Skip to main content
Nucleic Acids Research logoLink to Nucleic Acids Research
. 1993 May 11;21(9):2139–2142. doi: 10.1093/nar/21.9.2139

Timing of replication of beta satellite repeats of human chromosomes.

K G Ten Hagen 1, S N Cohen 1
PMCID: PMC309476  PMID: 8502554

Abstract

The beta satellite sequences of the human genome are a family of genetic elements consisting of 68-69 bp monomeric units repeated contiguously in long arrays up to 1 Mb in length. We have determined the timing of replication of beta satellite subgroups located in the heterochromatic portion of chromosome 9 and on the acrocentric chromosomes in regions both distal and proximal to the rDNA genes. We report that these dispersed subgroups of beta satellite sequences all replicate late during S phase of the cell cycle.

Full text

PDF
2141

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adegoke J. A., Taylor J. H. Sequence programming of DNA replication over the S phase of Chinese hamster cells. Exp Cell Res. 1977 Jan;104(1):47–54. doi: 10.1016/0014-4827(77)90067-2. [DOI] [PubMed] [Google Scholar]
  2. Braunstein J. D., Schildkraut C. L. The beta-major and beta-minor globin genes in murine erythroleukemia cells replicate during the same early interval of the S phase. Biochem Biophys Res Commun. 1984 Aug 30;123(1):108–113. doi: 10.1016/0006-291x(84)90386-3. [DOI] [PubMed] [Google Scholar]
  3. Brown E. H., Iqbal M. A., Stuart S., Hatton K. S., Valinsky J., Schildkraut C. L. Rate of replication of the murine immunoglobulin heavy-chain locus: evidence that the region is part of a single replicon. Mol Cell Biol. 1987 Jan;7(1):450–457. doi: 10.1128/mcb.7.1.450. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Calza R. E., Eckhardt L. A., DelGiudice T., Schildkraut C. L. Changes in gene position are accompanied by a change in time of replication. Cell. 1984 Mar;36(3):689–696. doi: 10.1016/0092-8674(84)90349-0. [DOI] [PubMed] [Google Scholar]
  5. Crossen P. E., Pathak S., Arrighi F. E. A high resolution study of the DNA replication patterns of chinese hamster chromosomes using sister chromatid differential staining technique. Chromosoma. 1975 Nov 11;52(4):339–347. doi: 10.1007/BF00364018. [DOI] [PubMed] [Google Scholar]
  6. Dhar V., Mager D., Iqbal A., Schildkraut C. L. The coordinate replication of the human beta-globin gene domain reflects its transcriptional activity and nuclease hypersensitivity. Mol Cell Biol. 1988 Nov;8(11):4958–4965. doi: 10.1128/mcb.8.11.4958. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Edenberg H. J., Huberman J. A. Eukaryotic chromosome replication. Annu Rev Genet. 1975;9:245–284. doi: 10.1146/annurev.ge.09.120175.001333. [DOI] [PubMed] [Google Scholar]
  8. Epner E., Forrester W. C., Groudine M. Asynchronous DNA replication within the human beta-globin gene locus. Proc Natl Acad Sci U S A. 1988 Nov;85(21):8081–8085. doi: 10.1073/pnas.85.21.8081. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Feinberg A. P., Vogelstein B. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. Anal Biochem. 1984 Feb;137(1):266–267. doi: 10.1016/0003-2697(84)90381-6. [DOI] [PubMed] [Google Scholar]
  10. Furst A., Brown E. H., Braunstein J. D., Schildkraut C. L. alpha-Globulin sequences are located in a region of early-replicating DNA in murine erythroleukemia cells. Proc Natl Acad Sci U S A. 1981 Feb;78(2):1023–1027. doi: 10.1073/pnas.78.2.1023. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gilbert D. M., Cohen S. N. Bovine papilloma virus plasmids replicate randomly in mouse fibroblasts throughout S phase of the cell cycle. Cell. 1987 Jul 3;50(1):59–68. doi: 10.1016/0092-8674(87)90662-3. [DOI] [PubMed] [Google Scholar]
  12. Goldman M. A., Holmquist G. P., Gray M. C., Caston L. A., Nag A. Replication timing of genes and middle repetitive sequences. Science. 1984 May 18;224(4650):686–692. doi: 10.1126/science.6719109. [DOI] [PubMed] [Google Scholar]
  13. Greig G. M., Willard H. F. Beta satellite DNA: characterization and localization of two subfamilies from the distal and proximal short arms of the human acrocentric chromosomes. Genomics. 1992 Mar;12(3):573–580. doi: 10.1016/0888-7543(92)90450-7. [DOI] [PubMed] [Google Scholar]
  14. Hand R. Eucaryotic DNA: organization of the genome for replication. Cell. 1978 Oct;15(2):317–325. doi: 10.1016/0092-8674(78)90001-6. [DOI] [PubMed] [Google Scholar]
  15. Hatton K. S., Dhar V., Brown E. H., Iqbal M. A., Stuart S., Didamo V. T., Schildkraut C. L. Replication program of active and inactive multigene families in mammalian cells. Mol Cell Biol. 1988 May;8(5):2149–2158. doi: 10.1128/mcb.8.5.2149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Hatton K. S., Schildkraut C. L. The mouse immunoglobulin kappa light-chain genes are located in early- and late-replicating regions of chromosome 6. Mol Cell Biol. 1990 Aug;10(8):4314–4323. doi: 10.1128/mcb.10.8.4314. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Iqbal M. A., Chinsky J., Didamo V., Schildkraut C. L. Replication of proto-oncogenes early during the S phase in mammalian cell lines. Nucleic Acids Res. 1987 Jan 12;15(1):87–103. doi: 10.1093/nar/15.1.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Laskey R. A., Harland R. M. Replication origins in the eucaryotic chromosome. Cell. 1981 May;24(2):283–284. doi: 10.1016/0092-8674(81)90316-0. [DOI] [PubMed] [Google Scholar]
  19. Mueller G. C., Kajiwara K. Early- and late-replicating deoxyribonucleic acid complexes in HeLa nuclei. Biochim Biophys Acta. 1966 Jan 18;114(1):108–115. doi: 10.1016/0005-2787(66)90258-9. [DOI] [PubMed] [Google Scholar]
  20. Schmidt M., Migeon B. R. Asynchronous replication of homologous loci on human active and inactive X chromosomes. Proc Natl Acad Sci U S A. 1990 May;87(10):3685–3689. doi: 10.1073/pnas.87.10.3685. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Selig S., Ariel M., Goitein R., Marcus M., Cedar H. Regulation of mouse satellite DNA replication time. EMBO J. 1988 Feb;7(2):419–426. doi: 10.1002/j.1460-2075.1988.tb02829.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Stubblefield E. Analysis of the replication pattern of Chinese hamster chromosomes using 5-bromodeoxyuridine suppression of 33258 Hoechst fluorescence. Chromosoma. 1975 Dec 10;53(3):209–221. doi: 10.1007/BF00329172. [DOI] [PubMed] [Google Scholar]
  23. TAYLOR J. H. Asynchronous duplication of chromosomes in cultured cells of Chinese hamster. J Biophys Biochem Cytol. 1960 Jun;7:455–464. doi: 10.1083/jcb.7.3.455. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Ten Hagen K. G., Gilbert D. M., Willard H. F., Cohen S. N. Replication timing of DNA sequences associated with human centromeres and telomeres. Mol Cell Biol. 1990 Dec;10(12):6348–6355. doi: 10.1128/mcb.10.12.6348. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Waye J. S., Willard H. F. Human beta satellite DNA: genomic organization and sequence definition of a class of highly repetitive tandem DNA. Proc Natl Acad Sci U S A. 1989 Aug;86(16):6250–6254. doi: 10.1073/pnas.86.16.6250. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Nucleic Acids Research are provided here courtesy of Oxford University Press

RESOURCES