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. 1993 Jan;61(1):40–47. doi: 10.1128/iai.61.1.40-47.1993

A prospective study of the association between the human humoral immune response to Plasmodium falciparum blood stage antigen gp190 and control of malarial infections.

R Tolle 1, K Früh 1, O Doumbo 1, O Koita 1, M N'Diaye 1, A Fischer 1, K Dietz 1, H Bujard 1
PMCID: PMC302685  PMID: 8418064

Abstract

The human humoral immune response to the Plasmodium falciparum merozoite surface antigen gp190 was analyzed to determine the rate of reinfection by the parasite and the ability to control parasite density. The prospective study was carried out in a West African village where malaria is hyperendemic. No correlation between the antibody titers and protection against infection was observed within the group of children. Positive and negative associations of antibody specificities with protection against and/or control of parasitemia were, however, found for adolescents and adults, respectively. Thus, in adolescents, the presence of antibodies to gp190 fragment M6 correlates with a 50% reduced risk of P. falciparum infection and an increased ability to control parasitemia, whereas in adults, the humoral response to some of the polymorphic regions of gp190 associates with an increased risk of infection.

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Selected References

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  1. Astagneau P., Lepers J. P., Chougnet C., Gaudebout C., Andriamangatiana-Rason M. D., Larouzé B., Deloron P. Assessment of the protective value of antibodies to the Plasmodium falciparum ring-infected erythrocyte surface antigen (RESA): an epidemiologic study in Madagascar. Am J Epidemiol. 1991 Jan 15;133(2):177–184. doi: 10.1093/oxfordjournals.aje.a115856. [DOI] [PubMed] [Google Scholar]
  2. Bouharoun-Tayoun H., Attanath P., Sabchareon A., Chongsuphajaisiddhi T., Druilhe P. Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes. J Exp Med. 1990 Dec 1;172(6):1633–1641. doi: 10.1084/jem.172.6.1633. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Brown G. V., Anders R. F., Mitchell G. F., Heywood P. F. Target antigens of purified human immunoglobulins which inhibit growth of Plasmodium falciparum in vitro. Nature. 1982 Jun 17;297(5867):591–593. doi: 10.1038/297591a0. [DOI] [PubMed] [Google Scholar]
  4. COHEN S., McGREGOR I. A., CARRINGTON S. Gamma-globulin and acquired immunity to human malaria. Nature. 1961 Nov 25;192:733–737. doi: 10.1038/192733a0. [DOI] [PubMed] [Google Scholar]
  5. Certa U., Rotmann D., Matile H., Reber-Liske R. A naturally occurring gene encoding the major surface antigen precursor p190 of Plasmodium falciparum lacks tripeptide repeats. EMBO J. 1987 Dec 20;6(13):4137–4142. doi: 10.1002/j.1460-2075.1987.tb02759.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Chizzolini C., Dupont A., Akue J. P., Kaufmann M. H., Verdini A. S., Pessi A., Del Giudice G. Natural antibodies against three distinct and defined antigens of Plasmodium falciparum in residents of a mesoendemic area in Gabon. Am J Trop Med Hyg. 1988 Aug;39(2):150–156. doi: 10.4269/ajtmh.1988.39.150. [DOI] [PubMed] [Google Scholar]
  7. Etlinger H. M., Caspers P., Matile H., Schoenfeld H. J., Stueber D., Takacs B. Ability of recombinant or native proteins to protect monkeys against heterologous challenge with Plasmodium falciparum. Infect Immun. 1991 Oct;59(10):3498–3503. doi: 10.1128/iai.59.10.3498-3503.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Früh K., Doumbo O., Müller H. M., Koita O., McBride J., Crisanti A., Touré Y., Bujard H. Human antibody response to the major merozoite surface antigen of Plasmodium falciparum is strain specific and short-lived. Infect Immun. 1991 Apr;59(4):1319–1324. doi: 10.1128/iai.59.4.1319-1324.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Früh K., Müller H. M., Bujard H., Crisanti A. A new tool for the serodiagnosis of acute Plasmodium falciparum malaria in individuals with primary infection. J Immunol Methods. 1989 Aug 15;122(1):25–32. doi: 10.1016/0022-1759(89)90330-x. [DOI] [PubMed] [Google Scholar]
  10. Gordon D. M., Davis D. R., Lee M., Lambros C., Harrison B. A., Samuel R., Campbell G. H., Jegathesan M., Selvarajan K., Lewis G. E., Jr Significance of circumsporozoite-specific antibody in the natural transmission of Plasmodium falciparum, Plasmodium vivax, and Plasmodium malariae in an aboriginal (Orang Asli) population of central peninsula Malaysia. Am J Trop Med Hyg. 1991 Jul;45(1):49–56. doi: 10.4269/ajtmh.1991.45.49. [DOI] [PubMed] [Google Scholar]
  11. Hancock K., Tsang V. C. Development and optimization of the FAST-ELISA for detecting antibodies to Schistosoma mansoni. J Immunol Methods. 1986 Sep 27;92(2):167–176. doi: 10.1016/0022-1759(86)90162-6. [DOI] [PubMed] [Google Scholar]
  12. Hoffman S. L., Oster C. N., Plowe C. V., Woollett G. R., Beier J. C., Chulay J. D., Wirtz R. A., Hollingdale M. R., Mugambi M. Naturally acquired antibodies to sporozoites do not prevent malaria: vaccine development implications. Science. 1987 Aug 7;237(4815):639–642. doi: 10.1126/science.3299709. [DOI] [PubMed] [Google Scholar]
  13. Holder A. A., Freeman R. R. Biosynthesis and processing of a Plasmodium falciparum schizont antigen recognized by immune serum and a monoclonal antibody. J Exp Med. 1982 Nov 1;156(5):1528–1538. doi: 10.1084/jem.156.5.1528. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Holder A. A., Freeman R. R. Immunization against blood-stage rodent malaria using purified parasite antigens. Nature. 1981 Nov 26;294(5839):361–364. doi: 10.1038/294361a0. [DOI] [PubMed] [Google Scholar]
  15. Holder A. A., Freeman R. R., Nicholls S. C. Immunization against Plasmodium falciparum with recombinant polypeptides produced in Escherichia coli. Parasite Immunol. 1988 Nov;10(6):607–617. doi: 10.1111/j.1365-3024.1988.tb00248.x. [DOI] [PubMed] [Google Scholar]
  16. Holder A. A., Lockyer M. J., Odink K. G., Sandhu J. S., Riveros-Moreno V., Nicholls S. C., Hillman Y., Davey L. S., Tizard M. L., Schwarz R. T. Primary structure of the precursor to the three major surface antigens of Plasmodium falciparum merozoites. Nature. 1985 Sep 19;317(6034):270–273. doi: 10.1038/317270a0. [DOI] [PubMed] [Google Scholar]
  17. Lew A. M., Langford C. J., Anders R. F., Kemp D. J., Saul A., Fardoulys C., Geysen M., Sheppard M. A protective monoclonal antibody recognizes a linear epitope in the precursor to the major merozoite antigens of Plasmodium chabaudi adami. Proc Natl Acad Sci U S A. 1989 May;86(10):3768–3772. doi: 10.1073/pnas.86.10.3768. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Lyon J. A., Thomas A. W., Hall T., Chulay J. D. Specificities of antibodies that inhibit merozoite dispersal from malaria-infected erythrocytes. Mol Biochem Parasitol. 1989 Aug;36(1):77–85. doi: 10.1016/0166-6851(89)90203-x. [DOI] [PubMed] [Google Scholar]
  19. Majarian W. R., Daly T. M., Weidanz W. P., Long C. A. Passive immunization against murine malaria with an IgG3 monoclonal antibody. J Immunol. 1984 Jun;132(6):3131–3137. [PubMed] [Google Scholar]
  20. Marsh K., Otoo L., Hayes R. J., Carson D. C., Greenwood B. M. Antibodies to blood stage antigens of Plasmodium falciparum in rural Gambians and their relation to protection against infection. Trans R Soc Trop Med Hyg. 1989 May-Jun;83(3):293–303. doi: 10.1016/0035-9203(89)90478-1. [DOI] [PubMed] [Google Scholar]
  21. Müller H. M., Früh K., von Brunn A., Esposito F., Lombardi S., Crisanti A., Bujard H. Development of the human immune response against the major surface protein (gp190) of Plasmodium falciparum. Infect Immun. 1989 Dec;57(12):3765–3769. doi: 10.1128/iai.57.12.3765-3769.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Perrin L. H., Merkli B., Loche M., Chizzolini C., Smart J., Richle R. Antimalarial immunity in Saimiri monkeys. Immunization with surface components of asexual blood stages. J Exp Med. 1984 Aug 1;160(2):441–451. doi: 10.1084/jem.160.2.441. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Peterson M. G., Coppel R. L., Moloney M. B., Kemp D. J. Third form of the precursor to the major merozoite surface antigens of Plasmodium falciparum. Mol Cell Biol. 1988 Jun;8(6):2664–2667. doi: 10.1128/mcb.8.6.2664. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Riley E. M., Allen S. J., Troye-Blomberg M., Bennett S., Perlmann H., Andersson G., Smedman L., Perlmann P., Greenwood B. M. Association between immune recognition of the malaria vaccine candidate antigen Pf155/RESA and resistance to clinical disease: a prospective study in a malaria-endemic region of west Africa. Trans R Soc Trop Med Hyg. 1991 Jul-Aug;85(4):436–443. doi: 10.1016/0035-9203(91)90207-f. [DOI] [PubMed] [Google Scholar]
  25. Rooth I., Perlmann H., Bjorkman A. Plasmodium falciparum reinfection in children from a holoendemic area in relation to seroreactivities against oligopeptides from different malaria antigens. Am J Trop Med Hyg. 1991 Sep;45(3):309–318. doi: 10.4269/ajtmh.1991.45.309. [DOI] [PubMed] [Google Scholar]
  26. Rothman K. J. No adjustments are needed for multiple comparisons. Epidemiology. 1990 Jan;1(1):43–46. [PubMed] [Google Scholar]
  27. Saiki R. K., Gelfand D. H., Stoffel S., Scharf S. J., Higuchi R., Horn G. T., Mullis K. B., Erlich H. A. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science. 1988 Jan 29;239(4839):487–491. doi: 10.1126/science.2448875. [DOI] [PubMed] [Google Scholar]
  28. Sanger F., Nicklen S., Coulson A. R. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463–5467. doi: 10.1073/pnas.74.12.5463. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Siddiqui W. A., Tam L. Q., Kan S. C., Kramer K. J., Case S. E., Palmer K. L., Yamaga K. M., Hui G. S. Induction of protective immunity to monoclonal-antibody-defined Plasmodium falciparum antigens requires strong adjuvant in Aotus monkeys. Infect Immun. 1986 Apr;52(1):314–318. doi: 10.1128/iai.52.1.314-318.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Siddiqui W. A., Tam L. Q., Kramer K. J., Hui G. S., Case S. E., Yamaga K. M., Chang S. P., Chan E. B., Kan S. C. Merozoite surface coat precursor protein completely protects Aotus monkeys against Plasmodium falciparum malaria. Proc Natl Acad Sci U S A. 1987 May;84(9):3014–3018. doi: 10.1073/pnas.84.9.3014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Tanabe K., Mackay M., Goman M., Scaife J. G. Allelic dimorphism in a surface antigen gene of the malaria parasite Plasmodium falciparum. J Mol Biol. 1987 May 20;195(2):273–287. doi: 10.1016/0022-2836(87)90649-8. [DOI] [PubMed] [Google Scholar]
  32. Willcox M., Björkman A., Brohult J., Pehrson P. O., Rombo L., Bengtsson E. A case-control study in northern Liberia of Plasmodium falciparum malaria in haemoglobin S and beta-thalassaemia traits. Ann Trop Med Parasitol. 1983 Jun;77(3):239–246. doi: 10.1080/00034983.1983.11811704. [DOI] [PubMed] [Google Scholar]

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