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. 1987 Sep;84(17):6215–6219. doi: 10.1073/pnas.84.17.6215

Recombinational substrates designed to study recombination between unique and repetitive sequences in vivo.

M T Fasullo, R W Davis
PMCID: PMC299041  PMID: 3306671

Abstract

Three recombination events, reciprocal recombination, sister-chromatid recombination, and gene conversion, were studied using substrates designed in vitro. Each type of recombination event can be monitored at any chromosomal location. We have shown that sister-chromatid recombination is induced mitotically by DNA damaging agents, such as methyl methanesulfonate and gamma-rays, but is decreased mitotically in strains defective in rad52. Reciprocal recombination by which circular plasmids integrate into the genome is unaffected by rad52 defective alleles and occurs by a different recombination pathway. Mechanisms are suggested by which gene conversion between sister chromatids can generate chromosome rearrangements.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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