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. 1990 Nov;86(5):1381–1386. doi: 10.1172/JCI114851

Antibiotic proteins of human neutrophils.

J K Spitznagel 1
PMCID: PMC296879  PMID: 2243118

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Selected References

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  1. Bangalore N., Travis J., Onunka V. C., Pohl J., Shafer W. M. Identification of the primary antimicrobial domains in human neutrophil cathepsin G. J Biol Chem. 1990 Aug 15;265(23):13584–13588. [PubMed] [Google Scholar]
  2. Campanelli D., Detmers P. A., Nathan C. F., Gabay J. E. Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties. J Clin Invest. 1990 Mar;85(3):904–915. doi: 10.1172/JCI114518. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Daher K. A., Lehrer R. I., Ganz T., Kronenberg M. Isolation and characterization of human defensin cDNA clones. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7327–7331. doi: 10.1073/pnas.85.19.7327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Farley M. M., Shafer W. M., Spitznagel J. K. Lipopolysaccharide structure determines ionic and hydrophobic binding of a cationic antimicrobial neutrophil granule protein. Infect Immun. 1988 Jun;56(6):1589–1592. doi: 10.1128/iai.56.6.1589-1592.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gabay J. E., Scott R. W., Campanelli D., Griffith J., Wilde C., Marra M. N., Seeger M., Nathan C. F. Antibiotic proteins of human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5610–5614. doi: 10.1073/pnas.86.14.5610. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ganz T. Extracellular release of antimicrobial defensins by human polymorphonuclear leukocytes. Infect Immun. 1987 Mar;55(3):568–571. doi: 10.1128/iai.55.3.568-571.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ganz T., Metcalf J. A., Gallin J. I., Boxer L. A., Lehrer R. I. Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency. J Clin Invest. 1988 Aug;82(2):552–556. doi: 10.1172/JCI113631. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gray P. W., Flaggs G., Leong S. R., Gumina R. J., Weiss J., Ooi C. E., Elsbach P. Cloning of the cDNA of a human neutrophil bactericidal protein. Structural and functional correlations. J Biol Chem. 1989 Jun 5;264(16):9505–9509. [PubMed] [Google Scholar]
  9. Greenwald G. I., Ganz T. Defensins mediate the microbicidal activity of human neutrophil granule extract against Acinetobacter calcoaceticus. Infect Immun. 1987 Jun;55(6):1365–1368. doi: 10.1128/iai.55.6.1365-1368.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Holmes B., Page A. R., Good R. A. Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function. J Clin Invest. 1967 Sep;46(9):1422–1432. doi: 10.1172/JCI105634. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hovde C. J., Gray B. H. Characterization of a protein from normal human polymorphonuclear leukocytes with bactericidal activity against Pseudomonas aeruginosa. Infect Immun. 1986 Oct;54(1):142–148. doi: 10.1128/iai.54.1.142-148.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hovde C. J., Gray B. H. Physiological effects of a bactericidal protein from human polymorphonuclear leukocytes on Pseudomonas aeruginosa. Infect Immun. 1986 Apr;52(1):90–95. doi: 10.1128/iai.52.1.90-95.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kagan B. L., Selsted M. E., Ganz T., Lehrer R. I. Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proc Natl Acad Sci U S A. 1990 Jan;87(1):210–214. doi: 10.1073/pnas.87.1.210. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Lehrer R. I., Barton A., Daher K. A., Harwig S. S., Ganz T., Selsted M. E. Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. J Clin Invest. 1989 Aug;84(2):553–561. doi: 10.1172/JCI114198. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Mannion B. A., Kalatzis E. S., Weiss J., Elsbach P. Preferential binding of the neutrophil cytoplasmic granule-derived bactericidal/permeability increasing protein to target bacteria. Implications and use as a means of purification. J Immunol. 1989 Apr 15;142(8):2807–2812. [PubMed] [Google Scholar]
  16. Marra M. N., Wilde C. G., Griffith J. E., Snable J. L., Scott R. W. Bactericidal/permeability-increasing protein has endotoxin-neutralizing activity. J Immunol. 1990 Jan 15;144(2):662–666. [PubMed] [Google Scholar]
  17. Ooi C. E., Weiss J., Elsbach P., Frangione B., Mannion B. A 25-kDa NH2-terminal fragment carries all the antibacterial activities of the human neutrophil 60-kDa bactericidal/permeability-increasing protein. J Biol Chem. 1987 Nov 5;262(31):14891–14894. [PubMed] [Google Scholar]
  18. Pereira H. A., Shafer W. M., Pohl J., Martin L. E., Spitznagel J. K. CAP37, a human neutrophil-derived chemotactic factor with monocyte specific activity. J Clin Invest. 1990 May;85(5):1468–1476. doi: 10.1172/JCI114593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Pereira H. A., Spitznagel J. K., Pohl J., Wilson D. E., Morgan J., Palings I., Larrick J. W. CAP 37, a 37 kD human neutrophil granule cationic protein shares homology with inflammatory proteinases. Life Sci. 1990;46(3):189–196. doi: 10.1016/0024-3205(90)90104-y. [DOI] [PubMed] [Google Scholar]
  20. Rotrosen D., Gallin J. I. Disorders of phagocyte function. Annu Rev Immunol. 1987;5:127–150. doi: 10.1146/annurev.iy.05.040187.001015. [DOI] [PubMed] [Google Scholar]
  21. Salvesen G., Farley D., Shuman J., Przybyla A., Reilly C., Travis J. Molecular cloning of human cathepsin G: structural similarity to mast cell and cytotoxic T lymphocyte proteinases. Biochemistry. 1987 Apr 21;26(8):2289–2293. doi: 10.1021/bi00382a032. [DOI] [PubMed] [Google Scholar]
  22. Selsted M. E., Harwig S. S. Determination of the disulfide array in the human defensin HNP-2. A covalently cyclized peptide. J Biol Chem. 1989 Mar 5;264(7):4003–4007. [PubMed] [Google Scholar]
  23. Shafer W. M., Engle S. A., Martin L. E., Spitznagel J. K. Killing of Proteus mirabilis by polymorphonuclear leukocyte granule proteins: evidence for species specificity by antimicrobial proteins. Infect Immun. 1988 Jan;56(1):51–53. doi: 10.1128/iai.56.1.51-53.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Shafer W. M., Martin L. E., Spitznagel J. K. Cationic antimicrobial proteins isolated from human neutrophil granulocytes in the presence of diisopropyl fluorophosphate. Infect Immun. 1984 Jul;45(1):29–35. doi: 10.1128/iai.45.1.29-35.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Shafer W. M., Martin L. E., Spitznagel J. K. Late intraphagosomal hydrogen ion concentration favors the in vitro antimicrobial capacity of a 37-kilodalton cationic granule protein of human neutrophil granulocytes. Infect Immun. 1986 Sep;53(3):651–655. doi: 10.1128/iai.53.3.651-655.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Shafer W. M., Onunka V. C., Martin L. E. Antigonococcal activity of human neutrophil cathepsin G. Infect Immun. 1986 Oct;54(1):184–188. doi: 10.1128/iai.54.1.184-188.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Shafer W. M., Onunka V. C. Mechanism of staphylococcal resistance to non-oxidative antimicrobial action of neutrophils: importance of pH and ionic strength in determining the bactericidal action of cathepsin G. J Gen Microbiol. 1989 Apr;135(4):825–830. doi: 10.1099/00221287-135-4-825. [DOI] [PubMed] [Google Scholar]
  28. Sparkes R. S., Kronenberg M., Heinzmann C., Daher K. A., Klisak I., Ganz T., Mohandas T. Assignment of defensin gene(s) to human chromosome 8p23. Genomics. 1989 Aug;5(2):240–244. doi: 10.1016/0888-7543(89)90052-9. [DOI] [PubMed] [Google Scholar]
  29. Spitznagel J. K. Nonoxidative antimicrobial reactions of leukocytes. Contemp Top Immunobiol. 1984;14:283–343. doi: 10.1007/978-1-4757-4862-8_10. [DOI] [PubMed] [Google Scholar]
  30. Spitznagel J. K., Pereira H. A., Martin L. E., Guzman G. S., Shafer W. M. A monoclonal antibody that inhibits the antimicrobial action of a 57 KD cationic protein of human polymorphonuclear leukocytes. J Immunol. 1987 Aug 15;139(4):1291–1296. [PubMed] [Google Scholar]
  31. Stanfield R. L., Westbrook E. M., Selsted M. E. Characterization of two crystal forms of human defensin neutrophil cationic peptide 1, a naturally occurring antimicrobial peptide of leukocytes. J Biol Chem. 1988 Apr 25;263(12):5933–5935. [PubMed] [Google Scholar]
  32. Stinavage P., Martin L. E., Spitznagel J. K. O antigen and lipid A phosphoryl groups in resistance of Salmonella typhimurium LT-2 to nonoxidative killing in human polymorphonuclear neutrophils. Infect Immun. 1989 Dec;57(12):3894–3900. doi: 10.1128/iai.57.12.3894-3900.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Territo M. C., Ganz T., Selsted M. E., Lehrer R. Monocyte-chemotactic activity of defensins from human neutrophils. J Clin Invest. 1989 Dec;84(6):2017–2020. doi: 10.1172/JCI114394. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Tobias P. S., Mathison J. C., Ulevitch R. J. A family of lipopolysaccharide binding proteins involved in responses to gram-negative sepsis. J Biol Chem. 1988 Sep 25;263(27):13479–13481. [PubMed] [Google Scholar]
  35. Viljanen P., Koski P., Vaara M. Effect of small cationic leukocyte peptides (defensins) on the permeability barrier of the outer membrane. Infect Immun. 1988 Sep;56(9):2324–2329. doi: 10.1128/iai.56.9.2324-2329.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Weiss J., Kao L., Victor M., Elsbach P. Oxygen-independent intracellular and oxygen-dependent extracellular killing of Escherichia coli S15 by human polymorphonuclear leukocytes. J Clin Invest. 1985 Jul;76(1):206–212. doi: 10.1172/JCI111947. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Weiss J., Muello K., Victor M., Elsbach P. The role of lipopolysaccharides in the action of the bactericidal/permeability-increasing neutrophil protein on the bacterial envelope. J Immunol. 1984 Jun;132(6):3109–3115. [PubMed] [Google Scholar]
  38. Weiss J., Olsson I. Cellular and subcellular localization of the bactericidal/permeability-increasing protein of neutrophils. Blood. 1987 Feb;69(2):652–659. [PubMed] [Google Scholar]
  39. Wilde C. G., Griffith J. E., Marra M. N., Snable J. L., Scott R. W. Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family. J Biol Chem. 1989 Jul 5;264(19):11200–11203. [PubMed] [Google Scholar]

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