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. 1973 Apr;52(4):961–964. doi: 10.1172/JCI107261

Evidence for Stimulation of Renal Gluconeogenesis by Catecholamines

Kiyoshi Kurokawa 1,2, Shaul G Massry 1,2
PMCID: PMC302344  PMID: 4348346

Abstract

Isoproterenol and norepinephrine (10-4 M) significantly increased cyclic AMP formation and glucose production by the isolated tubules of the renal cortex of the rat. These effects were abolished by propranolol. Theophylline diminished the effects of the catecholamines on gluconeogenesis despite a marked augmentation in cyclic AMP concentration. In the absence of calcium ion in the incubation medium, isoproterenol stimulates cyclic AMP production, but has no effect on gluconeogenesis. It is concluded that catecholamines enhance gluconeogenesis in renal cortical tubules by the stimulation of beta adrenergic receptors. This effect is probably mediated through adenyl cyclase-cyclic AMP system and requires an adequate level of ATP and the presence of calcium ion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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