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. 1968 Jan;47(1):26–37. doi: 10.1172/JCI105712

Estimation of thyroxine distribution in man

J T Nicoloff 1,2,3, J Thomas Dowling 1,2,3
PMCID: PMC297145  PMID: 16695944

Abstract

A group of 13 normal subjects were evaluated for their extrathyroidal thyroxine distribution. The method employed the measurement of the acute plasma disappearance of a thyroxine-131I tracer and its concomitant uptake into the liver and forearm. The analysis of these parameters allowed the theoretical construction of a four compartmental mathematical model system comprised of the plasma, extracellular fluid, hepatic, and extrahepatic thyroxine pools. The results of this analysis revealed that the exchange of thyroxine from the plasma into the hepatic and extrahepatic cellular fluid spaces appeared, in general, to be rapid, while the uptake into the extrahepatic tissues was relatively slow. The calculated distribution of thyroxine at equilibrium was estimated to be 14% in liver, 34% in extrahepatic tissues, and 26% each in the plasma and extracellular fluid pools in this group of normal subjects.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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