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. 1994 Jun 11;22(11):2036–2041. doi: 10.1093/nar/22.11.2036

A novel growth-inducible gene that encodes a protein with a conserved cold-shock domain.

K Ito 1, K Tsutsumi 1, T Kuzumaki 1, P F Gomez 1, K Otsu 1, K Ishikawa 1
PMCID: PMC308118  PMID: 8029009

Abstract

We have isolated a cDNA that encodes a novel member of the Y-box binding protein family, termed as RYB-a (Rat Y-box Binding protein-a). RYB-a is a 31 kDa protein that contains a conserved cold-shock domain and an amino acid alignment similar to those of charge zipper proteins. Expression of RYB-a mRNA was highly abundant in the skeletal muscle, spleen, and fetal liver. The expression is very low in new-born and adult livers, suggesting its expression is under developmental regulation. In addition, the expression of RYB-a mRNA was induced in the liver during regeneration and by stimulation of quiescent fibroblast cells with serum. Induction in the fibroblasts was inhibited by treating the cell with a specific tyrosine kinase inhibitor, genistein or by detachment of cell-adhesion. Since both treatments are known to inhibit G1 cells to enter S phase, RYB-a gene is thought to be a member of growth-inducible genes.

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