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. 1989 Sep;86(18):7038–7042. doi: 10.1073/pnas.86.18.7038

Microinjection of antisense c-mos oligonucleotides prevents meiosis II in the maturing mouse egg.

S J O'Keefe 1, H Wolfes 1, A A Kiessling 1, G M Cooper 1
PMCID: PMC297988  PMID: 2476810

Abstract

Injection of antisense oligonucleotides was used to investigate the function of c-mos in murine oocytes. Oocytes injected with antisense c-mos oligonucleotides completed the first meiotic division but failed to initiate meiosis II. Instead, loss of c-mos function led to chromosome decondensation, reformation of a nucleus after meiosis I, and cleavage to two cells. Therefore, c-mos is required for meiosis II during murine oocyte maturation.

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Selected References

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