose in alloxan-diabetic dogs by treatment with the artificial beta cell (Biostator). Diabetes. 1985 Mar;34(3):260–266. doi: 10.2337/diab.34.3.260. [DOI] [PubMed] [Google Scholar]
  10. Hisatomi A., Maruyama H., Orci L., Vasko M., Unger R. H. Adrenergically mediated intrapancreatic control of the glucagon response to glucopenia in the isolated rat pancreas. J Clin Invest. 1985 Feb;75(2):420–426. doi: 10.1172/JCI111716. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hosker J. P., Burnett M. A., Matthews D. R., Turner R. C. Suppression of insulin secretion by falling plasma glucose levels is impaired in type 2 diabetes. Diabet Med. 1988 Dec;5(9):856–860. doi: 10.1111/j.1464-5491.1988.tb01124.x. [DOI] [PubMed] [Google Scholar]
  12. Klaff L. J., Dunning B. E., Taborsky G. J., Jr Somatostatin-28 does not regulate islet function in the dog. Endocrinology. 1988 Dec;123(6):2668–2674. doi: 10.1210/endo-123-6-2668. [DOI] [PubMed] [Google Scholar]
  13. Lang D. A., Matthews D. R., Peto J., Turner R. C. Cyclic oscillations of basal plasma glucose and insulin concentrations in human beings. N Engl J Med. 1979 Nov 8;301(19):1023–1027. doi: 10.1056/NEJM197911083011903. [DOI] [PubMed] [Google Scholar]
  14. Leahy J. L., Weir G. C. Unresponsiveness to glucose in a streptozocin model of diabetes. Inappropriate insulin and glucagon responses to a reduction of glucose concentration. Diabetes. 1985 Jul;34(7):653–659. doi: 10.2337/diab.34.7.653. [DOI] [PubMed] [Google Scholar]
  15. Leiter E. H., Gapp D. A., Eppig J. J., Coleman D. L. Ultrastructural and morphometric studies of delta cells in pancreatic islets from C57BL/Ks diabetes mice. Diabetologia. 1979 Nov;17(5):297–309. doi: 10.1007/BF01235886. [DOI] [PubMed] [Google Scholar]
  16. Lifson N., Kramlinger K. G., Mayrand R. R., Lender E. J. Blood flow to the rabbit pancreas with special reference to the islets of Langerhans. Gastroenterology. 1980 Sep;79(3):466–473. [PubMed] [Google Scholar]
  17. Louie D. S., Williams J. A., Owyang C. Action of pancreatic polypeptide on rat pancreatic secretion: in vivo and in vitro. Am J Physiol. 1985 Oct;249(4 Pt 1):G489–G495. doi: 10.1152/ajpgi.1985.249.4.G489. [DOI] [PubMed] [Google Scholar]
  18. Meglasson M. D., Matschinsky F. M. Pancreatic islet glucose metabolism and regulation of insulin secretion. Diabetes Metab Rev. 1986;2(3-4):163–214. doi: 10.1002/dmr.5610020301. [DOI] [PubMed] [Google Scholar]
  19. O'Rahilly S., Turner R. C., Matthews D. R. Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes. N Engl J Med. 1988 May 12;318(19):1225–1230. doi: 10.1056/NEJM198805123181902. [DOI] [PubMed] [Google Scholar]
  20. Orci L., Thorens B., Ravazzola M., Lodish H. F. Localization of the pancreatic beta cell glucose transporter to specific plasma membrane domains. Science. 1989 Jul 21;245(4915):295–297. doi: 10.1126/science.2665080. [DOI] [PubMed] [Google Scholar]
  21. Pipeleers D. The biosociology of pancreatic B cells. Diabetologia. 1987 May;30(5):277–291. doi: 10.1007/BF00299019. [DOI] [PubMed] [Google Scholar]
  22. Rappaport E. B., Young J. B., Landsberg L. Effects of 2-deoxy-D-glucose on the cardiac sympathetic nerves and the adrenal medulla in the rat: further evidence for a dissociation of sympathetic nervous system and adrenal medullary responses. Endocrinology. 1982 Feb;110(2):650–656. doi: 10.1210/endo-110-2-650. [DOI] [PubMed] [Google Scholar]
  23. Raskin P., Aydin I., Unger R. H. Effect of insulin on the exaggerated glucagon response to arginine stimulation in diabetes mellitus. Diabetes. 1976 Mar;25(3):227–229. doi: 10.2337/diab.25.3.227. [DOI] [PubMed] [Google Scholar]
  24. Salomon D., Meda P. Heterogeneity and contact-dependent regulation of hormone secretion by individual B cells. Exp Cell Res. 1986 Feb;162(2):507–520. doi: 10.1016/0014-4827(86)90354-x. [DOI] [PubMed] [Google Scholar]
  25. Samols E., Bonner-Weir S., Weir G. C. Intra-islet insulin-glucagon-somatostatin relationships. Clin Endocrinol Metab. 1986 Feb;15(1):33–58. doi: 10.1016/s0300-595x(86)80041-x. [DOI] [PubMed] [Google Scholar]
  26. Samols E., Stagner J. I. Intra-islet regulation. Am J Med. 1988 Nov 28;85(5A):31–35. doi: 10.1016/0002-9343(88)90395-6. [DOI] [PubMed] [Google Scholar]
  27. Schauder P., McIntosh C., Arends J., Arnold R., Frerichs H., Creutzfeldt W. Somatostatin and insulin release from isolated rat pancreatic islets stimulated by glucose. FEBS Lett. 1976 Oct 1;68(2):225–227. doi: 10.1016/0014-5793(76)80441-3. [DOI] [PubMed] [Google Scholar]
  28. Schuit F. C., In't Veld P. A., Pipeleers D. G. Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells. Proc Natl Acad Sci U S A. 1988 Jun;85(11):3865–3869. doi: 10.1073/pnas.85.11.3865. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Scott A. M., Atwater I., Rojas E. A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of Langerhans. Diabetologia. 1981 Nov;21(5):470–475. doi: 10.1007/BF00257788. [DOI] [PubMed] [Google Scholar]
  30. Stagner J. I., Samols E., Weir G. C. Sustained oscillations of insulin, glucagon, and somatostatin from the isolated canine pancreas during exposure to a constant glucose concentration. J Clin Invest. 1980 Apr;65(4):939–942. doi: 10.1172/JCI109750. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Stefan Y., Meda P., Neufeld M., Orci L. Stimulation of insulin secretion reveals heterogeneity of pancreatic B cells in vivo. J Clin Invest. 1987 Jul;80(1):175–183. doi: 10.1172/JCI113045. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Unger R. H. Glucagon physiology and pathophysiology in the light of new advances. Diabetologia. 1985 Aug;28(8):574–578. doi: 10.1007/BF00281991. [DOI] [PubMed] [Google Scholar]
  33. Weir G. C., Knowlton S. D., Atkins R. F., McKennan K. X., Martin D. B. Glucagon secretion from the perfused pancreas of streptozotocin-treated rats. Diabetes. 1976 Apr;25(4):275–282. doi: 10.2337/diab.25.4.275. [DOI] [PubMed] [Google Scholar]
  34. Weir G. C., Leahy J. L., Bonner-Weir S. Experimental reduction of B-cell mass: implications for the pathogenesis of diabetes. Diabetes Metab Rev. 1986;2(1-2):125–161. doi: 10.1002/dmr.5610020108. [DOI] [PubMed] [Google Scholar]

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