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. 1968 May;47(5):983–991. doi: 10.1172/JCI105813

The phosphaturic effect of sodium bicarbonate and acetazolamide in dogs

Milford Fulop 1,2, Paul Brazeau 1,2
PMCID: PMC297251  PMID: 5645865

Abstract

Urinary inorganic phosphate excretion was studied before and during the administration of sodium bicarbonate and acetazolamide in dogs that were not given infusions of phosphate. The excretion fraction of filtered phosphate increased after sodium bicarbonate or acetazolamide was given. This phosphaturia was attributed to decreased tubular reabsorption of phosphate consequent to alkalinization of either tubular urine or cells.

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Selected References

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  1. Aurbach G. D., Potts J. T., Jr Parathyroid hormone. Am J Med. 1967 Jan;42(1):1–8. doi: 10.1016/0002-9343(67)90002-2. [DOI] [PubMed] [Google Scholar]
  2. BERLINER R. W., KENNEDY T. J., Jr, ORLOFF J. Relationship between acidification of the urine and potassium metabolism; effect of carbonic anhydrase inhibition on potassium excretion. Am J Med. 1951 Sep;11(3):274–282. doi: 10.1016/0002-9343(51)90165-9. [DOI] [PubMed] [Google Scholar]
  3. BERLINER R. W., ORLOFF J. Carbonic anhydrase inhibitors. Pharmacol Rev. 1956 Jun;8(2):137–174. [PubMed] [Google Scholar]
  4. CARRASQUER G., BRODSKY W. A. Eliminatio of transient secretion of phosphate by alkalinization of plasma in dogs. Am J Physiol. 1961 Sep;201:499–504. doi: 10.1152/ajplegacy.1961.201.3.499. [DOI] [PubMed] [Google Scholar]
  5. Edwards N. A., Hodgkinson A. Phosphate metabolism in patients with renal calculus. Clin Sci. 1965 Aug;29(1):93–106. [PubMed] [Google Scholar]
  6. HANDLER J. S. A study of renal phosphate excretion in the dog. Am J Physiol. 1962 Apr;202:787–790. doi: 10.1152/ajplegacy.1962.202.4.787. [DOI] [PubMed] [Google Scholar]
  7. HODGKINSON A., PYRAH L. N. The urinary excretion of calcium and inorganic phosphate in 344 patients with calcium stone of renal origin. Br J Surg. 1958 Jul;46(195):10–18. doi: 10.1002/bjs.18004619504. [DOI] [PubMed] [Google Scholar]
  8. Harrison H. E., Harrison H. C. THE RENAL EXCRETION OF INORGANIC PHOSPHATE IN RELATION TO THE ACTION OF VITAMIN D AND PARATHYROID HORMONE. J Clin Invest. 1941 Jan;20(1):47–55. doi: 10.1172/JCI101194. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hebert L. A., Lemann J., Jr, Petersen J. R., Lennon E. J. Studies of the mechanism by which phosphate infusion lowers serum calcium concentration. J Clin Invest. 1966 Dec;45(12):1886–1894. doi: 10.1172/JCI105493. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. LEVINSKY N. G., DAVIDSON D. G. Renal action of parathyroid extract in the chicken. Am J Physiol. 1957 Dec;191(3):530–536. doi: 10.1152/ajplegacy.1957.191.3.530. [DOI] [PubMed] [Google Scholar]
  11. LOTSPEICH W. D., MALVIN R. L. Relation between tubular transport of inorganic phosphate and bicarbonate in the dog. Am J Physiol. 1956 Sep;187(1):51–56. doi: 10.1152/ajplegacy.1956.187.1.51. [DOI] [PubMed] [Google Scholar]
  12. MARTIN H. E., JONES R. The effect of ammonium chloride and sodium bicarbonate on the urinary excretion of magnesium, calcium, and phosphate. Am Heart J. 1961 Aug;62:206–210. doi: 10.1016/0002-8703(61)90319-2. [DOI] [PubMed] [Google Scholar]
  13. MOSTELLAR M. E., TUTTLE E. P., Jr EFFECTS OF ALKALOSIS ON PLASMA CONCENTRATION AND URINARY EXCRETION OF INORGANIC PHOSPHATE IN MAN. J Clin Invest. 1964 Jan;43:138–149. doi: 10.1172/JCI104888. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. NADELL J. The effects of the carbonic anhydrase inhibitor 6063 on electrolytes and acid-base balance in two normal subjects and two patients with respiratory acidosis. J Clin Invest. 1953 Jul;32(7):622–629. doi: 10.1172/JCI102773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. NICHOLSON T. F., SHEPHERD G. W. The effect of damage to various parts of the renal tubule on the excretion of phosphate by the dog's kidney. Can J Biochem Physiol. 1959 Jan;37(1):103–111. [PubMed] [Google Scholar]
  16. PULLMAN T. N., LAVENDER A. R., AHO I., RASMUSSEN H. Direct renal action of a purified parathyroid extract. Endocrinology. 1960 Nov;67:570–582. doi: 10.1210/endo-67-5-570. [DOI] [PubMed] [Google Scholar]
  17. RECTOR F. C., Jr, CARTER N. W., SELDIN D. W. THE MECHANISM OF BICARBONATE REABSORPTION IN THE PROXIMAL AND DISTAL TUBULES OF THE KIDNEY. J Clin Invest. 1965 Feb;44:278–290. doi: 10.1172/JCI105142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. SELDIN D. W., TARAIL R. Effect of hypertonic solutions on metabolism and excretion of electrolytes. Am J Physiol. 1949 Oct;159(1):160–174. doi: 10.1152/ajplegacy.1949.159.1.160. [DOI] [PubMed] [Google Scholar]
  19. STRICKLER J. C., THOMPSON D. D., KLOSE R. M., GIEBISCH G. MICROPUNCTURE STUDY OF INORGANIC PHOSPHATE EXCRETION IN THE RAT. J Clin Invest. 1964 Aug;43:1596–1607. doi: 10.1172/JCI105035. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Sartorius O. W., Roemmelt J. C., Pitts R. F., Calhoon D., Miner P. THE RENAL REGULATION OF ACID-BASE BALANCE IN MAN. IV. THE NATURE OF THE RENAL COMPENSATIONS IN AMMONIUM CHLORIDE ACIDOSIS. J Clin Invest. 1949 May;28(3):423–439. doi: 10.1172/JCI102087. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. TAUSSKY H. H., SHORR E. A microcolorimetric method for the determination of inorganic phosphorus. J Biol Chem. 1953 Jun;202(2):675–685. [PubMed] [Google Scholar]
  22. WALSER M. Protein-binding of inorganic phosphate in plasma of normal subjects and patients with renal disease. J Clin Invest. 1960 Mar;39:501–506. doi: 10.1172/JCI104064. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. WESSON L. G., Jr Magnesium, calcium, and phosphate excretion during osmotic diuresis in the dog. J Lab Clin Med. 1962 Sep;60:422–432. [PubMed] [Google Scholar]

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