Abstract
If water and inert solutes are assumed to pass from blood to bile through a fixed population of membrane pores, the changes in clearance produced by dehydrocholate suggest that osmotic filtration rather than diffusion is the predominant mode of transfer for mannitol and erythritol. Bile produced in the canaliculi is modified in the interlobular ducts by the action of secretin. If distal fluid transfer is an important determinant of the choleresis evoked by dehydrocholate, the mechanism appears to effect a net secretion or reabsorption of fluid at a rate roughly proportional to the rate of flow in the canaliculi.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- COOK D. L., LAWLER C. A., CALVIN L. D., GREEN D. M. Mechanisms of bile formation. Am J Physiol. 1952 Oct;171(1):62–74. doi: 10.1152/ajplegacy.1952.171.1.62. [DOI] [PubMed] [Google Scholar]
- Chenderovitch J., Phocas E., Rautureau M. Effects of hypertonic solutions on bile formation. Am J Physiol. 1963 Nov;205(5):863–867. doi: 10.1152/ajplegacy.1963.205.5.863. [DOI] [PubMed] [Google Scholar]
- DURBIN R. P. Osmotic flow of water across permeable cellulose membranes. J Gen Physiol. 1960 Nov;44:315–326. doi: 10.1085/jgp.44.2.315. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Forker E. L., Hogben C. A. Diodrast transit time in guinea pig biliary tree. Am J Physiol. 1967 Jan;212(1):104–112. doi: 10.1152/ajplegacy.1967.212.1.104. [DOI] [PubMed] [Google Scholar]
- McCORKINDALE J., EDSON N. L. Polyol dehydrogenases. I. The specificity of rat-liver polyol dehydrogenase. Biochem J. 1954 Jul;57(3):518–523. doi: 10.1042/bj0570518. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RENKIN E. M. Filtration, diffusion, and molecular sieving through porous cellulose membranes. J Gen Physiol. 1954 Nov 20;38(2):225–243. [PMC free article] [PubMed] [Google Scholar]
- SCHANKER L. S., HOGBEN C. A. Biliary excretion of inulin, sucrose, and mannitol: analysis of bile formation. Am J Physiol. 1961 May;200:1087–1090. doi: 10.1152/ajplegacy.1961.200.5.1087. [DOI] [PubMed] [Google Scholar]
- SPERBER I. Secretion of organic anions in the formation of urine and bile. Pharmacol Rev. 1959 Mar;11(1):109–134. [PubMed] [Google Scholar]
- Wheeler H. O., Mancusi-Ungaro P. L. Role of bile ducts during secretin choleresis in dogs. Am J Physiol. 1966 May;210(5):1153–1159. doi: 10.1152/ajplegacy.1966.210.5.1153. [DOI] [PubMed] [Google Scholar]