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. 1973 Dec;52(12):3019–3027. doi: 10.1172/JCI107500

Bone Magnesium Pools in Uremia

Allen C Alfrey 1, Nancy L Miller 1
PMCID: PMC302576  PMID: 4584344

Abstract

Bone magnesium pools were studied in vitro in bone specimens obtained from control subjects, from patients with chronic renal failure before and after renal transplantation, and in a patient with chronic hypomagnesemia. 30% of bone magnesium is in a surface limited pool present either within the hydration shell or else on the crystal surface. The larger fraction of bone magnesium was shown not to be associated with bone matrix but rather to be an integral part of the bone crystal. With incineration this pool was mobilized at the same temperature that sudden enlargement of bone crystal size occurred. It is suggested that heating causes surface calcium to displace magnesium from the apatite crystal. Both magnesium pools are increased in patients with chronic renal failure.

The major factor determining magnesium concentration in bone would appear to be the serum magnesium level. Following renal transplantation, in association with the fall in serum magnesium, surface magnesium was within the normal range; whereas, residual magnesium was not different from the other urenic bones. Both magnesium pools were significantly reduced in a patient with chronic hypomagnesemia. The in vitro studies would suggest that surface magnesium should rapidly reflect changes in serum magnesium levels, whereas, the deeper magnesium pool is probably deposited at time of bone formation with mobilization being dependent upon the resorptive processes. Since magnesium can influence crystal size and stability it seems possible that excess bone magnesium may play a role in renal osteodystrophy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bachra B. N., Trautz O. R., Simon S. L. Precipitation of calcium carbonates and phosphates. 3. The effect of magnesium and fluoride ions on the spontaneous precipitation of calcium carbonates and phosphates. Arch Oral Biol. 1965 Sep-Oct;10(5):731–738. doi: 10.1016/0003-9969(65)90126-3. [DOI] [PubMed] [Google Scholar]
  2. Clark I., Bélanger L. The effects of alterations in dietary magnesium on calcium, phosphate and skeletal metabolism. Calcif Tissue Res. 1967 Dec 20;1(3):204–218. doi: 10.1007/BF02008092. [DOI] [PubMed] [Google Scholar]
  3. Contiguglia S. R., Alfrey A. C., Miller N., Butkus D. Total-body magnesium excess in chronic renal failure. Lancet. 1972 Jun 17;1(7764):1300–1302. doi: 10.1016/s0140-6736(72)91032-x. [DOI] [PubMed] [Google Scholar]
  4. Duckworth J., Godden W. The replenishment of depleted skeletal reserves of magnesium. Biochem J. 1943;37(5):595–598. doi: 10.1042/bj0370595. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FORBES R. M. MINERAL UTILIZATION IN THE RAT. II. RESTORATION OF NORMAL TISSUE LEVELS OF MAGNESIUM AND CALCIUM FOLLOWING MAGNESIUM DEFICIENCY. J Nutr. 1964 May;83:44–48. doi: 10.1093/jn/83.1.44. [DOI] [PubMed] [Google Scholar]
  6. Kaye M., Frueh A. J., Silverman M., Henderson J., Thibault T. A study of vertebral bone powder from patients with chronic renal failure. J Clin Invest. 1970 Mar;49(3):442–453. doi: 10.1172/JCI106253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Martindale L., Heaton F. W. Magnesium deficiency in the adult rat. Biochem J. 1964 Jul;92(1):119–126. doi: 10.1042/bj0920119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Neuman W. F., Mulryan B. J. Synthetic hydroxyapatite crystals. IV. Magnesium incorporation. Calcif Tissue Res. 1971;7(2):133–138. doi: 10.1007/BF02062601. [DOI] [PubMed] [Google Scholar]
  9. Posner A. S. Crystal chemistry of bone mineral. Physiol Rev. 1969 Oct;49(4):760–792. doi: 10.1152/physrev.1969.49.4.760. [DOI] [PubMed] [Google Scholar]
  10. Russell J. E., Avioli L. V. Effect of experimental chronic renal insufficiency on bone mineral and collagen maturation. J Clin Invest. 1972 Dec;51(12):3072–3079. doi: 10.1172/JCI107134. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. SMITH R. H. Calcium and magnesium metabolism in calves. 4. Bone composition in magnesium deficiency and the control of plasma magnesium. Biochem J. 1959 Apr;71(4):609–614. doi: 10.1042/bj0710609. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Walser M. Magnesium metabolism. Ergeb Physiol. 1967;59:185–296. doi: 10.1007/BF02269144. [DOI] [PubMed] [Google Scholar]

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