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. 1994 Oct;62(10):4637–4640. doi: 10.1128/iai.62.10.4637-4640.1994

Protective role of sialophorin (CD43)-expressing cells in experimental Staphylococcus aureus infection.

T Bremell 1, R Holmdahl 1, A Tarkowski 1
PMCID: PMC303155  PMID: 7927732

Abstract

Sialophorin (CD43) is a major surface mucin on most hematopoietic cell lineages, including phagocytes. Defects of CD43 expression occur in Wiskott-Aldrich syndrome, a disease characterized by susceptibility to pyogenic infections. In a newly established rat model of septic Staphylococcus aureus arthritis, we have investigated the role of CD43-expressing cells in the progression of the disease. A single injection of a monoclonal antibody specific for CD43 induced a highly erosive course of arthritis and increased mortality in animals exposed to a suboptimal dose of bacteria. Our results demonstrate that sialophorin-expressing cells play a protective role in the early stage of staphylococcal infection.

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Selected References

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