Skip to main content
PMC home page
Nucleic Acids Research logoLink to Nucleic Acids Research
. 1995 Jun 25;23(12):2342–2343. doi: 10.1093/nar/23.12.2342

Dexamethasone inducible gene expression optimised by glucocorticoid antagonists.

W Mikulits 1, D Chen 1, E W Müllner 1
PMCID: PMC307029  PMID: 7610066

Full text

PDF
2343

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Braselmann S., Graninger P., Busslinger M. A selective transcriptional induction system for mammalian cells based on Gal4-estrogen receptor fusion proteins. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1657–1661. doi: 10.1073/pnas.90.5.1657. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Buetti E., Kühnel B. Distinct sequence elements involved in the glucocorticoid regulation of the mouse mammary tumor virus promoter identified by linker scanning mutagenesis. J Mol Biol. 1986 Aug 5;190(3):379–389. doi: 10.1016/0022-2836(86)90009-4. [DOI] [PubMed] [Google Scholar]
  3. Buetti E. Stably integrated mouse mammary tumor virus long terminal repeat DNA requires the octamer motifs for basal promoter activity. Mol Cell Biol. 1994 Feb;14(2):1191–1203. doi: 10.1128/mcb.14.2.1191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Daniel F., Morello D., Le Bail O., Chambon P., Cayre Y., Kourilsky P. Structure and expression of the mouse beta 2-microglobulin gene isolated from somatic and non-expressing teratocarcinoma cells. EMBO J. 1983;2(7):1061–1065. doi: 10.1002/j.1460-2075.1983.tb01546.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gossen M., Bonin A. L., Bujard H. Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements. Trends Biochem Sci. 1993 Dec;18(12):471–475. doi: 10.1016/0968-0004(93)90009-c. [DOI] [PubMed] [Google Scholar]
  6. Gossen M., Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5547–5551. doi: 10.1073/pnas.89.12.5547. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Helms S. R., Rottman F. M. Characterization of an inducible promoter system to investigate decay of stable mRNA molecules. Nucleic Acids Res. 1990 Jan 25;18(2):255–259. doi: 10.1093/nar/18.2.255. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hengstschläger M., Knöfler M., Müllner E. W., Ogris E., Wintersberger E., Wawra E. Different regulation of thymidine kinase during the cell cycle of normal versus DNA tumor virus-transformed cells. J Biol Chem. 1994 May 13;269(19):13836–13842. [PubMed] [Google Scholar]
  9. Israel D. I., Kaufman R. J. Highly inducible expression from vectors containing multiple GRE's in CHO cells overexpressing the glucocorticoid receptor. Nucleic Acids Res. 1989 Jun 26;17(12):4589–4604. doi: 10.1093/nar/17.12.4589. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Karin M., Haslinger A., Holtgreve H., Richards R. I., Krauter P., Westphal H. M., Beato M. Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene. Nature. 1984 Apr 5;308(5959):513–519. doi: 10.1038/308513a0. [DOI] [PubMed] [Google Scholar]
  11. Kühnel B., Buetti E., Diggelmann H. Functional analysis of the glucocorticoid regulatory elements present in the mouse mammary tumor virus long terminal repeat. A synthetic distal binding site can replace the proximal binding domain. J Mol Biol. 1986 Aug 5;190(3):367–378. doi: 10.1016/0022-2836(86)90008-2. [DOI] [PubMed] [Google Scholar]
  12. Mikulits W., Müllner E. W. Post-transcriptional repression of thymidine kinase expression during cell cycle and growth stimulation. FEBS Lett. 1994 May 30;345(2-3):172–176. doi: 10.1016/0014-5793(94)00451-x. [DOI] [PubMed] [Google Scholar]
  13. Minty A. J., Alonso S., Guénet J. L., Buckingham M. E. Number and organization of actin-related sequences in the mouse genome. J Mol Biol. 1983 Jun 15;167(1):77–101. doi: 10.1016/s0022-2836(83)80035-7. [DOI] [PubMed] [Google Scholar]
  14. Montiel F., Ortiz-Caro J., Villa A., Pascual A., Aranda A. Glucocorticoids regulate insulin binding in a rat glial cell line. Endocrinology. 1987 Jul;121(1):258–265. doi: 10.1210/endo-121-1-258. [DOI] [PubMed] [Google Scholar]
  15. Ogris E., Rotheneder H., Mudrak I., Pichler A., Wintersberger E. A binding site for transcription factor E2F is a target for trans activation of murine thymidine kinase by polyomavirus large T antigen and plays an important role in growth regulation of the gene. J Virol. 1993 Apr;67(4):1765–1771. doi: 10.1128/jvi.67.4.1765-1771.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Raaka B. M., Finnerty M., Samuels H. H. The glucocorticoid antagonist 17 alpha-methyltestosterone binds to the 10 S glucocorticoid receptor and blocks agonist-mediated dissociation of the 10 S oligomer to the 4 S deoxyribonucleic acid-binding subunit. Mol Endocrinol. 1989 Feb;3(2):332–341. doi: 10.1210/mend-3-2-332. [DOI] [PubMed] [Google Scholar]
  17. Samuels H. H., Stanley F., Shapiro L. E. Control of growth hormone synthesis in cultured GH1 cells by 3,5,3'-triiodo-L-thyronine and glucocorticoid agonists and antagonists: studies on the independent and synergistic regulation of the growth hormone response. Biochemistry. 1979 Feb 20;18(4):715–721. doi: 10.1021/bi00571a025. [DOI] [PubMed] [Google Scholar]
  18. Schüle R., Muller M., Otsuka-Murakami H., Renkawitz R. Cooperativity of the glucocorticoid receptor and the CACCC-box binding factor. Nature. 1988 Mar 3;332(6159):87–90. doi: 10.1038/332087a0. [DOI] [PubMed] [Google Scholar]
  19. Seiler-Tuyns A., Birnstiel M. L. Structure and expression in L-cells of a cloned H4 histone gene of the mouse. J Mol Biol. 1981 Oct 5;151(4):607–625. doi: 10.1016/0022-2836(81)90426-5. [DOI] [PubMed] [Google Scholar]
  20. Seiser C., Knöfler M., Rudelstorfer I., Haas R., Wintersberger E. Mouse thymidine kinase: the promoter sequence and the gene and pseudogene structures in normal cells and in thymidine kinase deficient mutants. Nucleic Acids Res. 1989 Jan 11;17(1):185–195. doi: 10.1093/nar/17.1.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Wiedemann L. M., Johnson L. F. Regulation of dihydrofolate reductase synthesis in an overproducing 3T6 cell line during transition from resting to growing state. Proc Natl Acad Sci U S A. 1979 Jun;76(6):2818–2822. doi: 10.1073/pnas.76.6.2818. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Yarranton G. T. Inducible vectors for expression in mammalian cells. Curr Opin Biotechnol. 1992 Oct;3(5):506–511. doi: 10.1016/0958-1669(92)90078-w. [DOI] [PubMed] [Google Scholar]

Articles from Nucleic Acids Research are provided here courtesy of Oxford University Press

RESOURCES