Skip to main content
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1973 Jun;52(6):1410–1414. doi: 10.1172/JCI107314

In Vitro Myelosuppression and Immunosuppression by Ethanol

Glenn Tisman 1,2, Victor Herbert 1,2
PMCID: PMC302405  PMID: 4703227

Abstract

Concentrations of ethanol similar to those in the blood of intoxicated patients suppressed phytohemagglutinin- or streptolysin O-induced lymphocyte transformation, and inhibited bone marrow granulocyte colony growth in soft agar. Inhibition of lymphocyte transformation and granulocyte colony growth occurred despite the presence of large concentrations of folate and other vitamins. These in vitro findings may relate to in vivo effects of ethanol on myeloid and lymphoid tissue.

Full text

PDF
1411

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chervenick P. A., LoBuglio A. F. Human blood monocytes: stimulators of granulocyte and mononuclear colony formation in vitro. Science. 1972 Oct 13;178(4057):164–166. doi: 10.1126/science.178.4057.164. [DOI] [PubMed] [Google Scholar]
  2. Corcino J., Krauss S., Waxman S., Herbert V. Release of vitamin B12--binding protein by human leukocytes in vitro. J Clin Invest. 1970 Dec;49(12):2250–2255. doi: 10.1172/JCI106444. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DAUGHADAY W. H., PARKER M. L. Sulfation factor measurement as an aid in the recognition of pituitary dwarfism. J Clin Endocrinol Metab. 1963 Jul;23:638–650. doi: 10.1210/jcem-23-7-638. [DOI] [PubMed] [Google Scholar]
  4. Golde D. W., Cline M. J. Identification of the colony-stimulating cell in human peripheral blood. J Clin Invest. 1972 Nov;51(11):2981–2983. doi: 10.1172/JCI107124. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Golde D. W., Finley T. N., Cline M. J. Production of colony-stimulating factor by human macrophages. Lancet. 1972 Dec 30;2(7792):1397–1399. doi: 10.1016/s0140-6736(72)92966-2. [DOI] [PubMed] [Google Scholar]
  6. Guarneri J. J., Laurenzi G. A. Effect of alcohol on the mobilization of alveolar macrophages. J Lab Clin Med. 1968 Jul;72(1):40–51. [PubMed] [Google Scholar]
  7. Kurnick J. E., Robison W. A. Clony growth of human peripherl white blood cells in vitro. Blood. 1971 Feb;37(2):136–141. [PubMed] [Google Scholar]
  8. Lindenbaum J., Hargrove R. L. Thrombocytopenia in alcoholics. Ann Intern Med. 1968 Mar;68(3):526–532. doi: 10.7326/0003-4819-68-3-526. [DOI] [PubMed] [Google Scholar]
  9. MCFARLAND W., LIBRE E. P. ABNORMAL LEUKOCYTE RESPONSE IN ALCOHOLISM. Ann Intern Med. 1963 Dec;59:865–877. doi: 10.7326/0003-4819-59-6-865. [DOI] [PubMed] [Google Scholar]
  10. Metz J., Kelly A., Swett V. C., Waxman S., Herbert V. Deranged DNA synthesis by bone marrow from vitamin B-12-deficient humans. Br J Haematol. 1968 Jun;14(6):575–592. doi: 10.1111/j.1365-2141.1968.tb00364.x. [DOI] [PubMed] [Google Scholar]
  11. Ogawa M., Bergsagel D. E., McCulloch E. A. Chemotherapy of mouse myeloma: quantitative cell cultures predictive of response in vivo. Blood. 1973 Jan;41(1):7–15. [PubMed] [Google Scholar]
  12. Ogawa M., Bergsagel D. E., McCulloch E. A. Differential effects of melphalan on mouse myeloma (adj. PC-5) and hemopoietic stem cells. Cancer Res. 1971 Dec;31(12):2116–2119. [PubMed] [Google Scholar]
  13. Playfair J. H. Response of mouse T and B lymphocytes to sheep erythrocytes. Nat New Biol. 1972 Jan 26;235(56):115–118. doi: 10.1038/newbio235115a0. [DOI] [PubMed] [Google Scholar]
  14. Rubin A. S., Coons A. H. Specific heterologous enhancement of immune responses. II. Immunological memory cells of thymic origin. J Exp Med. 1972 Feb 1;135(2):437–441. doi: 10.1084/jem.135.2.437. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. SULLIVAN L. W., HERBERT V. SUPPRESSION HEMATOPOIESIS BY ETHANOL. J Clin Invest. 1964 Nov;43:2048–2062. doi: 10.1172/JCI105079. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Tisman G., Herbert V., Go L. T., Brenner L. Inhibition by penicillamine of DNA and protein synthesis by human bone marrow. Proc Soc Exp Biol Med. 1972 Feb;139(2):355–363. doi: 10.3181/00379727-139-36143. [DOI] [PubMed] [Google Scholar]
  17. Tridente G., Biasi G., Chieco-Bianchi L., Fiore-Donati L. Thymus-marrow cell interaction evaluated by PHA stimulation and graft versus host activity. Nature. 1971 Nov 12;234(5324):105–106. doi: 10.1038/234105a0. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES