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. 1987 Mar;84(6):1492–1496. doi: 10.1073/pnas.84.6.1492

Differential regulation of a Thy-1 gene in transgenic mice.

G Kollias, E Spanopoulou, F Grosveld, M Ritter, J Beech, R Morris
PMCID: PMC304460  PMID: 2882505

Abstract

We have generated Thy-1.1-transgenic Thy-1.2 mice to study the developmental expression of the Thy-1 gene in detail by transcriptional and immunological methods. In brain, the expression of the injected gene was identical to that of the endogenous gene in a tissue- and development-specific manner. In lymphoid tissue, the transferred gene was also expressed correctly in the early phases of T-cell lineage development; however, as the T cells matured, the transcription of the transferred gene, but not the endogenous gene, was suppressed. This result shows that different regulatory elements are used to express the Thy-1 gene in early and late lymphoid development.

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These references are in PubMed. This may not be the complete list of references from this article.

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