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. 1989 Sep;86(18):7067–7071. doi: 10.1073/pnas.86.18.7067

Duplication of large genomic regions during the evolution of vertebrate homeobox genes.

K Schughart 1, C Kappen 1, F H Ruddle 1
PMCID: PMC297995  PMID: 2571149

Abstract

The phylogenetic relationships of 21 murine Antp-class (Drosophila mutation Antennapedia-type class) homeobox genes have been analyzed, and several groups of related genes have been identified. The murine Antp-class homeobox genes are localized within four gene clusters. The similar structural organization of the four gene clusters strongly suggests that genes within a group of related Antp-class homeobox genes are derived from duplications of large genomic regions. After the duplication, the gross structures of the homeobox gene clusters have been maintained over a long period of evolutionary time, indicating that the specific organization of genes within a cluster may be of functional importance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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