Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1967 Jun;46(6):903–910. doi: 10.1172/JCI105596

Diffusion of Glucose, Insulin, Inulin, and Evans Blue Protein into Thoracic Duct Lymph of Man*

Eugenio A Rasio 1,†, Constantine L Hampers 1, J Stuart Soeldner 1, George F Cahill Jr 1,‡
PMCID: PMC297094  PMID: 6026096

Abstract

Immunoreactive insulin, like inulin, quickly equilibrates with interstitial fluid, as evidenced by recovery in thoracic duct lymph in man. Insulin-like activity not accounted for by immunoreactive insulin behaves as a large protein and is confined to the vascular compartment.

Full text

PDF
903

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANTONIADES H. N., BOUGAS J. A., CAMERINI-DAVALOS R., PYLE H. M. INSULIN REGULATORY MECHANISMS AND DIABETES MELLITUS. Diabetes. 1964 May-Jun;13:230–240. [PubMed] [Google Scholar]
  2. ANTONIADES H. N., HUBER A. M., BOSHELL B. R., SARAVIS C. A., GERSHOFF S. N. STUDIES ON THE STATE OF INSULIN IN BLOOD: PROPERTIES OF CIRCULATING "FREE" AND "BOUND" INSULIN. Endocrinology. 1965 Apr;76:709–721. doi: 10.1210/endo-76-4-709. [DOI] [PubMed] [Google Scholar]
  3. Berson S. A., Yalow R. S. Insulin in blood and insulin antibodies. Am J Med. 1966 May;40(5):676–690. doi: 10.1016/0002-9343(66)90148-3. [DOI] [PubMed] [Google Scholar]
  4. Bürgi H., Müller W. A., Humbel R. E., Labhart A., Froesch E. R. Non-suppressible insulin-like activity of human serum. I. Physicochemical properties, extraction and partial purification. Biochim Biophys Acta. 1966 Jun 29;121(2):349–359. doi: 10.1016/0304-4165(66)90124-3. [DOI] [PubMed] [Google Scholar]
  5. CERASI E., LUFT R. INSULIN RESPONSE TO GLUCOSE LOADING IN ACROMEGALY. Lancet. 1964 Oct 10;2(7363):769–771. doi: 10.1016/s0140-6736(64)90556-2. [DOI] [PubMed] [Google Scholar]
  6. CONSTABLE B. J. Estimation of Evans blue dye in blood plasma and its application to blood volume determination. Clin Sci. 1958 Nov;17(4):597–602. [PubMed] [Google Scholar]
  7. DANIEL P. M., GALE M. M., PRATT O. E. THE CONCENTRATION OF RADIOACTIVE IODINE IN THE THYROID LYMPH, THYROID VENOUS BLOOD AND PERIPHERAL BLOOD OF PRIMATES. J Physiol. 1963 Nov;169:330–338. doi: 10.1113/jphysiol.1963.sp007259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. FREDRICKSON D. S., GORDON R. S., Jr Transport of fatty acids. Physiol Rev. 1958 Oct;38(4):585–630. doi: 10.1152/physrev.1958.38.4.585. [DOI] [PubMed] [Google Scholar]
  9. FROESCH E. R., REARDON J. B., RENOLD A. E. The determination of inulin in blood and urine using glucose oxidase for the removal of interfering glucose. J Lab Clin Med. 1957 Dec;50(6):918–921. [PubMed] [Google Scholar]
  10. MAHON W. A., STEINKE J., McKHANN G. M., MITCHELL M. L. Measurement of I-131-insulin and of insulin-like activity in cerebrospinal fluid of man. Metabolism. 1962 Apr;11:416–420. [PubMed] [Google Scholar]
  11. RENOLD A. E., MARTIN D. B., DAGENAIS Y. M., STEINKE J., NICKERSON R. J., SHEPS M. C. Measurement of small quantities of insulin-like activity using rat adipose tissue. I. A proposed procedure. J Clin Invest. 1960 Sep;39:1487–1498. doi: 10.1172/JCI104168. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. SAMAAN N., FRASER R., DEMPSTER W. J. THE "TYPICAL" AND "ATYPICAL" FORMS OF SERUM INSULIN. Diabetes. 1963 Jul-Aug;12:339–348. doi: 10.2337/diab.12.4.339. [DOI] [PubMed] [Google Scholar]
  13. SKINNER S. L., MCCUBBIN J. W., PAGE I. H. ANGIOTENSIN IN BLOOD AND LYMPH FOLLOWING REDUCTION IN RENAL ARTERIAL PERFUSION PRESSURE IN DOGS. Circ Res. 1963 Oct;13:336–345. doi: 10.1161/01.res.13.4.336. [DOI] [PubMed] [Google Scholar]
  14. Soeldner J. S., Slone D. Critical variables in the radioimmunoassay of serum insulin using the double antibody technic. Diabetes. 1965 Dec;14(12):771–779. doi: 10.2337/diab.14.12.771. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES